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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4PUF

Complex between the Salmonella T3SS effector SlrP and its human target thioredoxin-1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004842molecular_functionubiquitin-protein transferase activity
A0016567biological_processprotein ubiquitination
B0004842molecular_functionubiquitin-protein transferase activity
B0016567biological_processprotein ubiquitination
C0003723molecular_functionRNA binding
C0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0009314biological_processresponse to radiation
C0015035molecular_functionprotein-disulfide reductase activity
C0019725biological_processcellular homeostasis
C0042803molecular_functionprotein homodimerization activity
C0043388biological_processpositive regulation of DNA binding
C0045454biological_processcell redox homeostasis
C0047134molecular_functionprotein-disulfide reductase [NAD(P)H] activity
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0055114biological_processobsolete oxidation-reduction process
C0061692biological_processcellular detoxification of hydrogen peroxide
C0070062cellular_componentextracellular exosome
C0071731biological_processresponse to nitric oxide
D0003723molecular_functionRNA binding
D0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0009314biological_processresponse to radiation
D0015035molecular_functionprotein-disulfide reductase activity
D0019725biological_processcellular homeostasis
D0042803molecular_functionprotein homodimerization activity
D0043388biological_processpositive regulation of DNA binding
D0045454biological_processcell redox homeostasis
D0047134molecular_functionprotein-disulfide reductase [NAD(P)H] activity
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0055114biological_processobsolete oxidation-reduction process
D0061692biological_processcellular detoxification of hydrogen peroxide
D0070062cellular_componentextracellular exosome
D0071731biological_processresponse to nitric oxide
Functional Information from PROSITE/UniProt
site_idPS00194
Number of Residues19
DetailsTHIOREDOXIN_1 Thioredoxin family active site. VVdFSatWCGPCKmIkpfF
ChainResidueDetails
CVAL24-PHE42
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues38
DetailsRepeat: {"description":"LRR 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues42
DetailsRepeat: {"description":"LRR 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues38
DetailsRepeat: {"description":"LRR 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues42
DetailsRepeat: {"description":"LRR 4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues40
DetailsRepeat: {"description":"LRR 5"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues38
DetailsRepeat: {"description":"LRR 6"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues40
DetailsRepeat: {"description":"LRR 7"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues42
DetailsRepeat: {"description":"LRR 8"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues40
DetailsRepeat: {"description":"LRR 9"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues40
DetailsRepeat: {"description":"LRR 10"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues14
DetailsRegion: {"description":"Linker","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsActive site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01398","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues206
DetailsDomain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9108029","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsSite: {"description":"Deprotonates C-terminal active site Cys","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsSite: {"description":"Contributes to redox potential value","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P10639","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues4
DetailsModified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"17260951","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsModified residue: {"description":"S-nitrosocysteine; alternate","evidences":[{"source":"PubMed","id":"16408020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17606900","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10639","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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