6GNS
 
 | | Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and an Azepanyl Phenyl Benzylsulphonamide Ligand | | Descriptor: | Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, methyl 4-(azepan-1-yl)-3-[[4-[4-(1-methylpiperidin-4-yl)butyl]phenyl]sulfonylamino]benzoate | | Authors: | Robinson, D.A, Harrison, J.R, Brand, S, Smith, V.C, Thompson, S, Smith, A, Davies, K, Mok, N.Y, Torrie, L.S, Collie, I, Hallyburton, I, Norval, S, Simeons, F.R.C, Stojanovski, L, Frearson, J.A, Brenk, R, Wyatt, P.G, Gilbert, I.H, Read, K.D. | | Deposit date: | 2018-05-31 | | Release date: | 2018-09-26 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.
J. Med. Chem., 61, 2018
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8ASY
 | | SARS-CoV-2 Omicron BA.2.75 RBD in complex with ACE2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | | Authors: | Zhou, D, Huo, J, Ren, J, Stuart, D.I. | | Deposit date: | 2022-08-22 | | Release date: | 2023-01-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75.
Cell Rep, 42, 2022
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6O3L
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6O41
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1SPP
 | | THE CRYSTAL STRUCTURES OF TWO MEMBERS OF THE SPERMADHESIN FAMILY REVEAL THE FOLDING OF THE CUB DOMAIN | | Descriptor: | MAJOR SEMINAL PLASMA GLYCOPROTEIN PSP-I, MAJOR SEMINAL PLASMA GLYCOPROTEIN PSP-II | | Authors: | Romero, A, Romao, M.J, Varela, P.F, Kolln, I, Dias, J.M, Carvalho, A.L, Sanz, L, Topfer-Petersen, E, Calvete, J.J. | | Deposit date: | 1997-06-19 | | Release date: | 1998-06-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The crystal structures of two spermadhesins reveal the CUB domain fold.
Nat.Struct.Biol., 4, 1997
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1BIX
 | | THE CRYSTAL STRUCTURE OF THE HUMAN DNA REPAIR ENDONUCLEASE HAP1 SUGGESTS THE RECOGNITION OF EXTRA-HELICAL DEOXYRIBOSE AT DNA ABASIC SITES | | Descriptor: | AP ENDONUCLEASE 1, PLATINUM (II) ION, SAMARIUM (III) ION | | Authors: | Gorman, M.A, Morera, S, Rothwell, D.G, De La Fortelle, E, Mol, C.D, Tainer, J.A, Hickson, I.D, Freemont, P.S. | | Deposit date: | 1998-06-19 | | Release date: | 1999-06-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.
EMBO J., 16, 1997
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5ADP
 | | Crystal structure of the A.17 antibody FAB fragment - Light chain S35R mutant | | Descriptor: | FAB A.17 | | Authors: | Chatziefthimiou, S.D, Smirnov, I.V, Golovin, A.V, Stepanova, A.V, Peng, Y, Zolotareva, O.I, Belogurov, A.A, Ponomarenko, N.A, Blackburn, G.M, Gabibov, A.A, Lerner, R, Wilmanns, M. | | Deposit date: | 2015-08-21 | | Release date: | 2016-11-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Robotic Qm/Mm-Driven Maturation of Antibody Combining Sites.
Sci.Adv., 2, 2016
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3CJK
 | | Crystal structure of the adduct HAH1-Cd(II)-MNK1. | | Descriptor: | CADMIUM ION, Copper transport protein ATOX1, Copper-transporting ATPase 1 | | Authors: | Banci, L, Bertini, I, Calderone, V, Felli, I, Della-Malva, N, Pavelkova, A, Rosato, A. | | Deposit date: | 2008-03-13 | | Release date: | 2008-12-30 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces.
Biochem.J., 422, 2009
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2JHN
 | | 3-methyladenine dna-glycosylase from Archaeoglobus fulgidus | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-METHYLADENINE DNA-GLYCOSYLASE, GLYCEROL, ... | | Authors: | Leiros, I, Nabong, M.P, Grosvik, K, Ringvoll, J, Haugland, G.T, Uldal, L, Reite, K, Olsbu, I.K, Knaevelsrud, I, Moe, E, Andersen, O.A, Birkeland, N.K, Ruoff, P, Klungland, A, Bjelland, S. | | Deposit date: | 2007-02-22 | | Release date: | 2007-04-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis for Enzymatic Excision of N1-Methyladenine and N3-Methylcytosine from DNA
Embo J., 26, 2007
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1LDP
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7TPG
 | | Single-Particle Cryo-EM Structure of the WaaL O-antigen ligase in its ligand bound state | | Descriptor: | Fab Heavy (H) Chain, Fab Light (L) Chain, GERANYL DIPHOSPHATE, ... | | Authors: | Ashraf, K.U, Nygaard, R, Vickery, O.N, Erramilli, S.K, Herrera, C.M, McConville, T.H, Petrou, V.I, Giacometti, S.I, Dufrisne, M.B, Nosol, K, Zinkle, A.P, Graham, C.L.B, Loukeris, M, Kloss, B, Skorupinska-Tudek, K, Swiezewska, E, Roper, D, Clarke, O.B, Uhlemann, A.C, Kossiakoff, A.A, Trent, M.S, Stansfeld, P.J, Mancia, F. | | Deposit date: | 2022-01-25 | | Release date: | 2022-04-06 | | Last modified: | 2022-04-27 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Structural basis of lipopolysaccharide maturation by the O-antigen ligase.
