6RB5

Trypanothione reductase in complex with 4-(((3-(8-(2-((1R,2S,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)ethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)propyl)(methyl)amino)methyl)-4-hydroxypiperidine-1-carboximidamide

Summary for 6RB5

• Entry DOI: 10.2210/pdb6rb5/pdb
• Descriptor: Trypanothione reductase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... (6 entities in total)
• Functional Keywords: oxidoreductase, trypanothione metabolism, antioxidant, trypanosoma brucei
• Biological source: Trypanosoma brucei
• Total number of polymer chains: 2
• Total formula weight: 116289.88

Authors

Ilari, A.,Fiorillo, A.,Battista, T.,Mocci, S. (deposition date: 2019-04-09, release date: 2020-05-13, Last modification date: 2024-01-24)

• Primary citation: Turcano, L.,Battista, T.,De Haro, E.T.,Missineo, A.,Alli, C.,Paonessa, G.,Colotti, G.,Harper, S.,Fiorillo, A.,Ilari, A.,Bresciani, A.; Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.; Plos Negl Trop Dis, 14:e0008339-e0008339, 2020; PubMed: 32437349; DOI: 10.1371/journal.pntd.0008339

Experimental method

X-RAY DIFFRACTION (1.977 Å)