4UPG
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5EBK
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4USL
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![BU of 4usl by Molmil](/molmil-images/mine/4usl) | The X-ray structure of calcium bound human sorcin | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, SORCIN, ... | Authors: | Ilari, A, Fiorillo, A, Colotti, G. | Deposit date: | 2014-07-10 | Release date: | 2015-07-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural Basis of Sorcin-Mediated Calcium-Dependent Signal Transduction. Sci.Rep., 5, 2015
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6ER5
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6RB5
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![BU of 6rb5 by Molmil](/molmil-images/mine/6rb5) | Trypanothione reductase in complex with 4-(((3-(8-(2-((1R,2S,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)ethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)propyl)(methyl)amino)methyl)-4-hydroxypiperidine-1-carboximidamide | Descriptor: | 4-(((3-(8-(2-((1R,2S,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)ethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)propyl)(methyl)amino)methyl)-4-hydroxypiperidine-1-carboximidamide, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Ilari, A, Fiorillo, A, Battista, T, Mocci, S. | Deposit date: | 2019-04-09 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.977 Å) | Cite: | Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme. Plos Negl Trop Dis, 14, 2020
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6Y75
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![BU of 6y75 by Molmil](/molmil-images/mine/6y75) | BIL2 domain from T.thermophila BUBL1 locus (C1A-N143A) | Descriptor: | DI(HYDROXYETHYL)ETHER, FORMIC ACID, NAD(P)(+)--arginine ADP-ribosyltransferase, ... | Authors: | Ilari, A, Chiarini, V. | Deposit date: | 2020-02-28 | Release date: | 2021-02-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis of ubiquitination mediated by protein splicing in early Eukarya. Biochim Biophys Acta Gen Subj, 1865, 2021
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5O7D
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![BU of 5o7d by Molmil](/molmil-images/mine/5o7d) | The X-ray structure of human R38M phosphoglycerate kinase 1 mutant | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Phosphoglycerate kinase 1 | Authors: | Ilari, A, Fiorillo, A, Cipollone, A, Petrosino, M. | Deposit date: | 2017-06-08 | Release date: | 2018-06-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme. PLoS ONE, 13, 2018
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5M3U
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![BU of 5m3u by Molmil](/molmil-images/mine/5m3u) | The X-ray structure of human V216F phosphoglycerate kinase 1 mutant | Descriptor: | 3-PHOSPHOGLYCERIC ACID, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ilari, A, Fiorillo, A, Cipollone, A, Petrosino, M. | Deposit date: | 2016-10-17 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme. PLoS ONE, 13, 2018
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5MXM
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![BU of 5mxm by Molmil](/molmil-images/mine/5mxm) | The X-ray structure of human M190I phosphoglycerate kinase 1 mutant | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-PHOSPHOGLYCERIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Ilari, A, Fiorillo, A, Cipollone, A, Petrosino, M. | Deposit date: | 2017-01-23 | Release date: | 2018-02-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme. PLoS ONE, 13, 2018
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5M6Z
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![BU of 5m6z by Molmil](/molmil-images/mine/5m6z) | The X-ray structure of human M189I PGK-1 mutant in partially closed conformation | Descriptor: | 3-PHOSPHOGLYCERIC ACID, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ilari, A, Fiorillo, A, Petrosino, M, Cipollone, A. | Deposit date: | 2016-10-26 | Release date: | 2017-11-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme. PLoS ONE, 13, 2018
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5M1R
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![BU of 5m1r by Molmil](/molmil-images/mine/5m1r) | X-ray structure of human G166D PGK-1 mutant | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphoglycerate kinase 1 | Authors: | Ilari, A, Cipollone, A, Fiorillo, A, Petrosino, M. | Deposit date: | 2016-10-10 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme. PLoS ONE, 13, 2018