Nature, 604, 2022
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1BZF
 | | NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES | | Descriptor: | DIHYDROFOLATE REDUCTASE, TRIMETREXATE | | Authors: | Polshakov, V.I, Birdsall, B, Frenkiel, T.A, Gargaro, A.R, Feeney, J. | | Deposit date: | 1998-10-28 | | Release date: | 1999-05-18 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure and dynamics in solution of the complex of Lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate.
Protein Sci., 8, 1999
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7TPJ
 | | Single-Particle Cryo-EM Structure of the WaaL O-antigen ligase in its apo state | | Descriptor: | Fab Heavy (H) Chain, Fab Light (L) Chain, Putative cell surface polysaccharide polymerase/ligase | | Authors: | Ashraf, K.U, Nygaard, R, Vickery, O.N, Erramilli, S.K, Herrera, C.M, McConville, T.H, Petrou, V.I, Giacometti, S.I, Dufrisne, M.B, Nosol, K, Zinkle, A.P, Graham, C.L.B, Loukeris, M, Kloss, B, Skorupinska-Tudek, K, Swiezewska, E, Roper, D, Clarke, O.B, Uhlemann, A.C, Kossiakoff, A.A, Trent, M.S, Stansfeld, P.J, Mancia, F. | | Deposit date: | 2022-01-25 | | Release date: | 2022-04-06 | | Last modified: | 2022-04-27 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Structural basis of lipopolysaccharide maturation by the O-antigen ligase.
Nature, 604, 2022
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5AA3
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6GNU
 | | Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a Quionlinyl aryl sulphonamide ligand | | Descriptor: | 4-[4-(1-methylpiperidin-4-yl)butyl]-~{N}-[6-(2-methylpropyl)quinolin-5-yl]benzenesulfonamide, Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA | | Authors: | Robinson, D.A, Harrison, J.R, Brand, S, Smith, V.C, Thompson, S, Smith, A, Davies, K, Mok, N.Y, Torrie, L.S, Collie, I, Hallyburton, I, Norval, S, Simeons, F.R.C, Stojanovski, L, Frearson, J.A, Brenk, R, Wyatt, P.G, Gilbert, I.H, Read, K.D. | | Deposit date: | 2018-05-31 | | Release date: | 2018-09-26 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.
J. Med. Chem., 61, 2018
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1CT8
 | | CATALYTIC ANTIBODY 7C8 COMPLEX | | Descriptor: | 7C8 FAB FRAGMENT; LONG CHAIN, 7C8 FAB FRAGMENT; SHORT CHAIN, SULFATE ION, ... | | Authors: | Gigant, B, Tsumuraya, T, Fujii, I, Knossow, M. | | Deposit date: | 1999-08-20 | | Release date: | 1999-11-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Diverse structural solutions to catalysis in a family of antibodies.
Structure Fold.Des., 7, 1999
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7U2E
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody ADI-55688 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-55688 heavy chain, ADI-55688 light chain, ... | | Authors: | Yuan, M, Zhu, X, Wilson, I.A. | | Deposit date: | 2022-02-23 | | Release date: | 2022-05-04 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | A broad and potent neutralization epitope in SARS-related coronaviruses.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6GNT
 | | Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a Quionlinyl aryl sulphonamide ligand | | Descriptor: | 4-[4-(1-methylpiperidin-4-yl)butyl]-~{N}-(6-pyrrolidin-1-ylquinolin-5-yl)benzenesulfonamide, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase, ... | | Authors: | Robinson, D.A, Harrison, J.R, Brand, S, Smith, V.C, Thompson, S, Smith, A, Davies, K, Mok, N.Y, Torrie, L.S, Collie, I, Hallyburton, I, Norval, S, Simeons, F.R.C, Stojanovski, L, Frearson, J.A, Brenk, R, Wyatt, P.G, Gilbert, I.H, Read, K.D. | | Deposit date: | 2018-05-31 | | Release date: | 2018-09-26 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.
