1X81

Farnesyl transferase structure of Jansen compound

Summary for 1X81

• Entry DOI: 10.2210/pdb1x81/pdb
• Related: 1NI1
• Descriptor: Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (4 entities in total)
• Functional Keywords: fanesyltransferase, transferase
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 2
• Total formula weight: 83062.40

Authors

Li, Q.,Claiborne, A.,Li, T.,Hasvold, L.,Stoll, V.S.,Muchmore, S.,Jakob, C.G.,Gu, W.,Cohen, J.,Hutchins, C.,Frost, D.,Rosenberg, S.H.,Sham, H.L. (deposition date: 2004-08-16, release date: 2004-12-21, Last modification date: 2024-02-14)

Primary citation

Li, Q.,Claiborne, A.,Li, T.,Hasvold, L.,Stoll, V.S.,Muchmore, S.,Jakob, C.G.,Gu, W.,Cohen, J.,Hutchins, C.,Frost, D.,Rosenberg, S.H.,Sham, H.L.
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Bioorg.Med.Chem.Lett., 14:5367-5370, 2004

PubMed Abstract: As a part of our efforts to identify potent inhibitors of farnesyltransferase (FTase), modification of the structure of tipifarnib through structure-based design was undertaken by replacing the 2-quinolones with 4-quinolones and pyridones, and subsequent relocation of the D-ring to the N-methyl group on the imidazole ring. This study has yielded a novel series of potent and selective FTase inhibitors. The X-ray structure of tipifarnib (1) in complex with FTase was described.

PubMed: 15454228
DOI: 10.1016/j.bmcl.2004.08.012

Experimental method

X-RAY DIFFRACTION (3.5 Å)