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5MRA
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![BU of 5mra by Molmil](/molmil-images/mine/5mra) | human SCBD (sorcin calcium binding domain) in complex with doxorubicin | Descriptor: | DIMETHYL SULFOXIDE, DOXORUBICIN, MAGNESIUM ION, ... | Authors: | Ilari, A, Fiorillo, A, Colotti, G, Genovese, I. | Deposit date: | 2016-12-22 | Release date: | 2017-11-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.74 Å) | Cite: | Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells. Cell Death Dis, 8, 2017
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4K1F
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![BU of 4k1f by Molmil](/molmil-images/mine/4k1f) | Crystal structure of reduced tryparedoxin peroxidase from leishmania major at 2.34 A resolution | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Ilari, A, Fiorillo, A, Di Chiaro, F. | Deposit date: | 2013-04-05 | Release date: | 2014-04-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking Sci Rep, 5, 2015
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1O9R
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![BU of 1o9r by Molmil](/molmil-images/mine/1o9r) | The X-ray crystal structure of Agrobacterium tumefaciens Dps, a member of the family that protect DNA without binding | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AGROBACTERIUM TUMEFACIENS DPS, ... | Authors: | Ilari, A, Ceci, P, Chiancone, E. | Deposit date: | 2002-12-18 | Release date: | 2003-05-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The Dps Protein of Agrobacterium Tumefaciens Does not Bind to DNA But Protects It Toward Oxidative Cleavage: X-Ray Crystal Structure, Iron Binding, and Hydroxyl-Radical Scavenging Properties J.Biol.Chem., 278, 2003
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1GVH
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![BU of 1gvh by Molmil](/molmil-images/mine/1gvh) | The X-ray structure of ferric Escherichia coli flavohemoglobin reveals an unespected geometry of the distal heme pocket | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, FLAVOHEMOPROTEIN, ... | Authors: | Ilari, A, Johnson, K.A, Bonamore, A, Farina, A, Boffi, A. | Deposit date: | 2002-02-13 | Release date: | 2002-08-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | The X-Ray Structure of Ferric Escherichia Coli Flavohemoglobin Reveals an Unexpected Geometry of the Distal Heme Pocket J.Biol.Chem., 277, 2002
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1GJY
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![BU of 1gjy by Molmil](/molmil-images/mine/1gjy) | The X-ray structure of the Sorcin Calcium Binding Domain (SCBD) provides insight into the phosphorylation and calcium dependent processess | Descriptor: | SORCIN, SULFATE ION | Authors: | Ilari, A, Johnson, K.A, Nastopoulos, V, Tsernoglou, D, Chiancone, E. | Deposit date: | 2001-08-06 | Release date: | 2002-04-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Crystal Structure of the Sorcin Calcium Binding Domain Provides a Model of Ca(2+)-Dependent Processes in the Full-Length Protein J.Mol.Biol., 317, 2002
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1UX8
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![BU of 1ux8 by Molmil](/molmil-images/mine/1ux8) | X-ray structure of truncated oxygen-avid haemoglobin from Bacillus subtilis | Descriptor: | CHLORIDE ION, CYANIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Ilari, A, Giangiacomo, L, Boffi, A, Chiancone, E. | Deposit date: | 2004-02-20 | Release date: | 2004-12-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The Truncated Oxygen-Avid Hemoglobin from Bacillus Subtilis: X-Ray Structure and Ligand Binding Properties J.Biol.Chem., 280, 2005
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1QGH
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![BU of 1qgh by Molmil](/molmil-images/mine/1qgh) | THE X-RAY STRUCTURE OF THE UNUSUAL DODECAMERIC FERRITIN FROM LISTERIA INNOCUA, REVEALS A NOVEL INTERSUBUNIT IRON BINDING SITE. | Descriptor: | FE (III) ION, NON-HEME IRON-CONTAINING FERRITIN | Authors: | Ilari, A, Stefanini, S, Chiancone, E, Tsernoglou, D. | Deposit date: | 1999-04-27 | Release date: | 2000-01-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site. Nat.Struct.Biol., 7, 2000
