5D9Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5d9y by Molmil](/molmil-images/mine/5d9y) | Crystal structure of TET2-5fC complex | 分子名称: | DNA (5'-D(*AP*CP*TP*GP*TP*(5FC)P*GP*AP*AP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*TP*TP*CP*GP*AP*CP*AP*GP*T)-3'), FE (III) ION, ... | 著者 | Hu, L, Cheng, J, Rao, Q, Li, Z, Li, J, Xu, Y. | 登録日 | 2015-08-19 | 公開日 | 2015-11-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.971 Å) | 主引用文献 | Structural insight into substrate preference for TET-mediated oxidation. Nature, 527, 2015
|
|
7LHZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lhz by Molmil](/molmil-images/mine/7lhz) | K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and (3S)-10-[(3R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-9-fluoro-3-methyl-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid (compound 25) | 分子名称: | (3S)-10-[(3R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-9-fluoro-3-methyl-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*GP*AP*TP*CP*AP*TP*AP*CP*AP*AP*CP*GP*TP*AP*A)-3'), ... | 著者 | Noeske, J, Shu, W, Bellamacina, C. | 登録日 | 2021-01-26 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria. J.Med.Chem., 64, 2021
|
|
4PXQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pxq by Molmil](/molmil-images/mine/4pxq) | Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide | 分子名称: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, D-glucuronyl C5 epimerase B | 著者 | Ke, J, Qin, Y, Gu, X, Tan, J, Brunzelle, J.S, Xu, H.E, Ding, K. | 登録日 | 2014-03-24 | 公開日 | 2015-01-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and Functional Study of d-Glucuronyl C5-epimerase. J.Biol.Chem., 290, 2015
|
|
2F76
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f76 by Molmil](/molmil-images/mine/2f76) | Solution structure of the M-PMV wild type matrix protein (p10) | 分子名称: | Core protein p10 | 著者 | Vlach, J, Lipov, J, Veverka, V, Lang, J, Srb, P, Rumlova, M, Hunter, E, Ruml, T, Hrabal, R. | 登録日 | 2005-11-30 | 公開日 | 2006-12-05 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein. Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
2EW7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ew7 by Molmil](/molmil-images/mine/2ew7) | Crystal Structure of Helicobacter Pylori peptide deformylase | 分子名称: | COBALT (II) ION, peptide deformylase | 著者 | Cai, J. | 登録日 | 2005-11-02 | 公開日 | 2006-10-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation Protein Sci., 15, 2006
|
|
5DEU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5deu by Molmil](/molmil-images/mine/5deu) | Crystal structure of TET2-5hmC complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, DNA (5'-D(*AP*CP*CP*AP*CP*(5HC)P*GP*GP*TP*GP*GP*T)-3'), ... | 著者 | Hu, L, Cheng, J, Rao, Q, Li, Z, Li, J, Xu, Y. | 登録日 | 2015-08-26 | 公開日 | 2015-11-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Structural insight into substrate preference for TET-mediated oxidation. Nature, 527, 2015
|
|
3BWA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3bwa by Molmil](/molmil-images/mine/3bwa) | Crystal Structure of HLA B*3508 in complex with a HCMV 8-mer peptide from the pp65 protein | 分子名称: | Beta-2-microglobulin, FPT peptide from 65 kDa lower matrix phosphoprotein, HLA class I histocompatibility antigen, ... | 著者 | Wynn, K.K, Marland, Z, Cooper, L, Silins, S.L, Gras, S, Archbold, J.K, Tynan, F.E, Miles, J.J, McCluskey, J, Burrows, S.R, Rossjohn, J, Khanna, R. | 登録日 | 2008-01-08 | 公開日 | 2008-04-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection Blood, 111, 2008
|
|
4TR9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4tr9 by Molmil](/molmil-images/mine/4tr9) | Ternary co-crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP and a small molecule inhibitor | 分子名称: | ALA-ALA-ALA-SER-LEU-TYR-GLU-LYS-LYS-ALA-ALA, ALA-ALA-SER-LEU-TYR-GLU-LYS-LYS-ALA-ALA, ASP-TRP-ASN, ... | 著者 | Bosch, G, Weltzer, R, O'Malley, K, Bosch, J. | 登録日 | 2014-06-15 | 公開日 | 2015-08-26 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.111 Å) | 主引用文献 | Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex. Malar.J., 14, 2015
