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1XA5

Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid

Functional Information from GO Data
ChainGOidnamespacecontents
A0000922cellular_componentspindle pole
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0019904molecular_functionprotein domain specific binding
A0030234molecular_functionenzyme regulator activity
A0032991cellular_componentprotein-containing complex
A0046872molecular_functionmetal ion binding
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 149
ChainResidue
AASP20
AASP22
AASP24
ATHR26
AGLU31
AHOH188

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 151
ChainResidue
ATYR99
AGLU104
AHOH196
AASP93
AASP95
AASN97

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 152
ChainResidue
AASP129
AASP131
AASP133
AGLN135
AGLU140
AHOH168

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 150
ChainResidue
AASP56
AASP58
AASN60
ATHR62
AGLU67
AHOH159

site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE KAR A 153
ChainResidue
AGLN3
ALEU18
APHE19
ALEU39
APHE68
AMET72
AILE85
AMET109
AMET144
AMET145
AALA147
ALYS148
AHOH155
AHOH180

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
AASP20-LEU32
AASP56-PHE68
AASP93-LEU105
AASP129-PHE141

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
AGLY23
AGLY25
AILE27
ALEU32
ALYS21
AALA57
AGLY59
AGLY61
AILE63
APHE68
ALYS94
AGLY96
AGLY98
AILE100
ALEU105
AILE130
AGLY132
AGLY134
AVAL136
APHE141

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7356670
ChainResidueDetails
AASP2

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
AASP22

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29
ChainResidueDetails
AGLU45

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
AALA102
AGLU82

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
AASP95

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
AGLU139
AILE100

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
AASN111

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
ALEU116

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:9716384
ChainResidueDetails
AASP22

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PDB entries from 2024-04-17

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