2ZNQ

Human PPAR delta ligand binding domain in complex with a synthetic agonist TIPP401

Summary for 2ZNQ

Related2ZNN 2ZNO 2ZNP
DescriptorPeroxisome proliferator-activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid, ... (4 entities in total)
Functional Keywordsnuclear receptor, protein-ligand complex, ppar, activator, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q03181
Total number of polymer chains2
Total molecular weight64466.76
Authors
Oyama, T.,Hirakawa, Y.,Nagasawa, N.,Miyachi, H.,Morikawa, K. (deposition date: 2008-04-30, release date: 2009-05-05, Last modification date: 2016-03-02)
Primary citation
Oyama, T.,Toyota, K.,Waku, T.,Hirakawa, Y.,Nagasawa, N.,Kasuga, J.,Hashimoto, Y.,Miyachi, H.,Morikawa, K.
Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures
Acta Crystallogr.,Sect.D, 65:786-795, 2009
PubMed: 19622862 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444909015935
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.65 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.269101.2%6.9%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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