4PUF

Complex between the Salmonella T3SS effector SlrP and its human target thioredoxin-1

Summary for 4PUF

DescriptorE3 ubiquitin-protein ligase SlrP, Thioredoxin (2 entities in total)
Functional Keywordslrr domain, nel domain, e3 ubiquitin ligase, human thioredoxin 1, ligase -oxidoreductase complex, ligase-oxidoreductase complex, ligase/oxidoreductase
Biological sourceSalmonella enterica subsp. enterica serovar Typhimurium
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Cellular locationSecreted D0ZRB2
Nucleus P10599
Total number of polymer chains4
Total molecular weight172247.14
Authors
Zouhir, S.,Bernal-Bayard, J.,Cordero-Alba, M.,Cardenal-Munoz, E.,Guimaraes, B.,Lazar, N.,Ramos-Morales, F.,Nessler, S. (deposition date: 2014-03-13, release date: 2014-09-17, Last modification date: 2014-11-05)
Primary citation
Zouhir, S.,Bernal-Bayard, J.,Cordero-Alba, M.,Cardenal-Munoz, E.,Guimaraes, B.,Lazar, N.,Ramos-Morales, F.,Nessler, S.
The structure of the Slrp-Trx1 complex sheds light on the autoinhibition mechanism of the type III secretion system effectors of the NEL family.
Biochem.J., 464:135-144, 2014
PubMed: 25184225 (PDB entries with the same primary citation)
DOI: 10.1042/BJ20140587
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.296 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.30610 0.9% 0.8% 4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25