1X8B
| Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824 | 分子名称: | 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, MAGNESIUM ION, Wee1-like protein kinase | 著者 | Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N. | 登録日 | 2004-08-17 | 公開日 | 2005-06-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation Structure, 13, 2005
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1X8V
| Estriol-bound and ligand-free structures of sterol 14alpha-demethylase (CYP51) | 分子名称: | Cytochrome P450 51, ESTRIOL, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Podust, L.M, Yermalitskaya, L.V, Lepesheva, G.I, Podust, V.N, Dalmasso, E.A, Waterman, M.R. | 登録日 | 2004-08-18 | 公開日 | 2004-11-23 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Estriol Bound and Ligand-free Structures of Sterol 14alpha-Demethylase. Structure, 12, 2004
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1X97
| Crystal structure of Aldose Reductase complexed with 2R4S (Stereoisomer of Fidarestat, 2S4S) | 分子名称: | (2R,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Aldose Reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | El-Kabbani, O, Darmanin, C, Oka, M, Schulze-Briese, C, Tomizaki, T, Hazemann, I, Mitschler, A, Podjarny, A. | 登録日 | 2004-08-19 | 公開日 | 2004-09-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor J.Med.Chem., 47, 2004
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1LOI
| N-TERMINAL SPLICE REGION OF RAT C-AMP PHOSPHODIESTERASE, NMR, 7 STRUCTURES | 分子名称: | CYCLIC 3',5'-AMP SPECIFIC PHOSPHODIESTERASE RD1 | 著者 | Smith, K.J, Scotland, G, Beattie, J, Trayer, I.P, Houslay, M.D. | 登録日 | 1996-05-21 | 公開日 | 1997-05-15 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs. J.Biol.Chem., 271, 1996
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1QD5
| OUTER MEMBRANE PHOSPHOLIPASE A FROM ESCHERICHIA COLI | 分子名称: | OUTER MEMBRANE PHOSPHOLIPASE A, octyl beta-D-glucopyranoside | 著者 | Snijder, H.J, Ubarretxena-Belandia, I, Blaauw, M, Kalk, K.H, Verheij, H.M, Egmond, M.R, Dekker, N, Dijkstra, B.W. | 登録日 | 1999-07-09 | 公開日 | 1999-10-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Structural evidence for dimerization-regulated activation of an integral membrane phospholipase. Nature, 401, 1999
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1XBV
| Crystal structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound D-ribulose 5-phosphate | 分子名称: | 3-keto-L-gulonate 6-phosphate decarboxylase, MAGNESIUM ION, RIBULOSE-5-PHOSPHATE | 著者 | Wise, E.L, Yew, W.S, Akana, J, Gerlt, J.A, Rayment, I. | 登録日 | 2004-08-31 | 公開日 | 2005-04-26 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: structural basis for catalytic promiscuity in wild-type and designed mutants of 3-keto-L-gulonate 6-phosphate decarboxylase Biochemistry, 44, 2005
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1QDS
| SUPERSTABLE E65Q MUTANT OF LEISHMANIA MEXICANA TRIOSEPHOSPHATE ISOMERASE (TIM) | 分子名称: | 2-PHOSPHOGLYCOLIC ACID, TRIOSEPHOSPHATE ISOMERASE | 著者 | Lambeir, A.M, Backmann, J, Ruiz-Sanz, J, Filimonov, V, Nielsen, J.E, Vriend, G, Kursula, I, Norledge, B.V, Wierenga, R.K. | 登録日 | 1999-07-10 | 公開日 | 2000-12-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The ionization of a buried glutamic acid is thermodynamically linked to the stability of Leishmania mexicana triose phosphate isomerase. Eur.J.Biochem., 267, 2000
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1X96
| Crystal structure of Aldose Reductase with citrates bound in the active site | 分子名称: | CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, aldose reductase | 著者 | El-Kabbani, O, Darmanin, C, Oka, M, Schulze-Briese, C, Tomizaki, T, Hazemann, I, Mitschler, A, Podjarny, A. | 登録日 | 2004-08-19 | 公開日 | 2004-09-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor J.Med.Chem., 47, 2004
