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PDB: 46 件

6D42
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Crystal structure of the KCa3.1 C-terminal four-helix bundle (with copper)
分子名称: COPPER (II) ION, Intermediate conductance calcium-activated potassium channel protein 4
著者Hubbard, S.R, Ji, T.
登録日2018-04-17
公開日2018-07-11
最終更新日2019-12-18
実験手法X-RAY DIFFRACTION (1.75013649 Å)
主引用文献Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1.
PLoS ONE, 13, 2018
7TEU
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Crystal structure of JAK2 JH1 with type II inhibitor YLIU-04-105-1
分子名称: 3-{(4S)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-N-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide, GLYCEROL, Tyrosine-protein kinase JAK2
著者Hubbard, S.R.
登録日2022-01-05
公開日2023-06-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation.
Cell Chem Biol, 30, 2023
1IR3
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PHOSPHORYLATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG
分子名称: INSULIN RECEPTOR, MAGNESIUM ION, PEPTIDE SUBSTRATE, ...
著者Hubbard, S.R.
登録日1997-09-22
公開日1998-01-07
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog.
EMBO J., 16, 1997
8DWN
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BU of 8dwn by Molmil
Crystal structure of bis-phosphorylated insulin receptor kinase domain
分子名称: Insulin receptor subunit beta
著者Hubbard, S.R.
登録日2022-08-01
公開日2023-08-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of bis-phosphorylated insulin receptor kinase domain
To Be Published
3HK0
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BU of 3hk0 by Molmil
Crystal Structure of the RA and PH Domains of Grb10
分子名称: Growth factor receptor-bound protein 10, THIOCYANATE ION
著者Hubbard, S.R, Depetris, R.S, Wu, J.
登録日2009-05-22
公開日2009-08-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
Nat.Struct.Mol.Biol., 16, 2009
3RGK
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BU of 3rgk by Molmil
Crystal Structure of Human Myoglobin Mutant K45R
分子名称: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者Hubbard, S.R.
登録日2011-04-08
公開日2011-04-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献X-ray crystal structure of a recombinant human myoglobin mutant at 2.8 A resolution
J.Mol.Biol., 20, 1990
4XLV
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Crystal structure of the activated insulin receptor tyrosine kinase dimer
分子名称: Insulin receptor, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
著者Hubbard, S.R, Li, S.
登録日2015-01-13
公開日2015-03-25
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.
Nat Commun, 6, 2015
1IRK
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BU of 1irk by Molmil
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR
分子名称: ETHYL MERCURY ION, INSULIN RECEPTOR TYROSINE KINASE DOMAIN
著者Hubbard, S.R, Wei, L, Ellis, L, Hendrickson, W.A.
登録日1995-01-02
公開日1995-02-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the tyrosine kinase domain of the human insulin receptor.
Nature, 372, 1994
3D94
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Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP
分子名称: 3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine, CALCIUM ION, Insulin-like growth factor 1 receptor beta chain
著者Wu, J, Li, W, Miller, W.T, Hubbard, S.R.
登録日2008-05-26
公開日2008-07-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor
Embo J., 27, 2008
4K81
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Crystal structure of the Grb14 RA and PH domains in complex with GTP-loaded H-Ras
分子名称: GLYCEROL, GTPase HRas, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Qamra, R, Hubbard, S.R.
登録日2013-04-17
公開日2013-09-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for the interaction of the adaptor protein grb14 with activated ras.
Plos One, 8, 2013
3ML4
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Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region
分子名称: Muscle, skeletal receptor tyrosine-protein kinase, Protein Dok-7
著者Bergamin, E, Hubbard, S.R.
登録日2010-04-16
公開日2010-07-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Cytoplasmic Adaptor Protein Dok7 Activates the Receptor Tyrosine Kinase MuSK via Dimerization.
Mol.Cell, 39, 2010
8EX1
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Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with Reversine
分子名称: GLYCEROL, N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine, Tyrosine-protein kinase JAK2
著者Sampathkumar, P, Hubbard, S.R.
登録日2022-10-24
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Pharmaceuticals, 16, 2023
8EX0
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Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with CDK2-IV
分子名称: 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide, Tyrosine-protein kinase JAK2
著者Sampathkumar, P, Hubbard, S.R.
登録日2022-10-24
公開日2023-02-01
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Pharmaceuticals, 16, 2023
8EX2
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Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with HTSA3
分子名称: 3,5-diphenyl-2-(trifluoromethyl)-6~{H}-pyrazolo[1,5-a]pyrimidin-7-one, GLYCEROL, Tyrosine-protein kinase JAK2
著者Sampathkumar, P, Hubbard, S.R.
登録日2022-10-24
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Pharmaceuticals, 16, 2023
3HKL
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BU of 3hkl by Molmil
Crystal Structure of the Frizzled-like Cysteine-rich Domain of MuSK
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Muscle, skeletal receptor tyrosine protein kinase
著者Stiegler, A.L, Hubbard, S.R.
登録日2009-05-24
公開日2009-08-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK.
J.Mol.Biol., 393, 2009
3TCA
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BU of 3tca by Molmil
Crystal structure of the Ras-associating and pleckstrin-homology domains of RIAM
分子名称: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
著者Wu, J, Hubbard, S.R.
登録日2011-08-08
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector.
J.Cell Biol., 199, 2012
1CVS
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BU of 1cvs by Molmil
CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX
分子名称: FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION
著者Plotnikov, A.N, Schlessinger, J, Hubbard, S.R, Mohammadi, M.
登録日1999-08-24
公開日2000-01-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for FGF receptor dimerization and activation.
Cell(Cambridge,Mass.), 98, 1999
1DCQ
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BU of 1dcq by Molmil
CRYSTAL STRUCTURE OF THE ARF-GAP DOMAIN AND ANKYRIN REPEATS OF PAPBETA.
分子名称: PYK2-ASSOCIATED PROTEIN BETA, ZINC ION
著者Mandiyan, V, Andreev, J, Schlessinger, J, Hubbard, S.R.
登録日1999-11-05
公開日1999-12-22
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta.
EMBO J., 18, 1999
1AGW
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR
分子名称: 3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE, FGF RECEPTOR 1
著者Mohammadi, M, Schlessinger, J, Hubbard, S.R.
登録日1997-03-25
公開日1998-03-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
1K3A
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Structure of the Insulin-like Growth Factor 1 Receptor Kinase
分子名称: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, insulin receptor substrate 1, insulin-like growth factor 1 receptor
著者Favelyukis, S, Till, J.H, Hubbard, S.R, Miller, W.T.
登録日2001-10-02
公開日2001-11-28
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.
Nat.Struct.Biol., 8, 2001
1LUF
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Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation
分子名称: muscle-specific tyrosine kinase receptor musk
著者Till, J.H, Becerra, M, Watty, A, Lu, Y, Ma, Y, Neubert, T.A, Burden, S.J, Hubbard, S.R.
登録日2002-05-22
公開日2002-09-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.
Structure, 10, 2002
1YVH
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Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide
分子名称: 13-mer fragment of SH2 and PH domain-containing adapter protein APS, CBL E3 ubiquitin protein ligase, MAGNESIUM ION
著者Hu, J, Hubbard, S.R.
登録日2005-02-15
公開日2005-03-08
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins
J.Biol.Chem., 280, 2005
2B4S
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Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase
分子名称: Insulin receptor, SULFATE ION, Tyrosine-protein phosphatase, ...
著者Li, S, Depetris, R.S, Barford, D, Chernoff, J, Hubbard, S.R.
登録日2005-09-26
公開日2005-11-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of a Complex between Protein Tyrosine Phosphatase 1B and the Insulin Receptor Tyrosine Kinase.
Structure, 13, 2005
2AUG
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Crystal structure of the Grb14 SH2 domain
分子名称: Growth factor receptor-bound protein 14
著者Depetris, R.S, Hu, J, Gimpelevich, I, Holt, L.J, Daly, R.J, Hubbard, S.R.
登録日2005-08-27
公開日2005-11-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for inhibition of the insulin receptor by the adaptor protein grb14.
Mol.Cell, 20, 2005
2AUH
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Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase
分子名称: CALCIUM ION, Growth factor receptor-bound protein 14, Insulin receptor
著者Depetris, R.S, Hu, J, Gimpelevich, I, Holt, L.J, Daly, R.J, Hubbard, S.R.
登録日2005-08-27
公開日2005-11-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for inhibition of the insulin receptor by the adaptor protein grb14.
Mol.Cell, 20, 2005

 

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