7SZR

NIK bound to inhibitor G02792917

Summary for 7SZR

• Entry DOI: 10.2210/pdb7szr/pdb
• Descriptor: Mitogen-activated protein kinase kinase kinase 14, SULFATE ION, 1-(3-{[(1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2-azabicyclo[3.1.0]hexan-4-yl]ethynyl}phenyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide (3 entities in total)
• Functional Keywords: kinase, inhibitor, nf-kb inducing kinase, signaling protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 78954.52

Authors

Liau, N.P.D.,Hymowitz, S.G. (deposition date: 2021-11-29, release date: 2023-06-07, Last modification date: 2023-12-20)

• Primary citation: Crawford, J.J.,Feng, J.,Brightbill, H.D.,Johnson, A.R.,Wright, M.,Kolesnikov, A.,Lee, W.,Castanedo, G.M.,Do, S.,Blaquiere, N.,Staben, S.T.,Chiang, P.C.,Fan, P.W.,Baumgardner, M.,Wong, S.,Godemann, R.,Grabbe, A.,Wiegel, C.,Sujatha-Bhaskar, S.,Hymowitz, S.G.,Liau, N.,Hsu, P.L.,McEwan, P.A.,Ismaili, M.H.A.,Landry, M.L.; Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.; Bioorg.Med.Chem.Lett., 89:129277-129277, 2023; PubMed: 37105490; DOI: 10.1016/j.bmcl.2023.129277

Experimental method

X-RAY DIFFRACTION (2.8 Å)