8BI2

Syk kinase domain in complex with macrocyclic inhibitor 20a

Summary for 8BI2

Entry DOI	10.2210/pdb8bi2/pdb
Descriptor	Tyrosine-protein kinase SYK, 10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one (3 entities in total)
Functional Keywords	syk kinase transferase inhibitor, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35341.50
Authors	Read, J.A.,Patel, J. (deposition date: 2022-11-01, release date: 2023-06-14, Last modification date: 2023-06-21)
Primary citation	Grimster, N.P.,Gingipalli, L.,Balazs, A.,Barlaam, B.,Boiko, S.,Boyd, S.,Dry, H.,Goldberg, F.W.,Ikeda, T.,Johnson, T.,Kawatkar, S.,Kemmitt, P.,Lamont, S.,Lorthioir, O.,Mfuh, A.,Patel, J.,Pike, A.,Read, J.,Romero, R.,Sarkar, U.,Sha, L.,Simpson, I.,Song, K.,Su, Q.,Wang, H.,Watson, D.,Wu, A.,Zehnder, T.E.,Zheng, X.,Li, S.,Dong, Z.,Yang, D.,Song, Y.,Wang, P.,Liu, X.,Dowling, J.E.,Edmondson, S.D. Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors. Bioorg.Med.Chem.Lett., 91:129352-129352, 2023 Cited by PubMed: 37270074 DOI: 10.1016/j.bmcl.2023.129352 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.508 Å)

Structure validation