6XAG

Apo BRAF dimer bound to 14-3-3

Summary for 6XAG

• Entry DOI: 10.2210/pdb6xag/pdb
• Descriptor: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf, 1,2-ETHANEDIOL (3 entities in total)
• Functional Keywords: kinase, signaling protein, signaling protein-transferase complex, signaling protein/transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 119157.55

Authors

Liau, N.P.D.,Hymowitz, S.G.,Sudhamsu, J. (deposition date: 2020-06-04, release date: 2020-10-07, Last modification date: 2023-10-18)

• Primary citation: Liau, N.P.D.,Venkatanarayan, A.,Quinn, J.G.,Phung, W.,Malek, S.,Hymowitz, S.G.,Sudhamsu, J.; Dimerization Induced by C-Terminal 14-3-3 Binding Is Sufficient for BRAF Kinase Activation.; Biochemistry, 59:3982-3992, 2020; PubMed: 32970425; DOI: 10.1021/acs.biochem.0c00517

Experimental method

X-RAY DIFFRACTION (3.3 Å)