2VPH
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![BU of 2vph by Molmil](/molmil-images/mine/2vph) | Crystal structure of the human protein tyrosine phosphatase, non- receptor type 4, PDZ domain | 分子名称: | TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 4 | 著者 | Roos, A.K, Wang, J, Burgess-Brown, N, Elkins, J.M, Kavanagh, K, Pike, A.C.W, Filippakopoulos, P, Arrowsmith, C.H, Weigelt, J, Edwards, A, von Delft, F, Bountra, C, Knapp, S. | 登録日 | 2008-02-29 | 公開日 | 2008-03-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structure of the Human Protein Tyrosine Phosphatase, Non-Receptor Type 4, Pdz Domain To be Published
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4RK6
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![BU of 4rk6 by Molmil](/molmil-images/mine/4rk6) | Crystal structure of LacI family transcriptional regulator CCPA from Weissella paramesenteroides, Target EFI-512926, with bound glucose | 分子名称: | Glucose-resistance amylase regulator, alpha-D-glucopyranose | 著者 | Patskovsky, Y, Toro, R, Bhosle, R, Al Obaidi, N, Chamala, S, Attonito, J.D, Scott Glenn, A, Chowdhury, S, Lafleur, J, Siedel, R.D, Hillerich, B, Love, J, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2014-10-11 | 公開日 | 2014-10-29 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Crystal structure of transcriptional regulator CCPA from Weissella paramesenteroides, Target EFI-512926 To be Published
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7LQW
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![BU of 7lqw by Molmil](/molmil-images/mine/7lqw) | Cryo-EM structure of NTD-directed neutralizing antibody 2-17 Fab in complex with SARS-CoV-2 S2P spike | 分子名称: | 2-17 Heavy Chain, 2-17 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L. | 登録日 | 2021-02-15 | 公開日 | 2021-03-24 | 最終更新日 | 2021-05-26 | 実験手法 | ELECTRON MICROSCOPY (4.47 Å) | 主引用文献 | Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite. Cell Host Microbe, 29, 2021
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1AYD
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4RK4
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![BU of 4rk4 by Molmil](/molmil-images/mine/4rk4) | Crystal structure of LacI family transcriptional regulator from Lactobacillus casei, Target EFI-512911, with bound glucose | 分子名称: | SODIUM ION, Transcriptional regulator, LacI family, ... | 著者 | Patskovsky, Y, Toro, R, Bhosle, R, Al Obaidi, N, Chamala, S, Attonito, J.D, Scott Glenn, A, Chowdhury, S, Lafleur, J, Siedel, R.D, Hillerich, B, Love, J, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2014-10-11 | 公開日 | 2014-11-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Crystal Structure of LacI Transcriptional Regulator Lsei_2103 from Lactobacillus casei, Target EFI-512911 To be Published
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4AKT
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![BU of 4akt by Molmil](/molmil-images/mine/4akt) | PatG macrocyclase in complex with peptide | 分子名称: | SUBSTRATE ANALOGUE, THIAZOLINE OXIDASE/SUBTILISIN-LIKE PROTEASE | 著者 | Koehnke, J, Bent, A, Houssen, W.E, Zollman, D, Morawitz, F, Shirran, S, Vendome, J, Nneoyiegbe, A.F, Trembleau, L, Botting, C.H, Smith, M.C.M, Jaspars, M, Naismith, J.H. | 登録日 | 2012-02-28 | 公開日 | 2012-07-18 | 最終更新日 | 2013-11-06 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | The Mechanism of Patellamide Macrocyclization Revealed by the Characterization of the Patg Macrocyclase Domain. Nat.Struct.Mol.Biol., 19, 2012
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4A8D
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![BU of 4a8d by Molmil](/molmil-images/mine/4a8d) | DegP dodecamer with bound OMP | 分子名称: | OUTER MEMBRANE PROTEIN C, PERIPLASMIC SERINE ENDOPROTEASE DEGP | 著者 | Malet, H, Krojer, T, Sawa, J, Schafer, E, Saibil, H.R, Ehrmann, M, Clausen, T. | 登録日 | 2011-11-20 | 公開日 | 2012-01-11 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (28 Å) | 主引用文献 | Newly Folded Substrates Inside the Molecular Cage of the Htra Chaperone Degq Nat.Struct.Mol.Biol., 19, 2012
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2ZKM
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![BU of 2zkm by Molmil](/molmil-images/mine/2zkm) | Crystal Structure of Phospholipase C Beta 2 | 分子名称: | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2, CALCIUM ION | 著者 | Hicks, S.N, Jezyk, M.R, Gershberg, S, Seifert, J.P, Harden, T.K, Sondek, J. | 登録日 | 2008-03-26 | 公開日 | 2008-08-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | General and versatile autoinhibition of PLC isozymes Mol.Cell, 31, 2008
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5CQ2
