4P5Q
Human EphA3 Kinase domain in complex with quinoxaline derivatives
Summary for 4P5Q
| Entry DOI | 10.2210/pdb4p5q/pdb |
| Descriptor | Ephrin type-A receptor 3, 2-amino-1-(2-chlorophenyl)-N-(3-ethoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide (3 entities in total) |
| Functional Keywords | transferase, transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P29320 |
| Total number of polymer chains | 1 |
| Total formula weight | 40882.07 |
| Authors | Dong, J.,Caflisch, A. (deposition date: 2014-03-19, release date: 2014-08-13, Last modification date: 2023-12-20) |
| Primary citation | Unzue, A.,Dong, J.,Lafleur, K.,Zhao, H.,Frugier, E.,Caflisch, A.,Nevado, C. Pyrrolo[3,2-b]quinoxaline Derivatives as Types I1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and in Vivo Validation. J.Med.Chem., 57:6834-, 2014 Cited by PubMed: 25076195DOI: 10.1021/jm5009242 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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