Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide

Summary for 4PXQ

DescriptorD-glucuronyl C5 epimerase B, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ... (5 entities in total)
Functional Keywordsepimerization enzyme, multiple domain structure, heparan sulfate c5-epimerase, heparin, heparan sulfate, isomerase
Biological sourceDanio rerio (leopard danio,zebra danio,zebra fish)
Total number of polymer chains2
Total molecular weight135917.35
Ke, J.,Qin, Y.,Gu, X.,Tan, J.,Brunzelle, J.S.,Xu, H.E.,Ding, K. (deposition date: 2014-03-24, release date: 2015-01-14, Last modification date: 2015-03-18)
Primary citation
Qin, Y.,Ke, J.,Gu, X.,Fang, J.,Wang, W.,Cong, Q.,Li, J.,Tan, J.,Brunzelle, J.S.,Zhang, C.,Jiang, Y.,Melcher, K.,Li, J.P.,Xu, H.E.,Ding, K.
Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290:4620-4630, 2015
PubMed: 25568314 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M114.602201
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.222301.9%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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