Human PPAR gamma ligand binding domain in complex with a synthetic agonist TIPP703

Summary for 2ZNO

Related2ZNN 2ZNP 2ZNQ
DescriptorPeroxisome proliferator-activated receptor gamma, (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid (3 entities in total)
Functional Keywordsnuclear receptor, protein-ligand complex, ppar, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight66068.65
Oyama, T.,Waku, T.,Kasuga, J.,Miyachi, H.,Morikawa, K. (deposition date: 2008-04-30, release date: 2009-05-05, Last modification date: 2016-03-02)
Primary citation
Oyama, T.,Toyota, K.,Waku, T.,Hirakawa, Y.,Nagasawa, N.,Kasuga, J.,Hashimoto, Y.,Miyachi, H.,Morikawa, K.
Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures
Acta Crystallogr.,Sect.D, 65:786-795, 2009
PubMed: 19622862 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444909015935
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.284253.4%6.6%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report