Crystal structure of the complex of mutant HIV-1 protease (l63P, A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2

Summary for 1Z8C

Related1FQX 1M0B 1LZQ 1IIQ 1ZBG 1ZJ7 1ZLF
Related PRD IDPRD_000385
DescriptorPROTEASE RETROPEPSIN, N-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide, SULFATE ION, ... (4 entities in total)
Functional Keywordshiv, protease, peptidomimetic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Cellular locationGag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P03367
Total number of polymer chains2
Total molecular weight22559.55
Duskova, J.,Skalova, T.,Dohnalek, J.,Petrokova, H.,Hasek, J. (deposition date: 2005-03-30, release date: 2006-03-21, Last modification date: 2017-10-11)
Primary citation
Duskova, J.,Skalova, T.,Dohnalek, J.,Petrokova, H.,Hasek, J.
Mutational Study of Pseudopeptide Inhibitor Binding to HIV-1 Protease; Analysis of Four X-ray Structures
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.168803.0%1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-07-29