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PDB: 69 件

2HEW
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BU of 2hew by Molmil
The X-ray crystal structure of murine OX40L
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tumor necrosis factor ligand superfamily member 4
著者Hymowitz, S.G, Compaan, D.M.
登録日2006-06-22
公開日2006-08-29
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献The Crystal Structure of the Costimulatory OX40-OX40L Complex.
Structure, 14, 2006
2HFG
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BU of 2hfg by Molmil
Crystal structure of hBR3 bound to CB3s-Fab
分子名称: CB3s Fab heavy chain, CB3s Fab light chain (kappa), Tumor necrosis factor receptor superfamily member 13C
著者Hymowitz, S.G.
登録日2006-06-23
公開日2006-11-07
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
Blood, 108, 2006
2H9G
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BU of 2h9g by Molmil
Crystal structure of phage derived Fab BdF1 with human Death Receptor 5 (DR5)
分子名称: Fab BdF1, heavy chain, light chain, ...
著者Hymowitz, S.G, Compaan, D.M.
登録日2006-06-09
公開日2006-08-08
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Activation of the Proapoptotic Death Receptor DR5 by Oligomeric Peptide and Antibody Agonists.
J.Mol.Biol., 361, 2006
2HFF
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BU of 2hff by Molmil
Crystal structure of CB2 Fab
分子名称: CB2 Fab, heavy chain, light chain
著者Hymowitz, S.G.
登録日2006-06-23
公開日2006-11-07
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
Blood, 108, 2006
2HEY
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BU of 2hey by Molmil
Crystal structure of murine OX40L bound to human OX40
分子名称: SULFATE ION, Tumor necrosis factor ligand superfamily member 4, Tumor necrosis factor receptor superfamily member 4
著者Hymowitz, S.G.
登録日2006-06-22
公開日2006-08-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Crystal Structure of the Costimulatory OX40-OX40L Complex.
Structure, 14, 2006
6XAG
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BU of 6xag by Molmil
Apo BRAF dimer bound to 14-3-3
分子名称: 1,2-ETHANEDIOL, 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf
著者Liau, N.P.D, Hymowitz, S.G, Sudhamsu, J.
登録日2020-06-04
公開日2020-10-07
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Dimerization Induced by C-Terminal 14-3-3 Binding Is Sufficient for BRAF Kinase Activation.
Biochemistry, 59, 2020
6PPG
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BU of 6ppg by Molmil
Crystal structure of IL17FF bound to Fab fragments of MCAF5352A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Fab MCAF5352A heavy chain, ...
著者Huang, C.S, Yin, J.P, Hymowitz, S.G.
登録日2019-07-06
公開日2019-12-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies.
Mabs, 12
2AW2
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BU of 2aw2 by Molmil
Crystal structure of the human BTLA-HVEM complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B and T lymphocyte attenuator, NICKEL (II) ION, ...
著者Compaan, D.M, Gonzalez, L.C, Tom, I, Loyet, K.M, Eaton, D, Hymowitz, S.G.
登録日2005-08-31
公開日2005-09-27
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Attenuating Lymphocyte Activity: the crystal structure of the BTLA-HVEM complex
J.Biol.Chem., 280, 2005
6NYQ
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Crystal structure of glycosylated lysosomal membrane protein (GLMP) luminal domain bound to a Fab fragment
分子名称: 1H3 Fab heavy chain, 1H3 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Huang, C.S, Boenig, G, Hymowitz, S.G.
登録日2019-02-12
公開日2020-01-22
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献GLMP is essential for bone-marrow hematopoiesis and lysosomal glycolipid metabolism
To Be Published
4MNE
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BU of 4mne by Molmil
Crystal structure of the BRAF:MEK1 complex
分子名称: 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ...
著者Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G.
登録日2013-09-10
公開日2014-06-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8483 Å)
主引用文献Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling.
Cancer Cell, 26, 2014
4MNF
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BU of 4mnf by Molmil
Crystal structure of BRAF-V600E bound to GDC0879
分子名称: 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, CHLORIDE ION, Serine/threonine-protein kinase B-raf
著者Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G.
登録日2013-09-10
公開日2014-06-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.802 Å)
主引用文献Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling.
Cancer Cell, 26, 2014
6G4Y
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BU of 6g4y by Molmil
Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 1a
分子名称: 10-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrolidin-3-yl]ethynyl]-~{N}3-(oxan-4-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide, Mitogen-activated protein kinase kinase kinase 14, SULFATE ION
著者Hole, A.J, Hymowitz, S.G, McEwan, P.A.
登録日2018-03-28
公開日2018-07-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase.
J. Med. Chem., 61, 2018
6G4Z
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BU of 6g4z by Molmil
Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 2f
分子名称: 5-fluoranyl-1-[4-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrol-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide, Mitogen-activated protein kinase kinase kinase 14
著者Leonardo-Silvestre, H, McEwan, P.A, Hymowitz, S.G.
登録日2018-03-28
公開日2018-07-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase.
J. Med. Chem., 61, 2018
6U2H
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BU of 6u2h by Molmil
BRAF dimer bound to 14-3-3
分子名称: 14-3-3 protein zeta/delta, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Serine/threonine-protein kinase B-raf
著者Liau, N.P.D, Hymowitz, S.G, Sudhamsu, J.