|
|
1Z8C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1z8c by Molmil](/molmil-images/mine/1z8c) | Crystal structure of the complex of mutant HIV-1 protease (l63P, A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 | 分子名称: | N-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide, PROTEASE RETROPEPSIN, SULFATE ION | 著者 | Duskova, J, Skalova, T, Dohnalek, J, Petrokova, H, Hasek, J. | 登録日 | 2005-03-30 | 公開日 | 2006-03-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Mutational Study of Pseudopeptide Inhibitor Binding to HIV-1 Protease; Analysis of Four X-ray Structures To be Published
|
|
2F6D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f6d by Molmil](/molmil-images/mine/2f6d) | Structure of the complex of a glucoamylase from Saccharomycopsis fibuligera with acarbose | 分子名称: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, Glucoamylase GLU1, PHOSPHATE ION, ... | 著者 | Sevcik, J, Hostinova, E, Solovicova, A, Gasperik, J, Dauter, Z, Wilson, K.S. | 登録日 | 2005-11-29 | 公開日 | 2006-05-23 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of the complex of a yeast glucoamylase with acarbose reveals the presence of a raw starch binding site on the catalytic domain. Febs J., 273, 2006
|
|
1ZBG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zbg by Molmil](/molmil-images/mine/1zbg) | Crystal structure of a complex of mutant hiv-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 | 分子名称: | CHLORIDE ION, N-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide, PROTEASE RETROPEPSIN, ... | 著者 | Duskova, J, Skalova, T, Dohnalek, J, Petrokova, H, Hasek, J. | 登録日 | 2005-04-08 | 公開日 | 2006-04-18 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | 主引用文献 | Mutational Study of Pseudopeptide Inhibitor Binding to HIV-1 Protease; Analysis of Four X-ray Structures To be Published
|
|
2F8P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f8p by Molmil](/molmil-images/mine/2f8p) | Crystal structure of obelin following Ca2+ triggered bioluminescence suggests neutral coelenteramide as the primary excited state | 分子名称: | CALCIUM ION, N-[3-BENZYL-5-(4-HYDROXYPHENYL)PYRAZIN-2-YL]-2-(4-HYDROXYPHENYL)ACETAMIDE, Obelin | 著者 | Liu, Z.J, Stepanyuk, G.A, Vysotski, E.S, Lee, J, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2005-12-03 | 公開日 | 2006-02-14 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Crystal structure of obelin after Ca2+-triggered bioluminescence suggests neutral coelenteramide as the primary excited state. Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
2EW6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ew6 by Molmil](/molmil-images/mine/2ew6) | Structure of Helicobacter Pylori peptide deformylase in complex with inhibitor | 分子名称: | (2E)-3-(3,4-DIHYDROXYPHENYL)-N-[2-(4-HYDROXYPHENYL)ETHYL]ACRYLAMIDE, COBALT (II) ION, peptide deformylase | 著者 | Cai, J. | 登録日 | 2005-11-02 | 公開日 | 2006-10-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation Protein Sci., 15, 2006
|
|
3CD4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3cd4 by Molmil](/molmil-images/mine/3cd4) | |
2EW5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ew5 by Molmil](/molmil-images/mine/2ew5) | Structure of Helicobacter Pylori peptide deformylase in complex with inhibitor | 分子名称: | 4-{(1E)-3-OXO-3-[(2-PHENYLETHYL)AMINO]PROP-1-EN-1-YL}-1,2-PHENYLENE DIACETATE, COBALT (II) ION, peptide deformylase | 著者 | Cai, J. | 登録日 | 2005-11-02 | 公開日 | 2006-10-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation Protein Sci., 15, 2006
|
|
2F5Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f5y by Molmil](/molmil-images/mine/2f5y) | Crystal Structure of the PDZ Domain from Human RGS-3 | 分子名称: | SULFATE ION, regulator of G-protein signalling 3 isoform 1 | 著者 | Ugochukwu, E, Berridge, G, Johansson, C, Smee, C, Savitsky, P, Burgess, N, Colebrook, S, Yang, X, Elkins, J, Doyle, D, Turnbull, A, Papagrigoriou, E, Debreczeni, J, Bunkoczi, G, Gorrec, F, von Delft, F, Arrowsmith, C, Sundstrom, M, Weigelt, J, Edwards, A, Structural Genomics Consortium (SGC) | 登録日 | 2005-11-28 | 公開日 | 2005-12-13 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Crystal Structure of the PDZ Domain from Human RGS-3 To be Published
