6D42
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7TEU
| Crystal structure of JAK2 JH1 with type II inhibitor YLIU-04-105-1 | 分子名称: | 3-{(4S)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-N-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide, GLYCEROL, Tyrosine-protein kinase JAK2 | 著者 | Hubbard, S.R. | 登録日 | 2022-01-05 | 公開日 | 2023-06-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation. Cell Chem Biol, 30, 2023
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1IR3
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8DWN
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3HK0
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3RGK
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4XLV
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1IRK
| CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR | 分子名称: | ETHYL MERCURY ION, INSULIN RECEPTOR TYROSINE KINASE DOMAIN | 著者 | Hubbard, S.R, Wei, L, Ellis, L, Hendrickson, W.A. | 登録日 | 1995-01-02 | 公開日 | 1995-02-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature, 372, 1994
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3D94
| Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP | 分子名称: | 3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine, CALCIUM ION, Insulin-like growth factor 1 receptor beta chain | 著者 | Wu, J, Li, W, Miller, W.T, Hubbard, S.R. | 登録日 | 2008-05-26 | 公開日 | 2008-07-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor Embo J., 27, 2008
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4K81
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3ML4
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8EX1
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8EX0
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8EX2
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3HKL
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3TCA
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1CVS
| CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX | 分子名称: | FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION | 著者 | Plotnikov, A.N, Schlessinger, J, Hubbard, S.R, Mohammadi, M. | 登録日 | 1999-08-24 | 公開日 | 2000-01-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for FGF receptor dimerization and activation. Cell(Cambridge,Mass.), 98, 1999
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1DCQ
| CRYSTAL STRUCTURE OF THE ARF-GAP DOMAIN AND ANKYRIN REPEATS OF PAPBETA. | 分子名称: | PYK2-ASSOCIATED PROTEIN BETA, ZINC ION | 著者 | Mandiyan, V, Andreev, J, Schlessinger, J, Hubbard, S.R. | 登録日 | 1999-11-05 | 公開日 | 1999-12-22 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta. EMBO J., 18, 1999
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1AGW
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1K3A
| Structure of the Insulin-like Growth Factor 1 Receptor Kinase | 分子名称: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, insulin receptor substrate 1, insulin-like growth factor 1 receptor | 著者 | Favelyukis, S, Till, J.H, Hubbard, S.R, Miller, W.T. | 登録日 | 2001-10-02 | 公開日 | 2001-11-28 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat.Struct.Biol., 8, 2001
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1LUF
| Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation | 分子名称: | muscle-specific tyrosine kinase receptor musk | 著者 | Till, J.H, Becerra, M, Watty, A, Lu, Y, Ma, Y, Neubert, T.A, Burden, S.J, Hubbard, S.R. | 登録日 | 2002-05-22 | 公開日 | 2002-09-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation. Structure, 10, 2002
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1YVH
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2B4S
| Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase | 分子名称: | Insulin receptor, SULFATE ION, Tyrosine-protein phosphatase, ... | 著者 | Li, S, Depetris, R.S, Barford, D, Chernoff, J, Hubbard, S.R. | 登録日 | 2005-09-26 | 公開日 | 2005-11-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of a Complex between Protein Tyrosine Phosphatase 1B and the Insulin Receptor Tyrosine Kinase. Structure, 13, 2005
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2AUG
| Crystal structure of the Grb14 SH2 domain | 分子名称: | Growth factor receptor-bound protein 14 | 著者 | Depetris, R.S, Hu, J, Gimpelevich, I, Holt, L.J, Daly, R.J, Hubbard, S.R. | 登録日 | 2005-08-27 | 公開日 | 2005-11-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for inhibition of the insulin receptor by the adaptor protein grb14. Mol.Cell, 20, 2005
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2AUH
| Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase | 分子名称: | CALCIUM ION, Growth factor receptor-bound protein 14, Insulin receptor | 著者 | Depetris, R.S, Hu, J, Gimpelevich, I, Holt, L.J, Daly, R.J, Hubbard, S.R. | 登録日 | 2005-08-27 | 公開日 | 2005-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for inhibition of the insulin receptor by the adaptor protein grb14. Mol.Cell, 20, 2005
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