1X96

Crystal structure of Aldose Reductase with citrates bound in the active site

Summary for 1X96

Related1PWM 1X97 1X98
Descriptoraldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ... (4 entities in total)
Functional Keywordseight strandard alpha/beta barrel, active site, the c-terminal end of the barrel, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P15121
Total number of polymer chains1
Total molecular weight37025.99
Authors
El-Kabbani, O.,Darmanin, C.,Oka, M.,Schulze-Briese, C.,Tomizaki, T.,Hazemann, I.,Mitschler, A.,Podjarny, A. (deposition date: 2004-08-19, release date: 2004-09-07, Last modification date: 2011-07-13)
Primary citation
El-Kabbani, O.,Darmanin, C.,Oka, M.,Schulze-Briese, C.,Tomizaki, T.,Hazemann, I.,Mitschler, A.,Podjarny, A.
High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
J.Med.Chem., 47:4530-4537, 2004
PubMed: 15317464 (PDB entries with the same primary citation)
DOI: 10.1021/jm0497794
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1631303.6%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report