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1LKI
| THE CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTION OF LEUKEMIA INHIBITORY FACTOR: IMPLICATIONS FOR RECEPTOR BINDING | 分子名称: | LEUKEMIA INHIBITORY FACTOR | 著者 | Robinson, R.C, Grey, L.M, Staunton, D, Stuart, D.I, Heath, J.K, Jones, E.Y. | 登録日 | 1994-12-12 | 公開日 | 1995-03-31 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. Cell(Cambridge,Mass.), 77, 1994
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1XAH
| CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD+ | 分子名称: | 3-dehydroquinate synthase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION | 著者 | Nichols, C.E, Ren, J, Leslie, K, Dhaliwal, B, Lockyer, M, Charles, I, Hawkins, A.R, Stammers, D.K. | 登録日 | 2004-08-25 | 公開日 | 2005-03-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Comparison of ligand induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases. J.Mol.Biol., 343, 2004
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1Q6L
| Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate | 分子名称: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-THREONOHYDROXAMATE 4-PHOSPHATE, MAGNESIUM ION | 著者 | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | 登録日 | 2003-08-13 | 公開日 | 2003-10-28 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Evidence for a 1,2-Enediolate Intermediate in the Reaction Catalyzed by 3-Keto-l-Gulonate 6-Phosphate Decarboxylase, a Member of the Orotidine 5'-Monophosphate Decarboxylase Suprafamily Biochemistry, 42, 2003
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3LPZ
| Crystal structure of C. therm. Get4 | 分子名称: | Uncharacterized protein | 著者 | Bozkurt, G, Wild, K, Sinning, I. | 登録日 | 2010-02-08 | 公開日 | 2010-03-16 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis. Febs Lett., 584, 2010
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1XAR
| Crystal Structure of a fragment of DC-SIGNR (containing the carbohydrate recognition domain and two repeats of the neck). | 分子名称: | CD209 antigen-like protein 1, SODIUM ION | 著者 | Feinberg, H, Guo, Y, Mitchell, D.A, Drickamer, K, Weis, W.I. | 登録日 | 2004-08-26 | 公開日 | 2004-11-16 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Extended Neck Regions Stabilize Tetramers of the Receptors DC-SIGN and DC-SIGNR J.Biol.Chem., 280, 2005
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1LXC
| Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Acrylamide Inhibitor | 分子名称: | 3-(6-AMINOPYRIDIN-3-YL)-N-METHYL-N-[(1-METHYL-1H-INDOL-2-YL)METHYL]ACRYLAMIDE, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Miller, W.H, Seefeld, M.A, Newlander, K.A, Uzinskas, I.N, Burgess, W.J, Heerding, D.A, Yuan, C.C.K, Head, M.S, Payne, D.J, Rittenhouse, S.F, Moore, T.D, Pearson, S.C, Dewolf, V, Berry, W.E, Keller, P.M, Polizzi, B.J, Qiu, X, Janson, C.A, Huffman, W.F. | 登録日 | 2002-06-05 | 公開日 | 2002-09-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). J.Med.Chem., 45, 2002
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1M9F
| X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M Complex. | 分子名称: | Cyclophilin A, HIV-1 Capsid | 著者 | Howard, B.R, Vajdos, F.F, Li, S, Sundquist, W.I, Hill, C.P. | 登録日 | 2002-07-28 | 公開日 | 2003-05-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Structural insights into the catalytic mechanism of cyclophilin A Nat.Struct.Biol., 10, 2003
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1M4P
| Structure of the Tsg101 UEV domain in complex with a HIV-1 PTAP "late domain" peptide, DYANA Ensemble | 分子名称: | Gag Polyprotein, Tumor Susceptibility gene 101 protein | 著者 | Pornillos, O, Alam, S.L, Davis, D.R, Sundquist, W.I. | 登録日 | 2002-07-03 | 公開日 | 2002-11-06 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein Nat.Struct.Biol., 9, 2002
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1XA5
| Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid | 分子名称: | 3"-(BETA-CHLOROETHYL)-2",4"-DIOXO-3, 5"-SPIRO-OXAZOLIDINO-4-DEACETOXY-VINBLASTINE, CALCIUM ION, ... | 著者 | Horvath, I, Harmat, V, Hlavanda, E, Naray-Szabo, G, Ovadi, J. | 登録日 | 2004-08-25 | 公開日 | 2004-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug J.Biol.Chem., 280, 2005
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1XBA
| Crystal structure of apo syk tyrosine kinase domain | 分子名称: | Tyrosine-protein kinase SYK | 著者 | Atwell, S, Adams, J.M, Badger, J, Buchanan, M.D, Feil, I.K, Froning, K.J, Gao, X, Hendle, J, Keegan, K, Leon, B.C, Muller-Deickmann, H.J, Nienaber, V.L, Noland, B.W, Post, K, Rajashankar, K.R, Ramos, A, Russell, M, Burley, S.K, Buchanan, S.G. | 登録日 | 2004-08-30 | 公開日 | 2004-11-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase. J.Biol.Chem., 279, 2004
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1QWG
| Crystal structure of Methanococcus jannaschii phosphosulfolactate synthase | 分子名称: | (2R)-phospho-3-sulfolactate synthase, SULFATE ION | 著者 | Wise, E.L, Graham, D.E, White, R.H, Rayment, I. | 登録日 | 2003-09-02 | 公開日 | 2003-12-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The structural determination of phosphosulfolactate synthase from Methanococcus jannaschii at 1.7-A resolution: an enolase that is not an enolase J.Biol.Chem., 278, 2003
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1Q6A
| Solution Structure of the C-terminal Domain of Thermosynechococcus elongatus KaiA (ThKaiA180C); Averaged Minimized Structure | 分子名称: | Circadian clock protein KaiA homolog | 著者 | Vakonakis, I, Sun, J, Holzenburg, A, Golden, S.S, LiWang, A.C. | 登録日 | 2003-08-13 | 公開日 | 2003-08-19 | 最終更新日 | 2011-07-13 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structure of the KaiC-interacting C-terminal domain of KaiA, a circadian clock protein: Implications for KaiA-KaiC interaction Proc.Natl.Acad.Sci.USA, 101, 2004
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1LZG
| DISSECTION OF PROTEIN-CARBOHYDRATE INTERACTIONS IN MUTANT HEN EGG-WHITE LYSOZYME COMPLEXES AND THEIR HYDROLYTIC ACTIVITY | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEN EGG WHITE LYSOZYME | 著者 | Maenaka, K, Matsushima, M, Song, H, Watanabe, K, Kumagai, I. | 登録日 | 1995-02-10 | 公開日 | 1995-05-08 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Dissection of protein-carbohydrate interactions in mutant hen egg-white lysozyme complexes and their hydrolytic activity. J.Mol.Biol., 247, 1995
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4JAS
| Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E and RR468mutant V13P, L14I, I17M and N21V) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histidine kinase, MAGNESIUM ION, ... | 著者 | Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. | 登録日 | 2013-02-19 | 公開日 | 2013-09-04 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling Structure, 21, 2013
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1QPU
| SOLUTION STRUCTURE OF OXIDIZED ESCHERICHIA COLI CYTOCHROME B562 | 分子名称: | CYTOCHROME B562, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Arnesano, F, Banci, L, Bertini, I, Faraone-Mennella, J, Rosato, A, Barker, P.D, Fersht, A.R. | 登録日 | 1999-05-30 | 公開日 | 1999-06-02 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of oxidized Escherichia coli cytochrome b562. Biochemistry, 38, 1999
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1LVF
| syntaxin 6 | 分子名称: | syntaxin 6 | 著者 | Misura, K.M.S, Bock, J.B, Gonzalez, L.C, Scheller, R.H, Weis, W.I. | 登録日 | 2002-05-28 | 公開日 | 2002-07-17 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog. Proc.Natl.Acad.Sci.USA, 99, 2002
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1PLX
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