1LZQ

Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with an ethylenamine peptidomimetic inhibitor BOC-PHE-PSI[CH2CH2NH]-PHE-GLU-PHE-NH2

Summary for 1LZQ

Entry DOI	10.2210/pdb1lzq/pdb
Related	1FQX 1IIQ 1M0B
Related PRD ID	PRD_000383
Descriptor	PROTEASE RETROPEPSIN, N-{(3S)-3-[(tert-butoxycarbonyl)amino]-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide, BETA-MERCAPTOETHANOL, ... (4 entities in total)
Functional Keywords	hiv, peptidomimetic, ethylenamine isostere, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	2
Total formula weight	22405.47
Authors	Skalova, T.,Hasek, J.,Dohnalek, J.,Petrokova, H.,Buchtelova, E.,Soucek, M.,Majer, P.,Uhlikova, T.,Konvalinka, J. (deposition date: 2002-06-11, release date: 2003-04-29, Last modification date: 2024-02-14)
Primary citation	Skalova, T.,Hasek, J.,Dohnalek, J.,Petrokova, H.,Buchtelova, E.,Duskova, J.,Soucek, M.,Majer, P.,Uhlikova, T.,Konvalinka, J. An Ethylenamine Inhibitor Binds Tightly to Both Wild Type and Mutant HIV-1 Proteases. Structure and Energy Study J.Med.Chem., 46:1636-1644, 2003 Cited by PubMed: 12699382 DOI: 10.1021/jm021079g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation