5HI2

BRAF Kinase domain b3aC loop deletion mutant in complex with sorafenib

Summary for 5HI2

• Entry DOI: 10.2210/pdb5hi2/pdb
• Related: 5HID 5HIE
• Descriptor: Serine/threonine-protein kinase B-raf, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE (3 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P15056
• Total number of polymer chains: 1
• Total formula weight: 32823.89

Authors

Whalen, D.M.,Foster, S.A.,Ozen, A.,Wongchenko, M.,Yin, J.,Schaefer, G.,Mayfield, J.,Chmielecki, J.,Stephens, P.,Albacker, L.,Yan, Y.,Song, K.,Hatzivassiliou, G.,Eigenbrot, C.,Yu, C.,Shaw, A.S.,Manning, G.,Skelton, N.J.,Hymowitz, S.G.,Malek, S. (deposition date: 2016-01-11, release date: 2016-04-06, Last modification date: 2023-09-27)

• Primary citation: Foster, S.A.,Whalen, D.M.,Ozen, A.,Wongchenko, M.J.,Yin, J.,Yen, I.,Schaefer, G.,Mayfield, J.D.,Chmielecki, J.,Stephens, P.J.,Albacker, L.A.,Yan, Y.,Song, K.,Hatzivassiliou, G.,Eigenbrot, C.,Yu, C.,Shaw, A.S.,Manning, G.,Skelton, N.J.,Hymowitz, S.G.,Malek, S.; Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.; Cancer Cell, 29:477-493, 2016; PubMed: 26996308; DOI: 10.1016/j.ccell.2016.02.010

Experimental method

X-RAY DIFFRACTION (2.512 Å)