1XA5

Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid

Summary for 1XA5
DescriptorCalmodulin, CALCIUM ION, 3"-(BETA-CHLOROETHYL)-2",4"-DIOXO-3, 5"-SPIRO-OXAZOLIDINO-4-DEACETOXY-VINBLASTINE, ... (4 entities in total)
Functional Keywordscalmodulin, vinca alkaloid, kar-2, drug binding, metal binding protein
Biological sourceBos taurus (cattle)
Total number of polymer chains1
Total formula weight17708.08
Authors
Horvath, I.,Harmat, V.,Hlavanda, E.,Naray-Szabo, G.,Ovadi, J. (deposition date: 2004-08-25, release date: 2004-12-21, Last modification date: 2018-10-03)
Primary citationHarmat, V.,Hlavanda, E.,Horvath, I.,Nagy, A.,Naray-Szabo, G.,Nyitrai, L.,Ovadi, J.,Palfi, V.,Perczel, A.
The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug
J.Biol.Chem., 280:8266-8274, 2005
PubMed: 15596444
DOI: 110.1074/jbc.M410353200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.12 Å)
Structure validation
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178747

PDB entries from 2021-06-09