6U2H
BRAF dimer bound to 14-3-3
Summary for 6U2H
Entry DOI | 10.2210/pdb6u2h/pdb |
Related | 6U2G |
Descriptor | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, ... (4 entities in total) |
Functional Keywords | braf, 14-3-3, kinase, complex, signaling protein, signaling protein-transferase complex, signaling protein/transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 119764.23 |
Authors | Liau, N.P.D.,Hymowitz, S.G.,Sudhamsu, J. (deposition date: 2019-08-19, release date: 2019-08-28, Last modification date: 2023-10-11) |
Primary citation | Liau, N.P.D.,Wendorff, T.J.,Quinn, J.G.,Steffek, M.,Phung, W.,Liu, P.,Tang, J.,Irudayanathan, F.J.,Izadi, S.,Shaw, A.S.,Malek, S.,Hymowitz, S.G.,Sudhamsu, J. Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization. Nat.Struct.Mol.Biol., 27:134-141, 2020 Cited by PubMed: 31988522DOI: 10.1038/s41594-019-0365-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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