4MNF
Crystal structure of BRAF-V600E bound to GDC0879
Summary for 4MNF
Entry DOI | 10.2210/pdb4mnf/pdb |
Related | 4MNE |
Descriptor | Serine/threonine-protein kinase B-raf, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | raf, mapk, kinase domain, atp-binding, erk, ras, pak, active conformation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P15056 |
Total number of polymer chains | 2 |
Total formula weight | 75286.02 |
Authors | Sudhamsu, J.,Haling, J.R.,Morales, T.,Brandhuber, B.,Hymowitz, S.G. (deposition date: 2013-09-10, release date: 2014-06-18, Last modification date: 2023-09-20) |
Primary citation | Haling, J.R.,Sudhamsu, J.,Yen, I.,Sideris, S.,Sandoval, W.,Phung, W.,Bravo, B.J.,Giannetti, A.M.,Peck, A.,Masselot, A.,Morales, T.,Smith, D.,Brandhuber, B.J.,Hymowitz, S.G.,Malek, S. Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling. Cancer Cell, 26:402-413, 2014 Cited by PubMed: 25155755DOI: 10.1016/j.ccr.2014.07.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.802 Å) |
Structure validation
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