1Z8C
Crystal structure of the complex of mutant HIV-1 protease (l63P, A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEASE RETROPEPSIN | polymer | 99 | 10879.8 | 2 | UniProt (P03367) Pfam (PF00077) UniProt (by SIFTS) (Q9JAU9) | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | C (A) | N-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide | non-polymer | 703.8 | 1 | BIRD (PRD_000385) Chemie (0ZS) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Pro 63 | Leu 131 | engineered mutation |
| Val 71 | Ala 139 | engineered mutation |
| Thr 82 | Val 150 | engineered mutation |
| Val 84 | Ile 152 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21759.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 799.9 | |
| All* | Total formula weight | 22559.5 |