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2VNE
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![BU of 2vne by Molmil](/molmil-images/mine/2vne) | The X-ray structure of Norcoclaurine synthase from Thalictrum flavum | Descriptor: | S-NORCOCLAURINE SYNTHASE | Authors: | Ilari, A, Franceschini, S, Boffi, A, Bonamore, A, Pasquo, A. | Deposit date: | 2008-02-04 | Release date: | 2008-08-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Structural Basis of Enzymatic S-Norcoclaurine Biosynthesis. J.Biol.Chem., 284, 2009
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1UVH
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![BU of 1uvh by Molmil](/molmil-images/mine/1uvh) | X-ray structure of Dps from Mycobacterium smegmatis | Descriptor: | FE (III) ION, STARVATION-INDUCED DNA PROTECTING PROTEIN | Authors: | Ilari, A, Ceci, P, Falvo, E, Chiancone, E. | Deposit date: | 2004-01-20 | Release date: | 2005-02-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Reassessment of Protein Stability, DNA Binding, and Protection of Mycobacterium Smegmatis Dps. J.Biol.Chem., 280, 2005
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2BMM
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![BU of 2bmm by Molmil](/molmil-images/mine/2bmm) | X-ray structure of a novel thermostable hemoglobin from the actinobacterium Thermobifida fusca | Descriptor: | ACETATE ION, PROTOPORPHYRIN IX CONTAINING FE, THERMOSTABLE HEMOGLOBIN FROM THERMOBIFIDA FUSCA | Authors: | Ilari, A, Franceschini, S, Bonamore, A, Boffi, A. | Deposit date: | 2005-03-15 | Release date: | 2005-07-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | A Novel Thermostable Hemoglobin from the Actinobacterium Thermobifida Fusca. FEBS J., 272, 2005
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2IY4
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![BU of 2iy4 by Molmil](/molmil-images/mine/2iy4) | X-ray structure of Dps from Listeria monocytogenes | Descriptor: | FE (III) ION, NON-HEME IRON-CONTAINING FERRITIN | Authors: | Ilari, A, Bellapadrona, G, Stefanini, S, Chiancone, E. | Deposit date: | 2006-07-12 | Release date: | 2007-01-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | The Mutations Lys 114 --> Gln and Asp 126 --> Asn Disrupt an Intersubunit Salt Bridge and Convert Listeria Innocua Dps Into its Natural Mutant Listeria Monocytogenes Dps. Effects on Protein Stability at Low Ph. Proteins, 66, 2007
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2VQ5
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![BU of 2vq5 by Molmil](/molmil-images/mine/2vq5) | X-ray structure of Norcoclaurine synthase from Thalictrum flavum in complex with dopamine and hydroxybenzaldehyde | Descriptor: | ACETATE ION, CHLORIDE ION, L-DOPAMINE, ... | Authors: | Ilari, A, Franceschini, S, Bonamore, A, Boffi, A. | Deposit date: | 2008-03-11 | Release date: | 2008-08-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structural Basis of Enzymatic S-Norcoclaurine Biosynthesis. J.Biol.Chem., 284, 2009
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2UZZ
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![BU of 2uzz by Molmil](/molmil-images/mine/2uzz) | X-ray structure of N-methyl-L-tryptophan oxidase (MTOX) | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, N-METHYL-L-TRYPTOPHAN OXIDASE, SODIUM ION | Authors: | Ilari, A, Fiorillo, A, Franceschini, S, Bonamore, A, Colotti, G, Boffi, A. | Deposit date: | 2007-05-03 | Release date: | 2008-01-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The X-Ray Structure of N-Methyltryptophan Oxidase Reveals the Structural Determinants of Substrate Specificity. Proteins, 71, 2008
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2BK6
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![BU of 2bk6 by Molmil](/molmil-images/mine/2bk6) | The X-ray crystal structure of the Listeria innocua H31G Dps mutant. | Descriptor: | NON-HEME IRON-CONTAINING FERRITIN | Authors: | Ilari, A, Latella, M.C, Ribacchi, F, Su, M, Giangiacomo, L, Stefanini, S, Chasteen, N.D, Chiancone, E. | Deposit date: | 2005-02-11 | Release date: | 2005-02-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | The unusual intersubunit ferroxidase center of Listeria innocua Dps is required for hydrogen peroxide detoxification but not for iron uptake. A study with site-specific mutants. Biochemistry, 44, 2005
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