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![BU of 5cq2 by Molmil](/molmil-images/mine/5cq2) | Crystal Structure of tandem WW domains of ITCH in complex with TXNIP peptide | 分子名称: | E3 ubiquitin-protein ligase Itchy homolog, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION | 著者 | Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2015-07-21 | 公開日 | 2015-09-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem.J., 473, 2016
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4HGY
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![BU of 4hgy by Molmil](/molmil-images/mine/4hgy) | Structure of the CcbJ Methyltransferase from Streptomyces caelestis | 分子名称: | 1,2-ETHANEDIOL, CcbJ, SULFATE ION | 著者 | Bauer, J.A, Ondrovicova, G, Kutejova, E, Janata, J. | 登録日 | 2012-10-09 | 公開日 | 2013-10-30 | 最終更新日 | 2014-04-16 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure and possible mechanism of the CcbJ methyltransferase from Streptomyces caelestis. Acta Crystallogr.,Sect.D, 70, 2014
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4S3B
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![BU of 4s3b by Molmil](/molmil-images/mine/4s3b) | IspG in complex with Intermediate II | 分子名称: | (3S)-1,3-dihydroxy-4-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}-2-methylbut-2-ylium, carbokation intermediate, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, ... | 著者 | Quitterer, F, Frank, A, Wang, K, Rao, G, O'Dowd, B, Li, J, Guerra, F, Abdel-Azeim, S, Bacher, A, Eppinger, J, Oldfield, E, Groll, M. | 登録日 | 2015-01-26 | 公開日 | 2015-04-29 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE). J.Mol.Biol., 427, 2015
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4MD5
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![BU of 4md5 by Molmil](/molmil-images/mine/4md5) | Immune Receptor | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Scally, S.W, Rossjohn, J. | 登録日 | 2013-08-22 | 公開日 | 2013-12-04 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. J.Exp.Med., 210, 2013
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2ZNO
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![BU of 2zno by Molmil](/molmil-images/mine/2zno) | Human PPAR gamma ligand binding domain in complex with a synthetic agonist TIPP703 | 分子名称: | (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid, Peroxisome proliferator-activated receptor gamma | 著者 | Oyama, T, Waku, T, Kasuga, J, Miyachi, H, Morikawa, K. | 登録日 | 2008-04-30 | 公開日 | 2009-05-05 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures Acta Crystallogr.,Sect.D, 65, 2009
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6I7E
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![BU of 6i7e by Molmil](/molmil-images/mine/6i7e) | Plasmodium falciparum Myosin A, Pre-powerstroke | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin-A, ... | 著者 | Robert-Paganin, J, Auguin, D, Moussaoui, D, Jousset, G, Baum, J, Trybus, K.M, Houdusse, A. | 登録日 | 2018-11-16 | 公開日 | 2019-08-07 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.492 Å) | 主引用文献 | Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism. Nat Commun, 10, 2019
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3KYN
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![BU of 3kyn by Molmil](/molmil-images/mine/3kyn) | Crystal structure of HLA-G presenting KGPPAALTL peptide | 分子名称: | Beta-2-microglobulin, CHLORIDE ION, COBALT (II) ION, ... | 著者 | Walpole, N.G, Rossjohn, J, Clements, C.S. | 登録日 | 2009-12-06 | 公開日 | 2010-02-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The structure and stability of the monomorphic HLA-G are influenced by the nature of the bound peptide J.Mol.Biol., 397, 2010
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2X18
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![BU of 2x18 by Molmil](/molmil-images/mine/2x18) | The crystal structure of the PH domain of human AKT3 protein kinase | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE | 著者 | Vollmar, M, Wang, J, Zhang, Y, Elkins, J.M, Burgess-Brown, N, Chaikuad, A, Pike, A.C.W, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S. | 登録日 | 2009-12-22 | 公開日 | 2010-03-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | The Crystal Structure of the Ph Domain of Human Akt3 Protein Kinase To be Published
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1UWB
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![BU of 1uwb by Molmil](/molmil-images/mine/1uwb) | TYR 181 CYS HIV-1 RT/8-CL TIBO | 分子名称: | 5-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE, REVERSE TRANSCRIPTASE | 著者 | Das, K, Ding, J, Hsiou, Y, Arnold, E. | 登録日 | 1996-11-21 | 公開日 | 1997-05-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. J.Mol.Biol., 264, 1996