J. Med. Chem., 61, 2018
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1CH4
 | | MODULE-SUBSTITUTED CHIMERA HEMOGLOBIN BETA-ALPHA (F133V) | | Descriptor: | CARBON MONOXIDE, MODULE-SUBSTITUTED CHIMERA HEMOGLOBIN BETA-ALPHA, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Shirai, T, Fujikake, M, Yamane, T, Inaba, K, Ishimori, K, Morishima, I. | | Deposit date: | 1998-06-11 | | Release date: | 1999-04-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of a protein with an artificial exon-shuffling, module M4-substituted chimera hemoglobin beta alpha, at 2.5 A resolution.
J.Mol.Biol., 287, 1999
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2N81
 | | Solution Structure of Lipid Transfer Protein From Pea Pisum Sativum | | Descriptor: | Lipid Transfer Protein | | Authors: | Paramonov, A.S, Rumynskiy, E.I, Bogdanov, I.V, Finkina, E.I, Melnikova, D.N, Ovchinnikova, T.V, Shenkarev, Z.O, Arseniev, A.S. | | Deposit date: | 2015-09-30 | | Release date: | 2016-05-11 | | Last modified: | 2017-12-20 | | Method: | SOLUTION NMR | | Cite: | A novel lipid transfer protein from the pea Pisum sativum: isolation, recombinant expression, solution structure, antifungal activity, lipid binding, and allergenic properties.
BMC Plant Biol, 16
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2GQM
 | | Solution structure of Human Cu(I)-Sco1 | | Descriptor: | COPPER (I) ION, SCO1 protein homolog, mitochondrial | | Authors: | Banci, L, Bertini, I, Calderone, V, Ciofi-Baffoni, S, Mangani, S, Palumaa, P, Martinelli, M, Wang, S, Structural Proteomics in Europe (SPINE) | | Deposit date: | 2006-04-21 | | Release date: | 2006-06-06 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | A hint for the function of human Sco1 from different structures.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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1KQK
 | | Solution Structure of the N-terminal Domain of a Potential Copper-translocating P-type ATPase from Bacillus subtilis in the Cu(I)loaded State | | Descriptor: | COPPER (I) ION, POTENTIAL COPPER-TRANSPORTING ATPASE | | Authors: | Banci, L, Bertini, I, Ciofi-Baffoni, S, D'Onofrio, M, Gonnelli, L, Marhuenda-Egea, F.C, Ruiz-Duenas, F.J. | | Deposit date: | 2002-01-07 | | Release date: | 2002-04-17 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the N-terminal domain of a potential copper-translocating P-type ATPase from Bacillus subtilis in the apo and Cu(I) loaded states.
J.Mol.Biol., 317, 2002
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2GT6
 | | Solution structure of Human Cu(I) Sco1 | | Descriptor: | COPPER (I) ION, SCO1 protein homolog, mitochondrial | | Authors: | Banci, L, Bertini, I, Calderone, V, Ciofi-Baffoni, S, Mangani, S, Palumaa, P, Martinelli, M, Wang, S, Structural Proteomics in Europe (SPINE) | | Deposit date: | 2006-04-27 | | Release date: | 2006-06-06 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | A hint for the function of human Sco1 from different structures.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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3FON
 | | Crystal structure of the Class I MHC Molecule H-2Kwm7 with a Single Self Peptide VNDIFEAI | | Descriptor: | Beta-2-microglobulin, MHC, Peptide | | Authors: | Malashkevich, V.N, Qian, J, Jarchum, I, Yamada, T, Mikesh, L, Palmieri, E, Lund, T, Hattori, M, Shabanowitz, J, Hunt, D.F, Ramagopal, U.A, Brims, D.R, Almo, S.C, Nathenson, S.G, DiLorenzo, T.P. | | Deposit date: | 2008-12-30 | | Release date: | 2010-01-12 | | Last modified: | 2020-02-05 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.
Int.Immunol., 22, 2010
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1QLR
 | | CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A HUMAN MONOCLONAL IgM COLD AGGLUTININ | | Descriptor: | IGM FAB REGION IV-J(H4)-C (KAU COLD AGGLUTININ), IGM KAPPA CHAIN V-III (KAU COLD AGGLUTININ), alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Carvalho, J.G, Cauerhff, A, Goldbaum, F, Leoni, J, Polikarpov, I. | | Deposit date: | 1999-09-11 | | Release date: | 2000-09-14 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.83 Å) | | Cite: | Three-dimensional structure of the Fab from a human IgM cold agglutinin.
J Immunol., 165, 2000
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