登録日2019-08-19
公開日2019-08-28
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization.
Nat.Struct.Mol.Biol., 27, 2020
5WNL
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BU of 5wnl by Molmil
Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to staurosporine
分子名称: CHLORIDE ION, Receptor-interacting serine/threonine-protein kinase 4, STAUROSPORINE
著者Huang, C.S, Hymowitz, S.G.
登録日2017-08-01
公開日2018-05-09
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
Structure, 26, 2018
5WNJ
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BU of 5wnj by Molmil
Crystal structure of murine receptor-interacting protein kinase 4 (Ripk4) D143N in complex with lestaurtinib
分子名称: CHLORIDE ION, Lestaurtinib, Receptor-interacting serine/threonine-protein kinase 4
著者Huang, C.S, Hymowitz, S.G.
登録日2017-08-01
公開日2018-05-09
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
Structure, 26, 2018
5WNK
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BU of 5wnk by Molmil
Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to TG100-115
分子名称: 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol, CHLORIDE ION, Receptor-interacting serine/threonine-protein kinase 4
著者Huang, C.S, Hymowitz, S.G.
登録日2017-08-01
公開日2018-05-09
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
Structure, 26, 2018
5WNI
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Crystal structure of murine receptor-interacting protein kinase 4 (Ripk4) D143N in complex with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
著者Huang, C.S, Hymowitz, S.G.
登録日2017-08-01
公開日2018-05-09
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
Structure, 26, 2018
7SD1
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BU of 7sd1 by Molmil
Crystal structure of SHOC2
分子名称: Leucine-rich repeat protein SHOC-2
著者Liau, N.P.D, Hymowitz, S.G, Sudhamsu, J.
登録日2021-09-29
公開日2022-04-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Structural basis for SHOC2 modulation of RAS signalling.
Nature, 609, 2022
7SD0
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BU of 7sd0 by Molmil
Cryo-EM structure of the SHOC2:PP1C:MRAS complex
分子名称: Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, MANGANESE (II) ION, ...
著者Liau, N.P.D, Johnson, M.C, Hymowitz, S.G, Sudhamsu, J.
登録日2021-09-29
公開日2022-04-20
最終更新日2023-11-29
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献Structural basis for SHOC2 modulation of RAS signalling.
Nature, 609, 2022
7SZR
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NIK bound to inhibitor G02792917
分子名称: 1-(3-{[(1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2-azabicyclo[3.1.0]hexan-4-yl]ethynyl}phenyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide, Mitogen-activated protein kinase kinase kinase 14, SULFATE ION
著者Liau, N.P.D, Hymowitz, S.G.
登録日2021-11-29
公開日2023-06-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
Bioorg.Med.Chem.Lett., 89, 2023
5HID
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BRAF Kinase domain b3aC loop deletion mutant in complex with AZ628
分子名称: 3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide, DI(HYDROXYETHYL)ETHER, Serine/threonine-protein kinase B-raf
著者Whalen, D.M, Foster, S.A, Ozen, A, Wongchenko, M, Yin, J, Schaefer, G, Mayfield, J, Chmielecki, J, Stephens, P, Albacker, L, Yan, Y, Song, K, Hatzivassiliou, G, Eigenbrot, C, Yu, C, Shaw, A.S, Manning, G, Skelton, N.J, Hymowitz, S.G, Malek, S.
登録日2016-01-11
公開日2016-04-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Cancer Cell, 29, 2016
5HI2
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BRAF Kinase domain b3aC loop deletion mutant in complex with sorafenib
分子名称: 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, Serine/threonine-protein kinase B-raf
著者Whalen, D.M, Foster, S.A, Ozen, A, Wongchenko, M, Yin, J, Schaefer, G, Mayfield, J, Chmielecki, J, Stephens, P, Albacker, L, Yan, Y, Song, K, Hatzivassiliou, G, Eigenbrot, C, Yu, C, Shaw, A.S, Manning, G, Skelton, N.J, Hymowitz, S.G, Malek, S.
登録日2016-01-11
公開日2016-04-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.512 Å)
主引用文献Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Cancer Cell, 29, 2016
5HIE
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BRAF Kinase domain b3aC loop deletion mutant in complex with dabrafenib
分子名称: Dabrafenib, Serine/threonine-protein kinase B-raf
著者Whalen, D.M, Foster, S.A, Ozen, A, Wongchenko, M, Yin, J, Schaefer, G, Mayfield, J, Chmielecki, J, Stephens, P, Albacker, L, Yan, Y, Song, K, Hatzivassiliou, G, Eigenbrot, C, Yu, C, Shaw, A.S, Manning, G, Skelton, N.J, Hymowitz, S.G, Malek, S.
登録日2016-01-11
公開日2016-04-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Cancer Cell, 29, 2016
3HO3
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BU of 3ho3 by Molmil
Crystal structure of Hedgehog-interacting protein (HHIP)
分子名称: Hedgehog-interacting protein
著者Bosanac, I, Hymowitz, S.G.
登録日2009-06-01
公開日2009-06-23
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009

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