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5FKQ
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![BU of 5fkq by Molmil](/molmil-images/mine/5fkq) | Unraveling the first step of xyloglucan degradation by the soil saprophyte Cellvibrio japonicus through the functional and structural characterization of a potent GH74 endo-xyloglucanase | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, ENDO-1,4-BETA-GLUCANASE/XYLOGLUCANASE, ... | 著者 | Attia, M, Stepper, J, Davies, G.J, Brumer, H. | 登録日 | 2015-10-19 | 公開日 | 2015-11-04 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Functional and Structural Characterization of a Potent Gh74 Endo-Xyloglucanase from the Soil Saprophyte Cellvibrio Japonicus Unravels the First Step of Xyloglucan Degradation. FEBS J., 283, 2016
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3DEI
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![BU of 3dei by Molmil](/molmil-images/mine/3dei) | Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors | 分子名称: | (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3 | 著者 | Wu, J, Du, J, Li, J, Ding, J. | 登録日 | 2008-06-10 | 公開日 | 2008-09-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
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2X7F
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![BU of 2x7f by Molmil](/molmil-images/mine/2x7f) | Crystal structure of the kinase domain of human Traf2- and Nck- interacting Kinase with Wee1Chk1 inhibitor | 分子名称: | 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, SODIUM ION, TRAF2 AND NCK-INTERACTING PROTEIN KINASE | 著者 | Vollmar, M, Alfano, I, Shrestha, B, Bray, J, Muniz, J.R.C, Roos, A, Filippakopoulos, P, Burgess-Brown, N, Ugochukwu, E, Gileadi, O, Phillips, C, Mahajan, P, Pike, A.C.W, Fedorov, O, Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S. | 登録日 | 2010-02-26 | 公開日 | 2010-07-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of the Kinase Domain of Human Traf2- and Nck-Interacting Kinase with Wee1Chk1 Inhibitor To be Published
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6IF8
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![BU of 6if8 by Molmil](/molmil-images/mine/6if8) | Aeromonas hydrophila MtaN-2 complexed with adenine | 分子名称: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE | 著者 | Chen, J, Liu, W, Wang, L, Shang, F, Lan, J, Chen, Y, Xu, Y. | 登録日 | 2018-09-18 | 公開日 | 2018-10-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Aeromonas hydrophila MtaN-2 complexed with adenine To Be Published
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4RJZ
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![BU of 4rjz by Molmil](/molmil-images/mine/4rjz) | Crystal structure of ATU4361 sugar transporter from Agrobacterium fabrum C58, target EFI-510558, an open conformation | 分子名称: | ABC transporter, substrate binding protein (Sugar), CHLORIDE ION, ... | 著者 | Patskovsky, Y, Toro, R, Bhosle, R, Al Obaidi, N, Chamala, S, Attonito, J.D, Scott Glenn, A, Chowdhury, S, Lafleur, J, Siedel, R.D, Hillerich, B, Love, J, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2014-10-11 | 公開日 | 2014-11-05 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | 主引用文献 | Crystal Structure of Maltoside Transporter ATU4361 from Agrobacterium Fabrum, Target EFI-510558 To be Published
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5G02
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![BU of 5g02 by Molmil](/molmil-images/mine/5g02) | Crystal Structure of zebrafish Protein Arginine Methyltransferase 2 with SFG | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LITHIUM ION, ... | 著者 | Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J. | 登録日 | 2016-03-16 | 公開日 | 2016-11-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.451 Å) | 主引用文献 | Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors. FEBS J., 284, 2017
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7KXK
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4RPF
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![BU of 4rpf by Molmil](/molmil-images/mine/4rpf) | Crystal structure of homoserine kinase from Yersinia pestis Nepal516, NYSGRC target 032715 | 分子名称: | CITRIC ACID, Homoserine kinase | 著者 | Ptskovsky, Y, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2014-10-30 | 公開日 | 2014-11-12 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of Homoserine Kinase from Yersinia Pestis Nepal516, Nysgrc Target 032715 To be Published
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