2HEW
| |
2HFG
| Crystal structure of hBR3 bound to CB3s-Fab | 分子名称: | CB3s Fab heavy chain, CB3s Fab light chain (kappa), Tumor necrosis factor receptor superfamily member 13C | 著者 | Hymowitz, S.G. | 登録日 | 2006-06-23 | 公開日 | 2006-11-07 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. Blood, 108, 2006
|
|
2H9G
| |
2HFF
| Crystal structure of CB2 Fab | 分子名称: | CB2 Fab, heavy chain, light chain | 著者 | Hymowitz, S.G. | 登録日 | 2006-06-23 | 公開日 | 2006-11-07 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. Blood, 108, 2006
|
|
2HEY
| Crystal structure of murine OX40L bound to human OX40 | 分子名称: | SULFATE ION, Tumor necrosis factor ligand superfamily member 4, Tumor necrosis factor receptor superfamily member 4 | 著者 | Hymowitz, S.G. | 登録日 | 2006-06-22 | 公開日 | 2006-08-29 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Crystal Structure of the Costimulatory OX40-OX40L Complex. Structure, 14, 2006
|
|
6XAG
| Apo BRAF dimer bound to 14-3-3 | 分子名称: | 1,2-ETHANEDIOL, 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | 著者 | Liau, N.P.D, Hymowitz, S.G, Sudhamsu, J. | 登録日 | 2020-06-04 | 公開日 | 2020-10-07 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Dimerization Induced by C-Terminal 14-3-3 Binding Is Sufficient for BRAF Kinase Activation. Biochemistry, 59, 2020
|
|
6PPG
| |
2AW2
| Crystal structure of the human BTLA-HVEM complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B and T lymphocyte attenuator, NICKEL (II) ION, ... | 著者 | Compaan, D.M, Gonzalez, L.C, Tom, I, Loyet, K.M, Eaton, D, Hymowitz, S.G. | 登録日 | 2005-08-31 | 公開日 | 2005-09-27 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Attenuating Lymphocyte Activity: the crystal structure of the BTLA-HVEM complex J.Biol.Chem., 280, 2005
|
|
6NYQ
| |
4MNE
| Crystal structure of the BRAF:MEK1 complex | 分子名称: | 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G. | 登録日 | 2013-09-10 | 公開日 | 2014-06-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8483 Å) | 主引用文献 | Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling. Cancer Cell, 26, 2014
|
|
4MNF
| Crystal structure of BRAF-V600E bound to GDC0879 | 分子名称: | 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, CHLORIDE ION, Serine/threonine-protein kinase B-raf | 著者 | Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G. | 登録日 | 2013-09-10 | 公開日 | 2014-06-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.802 Å) | 主引用文献 | Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling. Cancer Cell, 26, 2014
|
|
6G4Y
| Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 1a | 分子名称: | 10-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrolidin-3-yl]ethynyl]-~{N}3-(oxan-4-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide, Mitogen-activated protein kinase kinase kinase 14, SULFATE ION | 著者 | Hole, A.J, Hymowitz, S.G, McEwan, P.A. | 登録日 | 2018-03-28 | 公開日 | 2018-07-04 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase. J. Med. Chem., 61, 2018
|
|
6G4Z
| Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 2f | 分子名称: | 5-fluoranyl-1-[4-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrol-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide, Mitogen-activated protein kinase kinase kinase 14 | 著者 | Leonardo-Silvestre, H, McEwan, P.A, Hymowitz, S.G. | 登録日 | 2018-03-28 | 公開日 | 2018-07-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase. J. Med. Chem., 61, 2018
|
|
6U2H
| BRAF dimer bound to 14-3-3 | 分子名称: | 14-3-3 protein zeta/delta, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Serine/threonine-protein kinase B-raf | 著者 | Liau, N.P.D, Hymowitz, S.G, Sudhamsu, J. | 登録日 | 2019-08-19 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization. Nat.Struct.Mol.Biol., 27, 2020
|
|
5WNL
| |
5WNJ
| |
5WNK
| Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to TG100-115 | 分子名称: | 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol, CHLORIDE ION, Receptor-interacting serine/threonine-protein kinase 4 | 著者 | Huang, C.S, Hymowitz, S.G. | 登録日 | 2017-08-01 | 公開日 | 2018-05-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity. Structure, 26, 2018
|
|
5WNI
| |
7SD1
| |
7SD0
| Cryo-EM structure of the SHOC2:PP1C:MRAS complex | 分子名称: | Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, MANGANESE (II) ION, ... | 著者 | Liau, N.P.D, Johnson, M.C, Hymowitz, S.G, Sudhamsu, J. | 登録日 | 2021-09-29 | 公開日 | 2022-04-20 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis for SHOC2 modulation of RAS signalling. Nature, 609, 2022
|
|
7SZR
| NIK bound to inhibitor G02792917 | 分子名称: | 1-(3-{[(1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2-azabicyclo[3.1.0]hexan-4-yl]ethynyl}phenyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide, Mitogen-activated protein kinase kinase kinase 14, SULFATE ION | 著者 | Liau, N.P.D, Hymowitz, S.G. | 登録日 | 2021-11-29 | 公開日 | 2023-06-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design. Bioorg.Med.Chem.Lett., 89, 2023
|
|
5HID
| BRAF Kinase domain b3aC loop deletion mutant in complex with AZ628 | 分子名称: | 3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide, DI(HYDROXYETHYL)ETHER, Serine/threonine-protein kinase B-raf | 著者 | Whalen, D.M, Foster, S.A, Ozen, A, Wongchenko, M, Yin, J, Schaefer, G, Mayfield, J, Chmielecki, J, Stephens, P, Albacker, L, Yan, Y, Song, K, Hatzivassiliou, G, Eigenbrot, C, Yu, C, Shaw, A.S, Manning, G, Skelton, N.J, Hymowitz, S.G, Malek, S. | 登録日 | 2016-01-11 | 公開日 | 2016-04-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29, 2016
|
|
5HI2
| BRAF Kinase domain b3aC loop deletion mutant in complex with sorafenib | 分子名称: | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, Serine/threonine-protein kinase B-raf | 著者 | Whalen, D.M, Foster, S.A, Ozen, A, Wongchenko, M, Yin, J, Schaefer, G, Mayfield, J, Chmielecki, J, Stephens, P, Albacker, L, Yan, Y, Song, K, Hatzivassiliou, G, Eigenbrot, C, Yu, C, Shaw, A.S, Manning, G, Skelton, N.J, Hymowitz, S.G, Malek, S. | 登録日 | 2016-01-11 | 公開日 | 2016-04-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.512 Å) | 主引用文献 | Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29, 2016
|
|
5HIE
| BRAF Kinase domain b3aC loop deletion mutant in complex with dabrafenib | 分子名称: | Dabrafenib, Serine/threonine-protein kinase B-raf | 著者 | Whalen, D.M, Foster, S.A, Ozen, A, Wongchenko, M, Yin, J, Schaefer, G, Mayfield, J, Chmielecki, J, Stephens, P, Albacker, L, Yan, Y, Song, K, Hatzivassiliou, G, Eigenbrot, C, Yu, C, Shaw, A.S, Manning, G, Skelton, N.J, Hymowitz, S.G, Malek, S. | 登録日 | 2016-01-11 | 公開日 | 2016-04-06 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29, 2016
|
|
3HO3
| |