1QDS

SUPERSTABLE E65Q MUTANT OF LEISHMANIA MEXICANA TRIOSEPHOSPHATE ISOMERASE (TIM)

Summary for 1QDS

• Entry DOI: 10.2210/pdb1qds/pdb
• Related: 1AMK
• Descriptor: TRIOSEPHOSPHATE ISOMERASE, 2-PHOSPHOGLYCOLIC ACID (3 entities in total)
• Functional Keywords: tim, leishmania, stability, mutagenesis, pka, isomerase
• Biological source: Leishmania mexicana
• Cellular location: Cytoplasm: P48499
• Total number of polymer chains: 1
• Total formula weight: 27364.27

Authors

Lambeir, A.M.,Backmann, J.,Ruiz-Sanz, J.,Filimonov, V.,Nielsen, J.E.,Vriend, G.,Kursula, I.,Norledge, B.V.,Wierenga, R.K. (deposition date: 1999-07-10, release date: 2000-12-13, Last modification date: 2024-02-14)

• Primary citation: Lambeir, A.M.,Backmann, J.,Ruiz-Sanz, J.,Filimonov, V.,Nielsen, J.E.,Kursula, I.,Norledge, B.V.,Wierenga, R.K.; The ionization of a buried glutamic acid is thermodynamically linked to the stability of Leishmania mexicana triose phosphate isomerase.; Eur.J.Biochem., 267:2516-2524, 2000; PubMed: 10785370; DOI: 10.1046/j.1432-1327.2000.01254.x

Experimental method

X-RAY DIFFRACTION (2 Å)