|
|
2F77
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f77 by Molmil](/molmil-images/mine/2f77) | Solution structure of the R55F mutant of M-PMV matrix protein (p10) | 分子名称: | Core protein p10 | 著者 | Vlach, J, Lipov, J, Veverka, V, Lang, J, Srb, P, Rumlova, M, Hunter, E, Ruml, T, Hrabal, R. | 登録日 | 2005-11-30 | 公開日 | 2006-12-05 | 最終更新日 | 2024-05-08 | 実験手法 | SOLUTION NMR | 主引用文献 | D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein. Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
6X50
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6x50 by Molmil](/molmil-images/mine/6x50) | Mfd-bound E.coli RNA polymerase elongation complex - V state | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Llewelyn, E, Chen, J, Kang, J.Y, Darst, S.A. | 登録日 | 2020-05-24 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
|
|
6LHS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lhs by Molmil](/molmil-images/mine/6lhs) | High resolution structure of FANCA C-terminal domain (CTD) | 分子名称: | Fanconi anemia complementation group A | 著者 | Jeong, E, Lee, S, Shin, J, Kim, Y, Scharer, O, Kim, Y, Kim, H, Cho, Y. | 登録日 | 2019-12-10 | 公開日 | 2020-03-25 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex. Nucleic Acids Res., 48, 2020
|
|
8BI2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bi2 by Molmil](/molmil-images/mine/8bi2) | Syk kinase domain in complex with macrocyclic inhibitor 20a | 分子名称: | 10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one, Tyrosine-protein kinase SYK | 著者 | Read, J.A, Patel, J. | 登録日 | 2022-11-01 | 公開日 | 2023-06-14 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.508 Å) | 主引用文献 | Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors. Bioorg.Med.Chem.Lett., 91, 2023
|
|
3UZD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3uzd by Molmil](/molmil-images/mine/3uzd) | Crystal structure of 14-3-3 GAMMA | 分子名称: | 14-3-3 protein gamma, Histone deacetylase 4, MAGNESIUM ION, ... | 著者 | Xu, C, Bian, C, MacKenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2011-12-07 | 公開日 | 2012-03-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock. Sci.Signal., 5, 2012
|
|
6TTI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6tti by Molmil](/molmil-images/mine/6tti) | PKM2 in complex with Compound 6 | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, DIMETHYL SULFOXIDE, Pyruvate kinase PKM, ... | 著者 | Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A. | 登録日 | 2019-12-27 | 公開日 | 2020-01-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Fragment-based drug discovery using cryo-EM. Drug Discov Today, 25, 2020
|
|
6L97
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6l97 by Molmil](/molmil-images/mine/6l97) | Complex of DNA polymerase IV and L-DNA duplex | 分子名称: | DNA (5'-D(*(0DG)P*(0DG)P*(0DG)P*(0DG)P*(0DG)P*(0DA)P*(0DA)P*(0DG)P*(0DG)P*(0DA)P*(0DT)P*(0DT)P*(0DC)P*(0DC))-3'), DNA (5'-D(P*(0DG)P*(0DG)P*(0DA)P*(0DA)P*(0DT)P*(0DC)P*(0DC)P*(0DT)P*(0DT)P*(0DC)P*(0DC)P*(0DC)P*(0DC)P*(0DC))-3'), DNA polymerase IV | 著者 | Chung, H.S, An, J, Hwang, D. | 登録日 | 2019-11-08 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.362 Å) | 主引用文献 | The crystal structure of a natural DNA polymerase complexed with mirror DNA. Chem.Commun.(Camb.), 56, 2020
|
|
8TEX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8tex by Molmil](/molmil-images/mine/8tex) | Avian Adeno-associated virus - empty capsid | 分子名称: | Capsid protein | 著者 | Hsi, J, Mietzsch, M, Chipman, P, Afione, S, Zeher, A, Huang, R, Chiorini, J, McKenna, R. | 登録日 | 2023-07-07 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | Structural and antigenic characterization of the avian adeno-associated virus capsid. J.Virol., 97, 2023
|
|
6X26
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6x26 by Molmil](/molmil-images/mine/6x26) | Mfd-bound E.coli RNA polymerase elongation complex - L1 state | 分子名称: | DNA (64-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. | 登録日 | 2020-05-20 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
|
|