3EZV
 
 | | CDK-2 with indazole inhibitor 9 bound at its active site | | Descriptor: | 4-{3-[7-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline, Cell division protein kinase 2 | | Authors: | Kiefer, J.R, Day, J.E, Caspers, N.L, Mathis, K.J, Kretzmer, K.K, Weinberg, R.A, Reitz, B.A, Stegeman, R.A, Trujillo, J.I, Huang, W, Thorarensen, A, Xing, L, Wrightstone, A, Christine, L, Compton, R, Li, X. | | Deposit date: | 2008-10-23 | | Release date: | 2009-02-03 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor
Bioorg.Med.Chem.Lett., 19, 2009
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1D2L
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3EZR
 | | CDK-2 with indazole inhibitor 17 bound at its active site | | Descriptor: | 3-methoxy-4-{3-[4-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline, Cell division protein kinase 2 | | Authors: | Kiefer, J.R, Day, J.E, Caspers, N.L, Mathis, K.J, Kretzmer, K.K, Weinberg, R.A, Reitz, B.A, Stegeman, R.A, Trujillo, J.I, Huang, W, Thorarensen, A, Xing, L, Wrightstone, A, Christine, L, Compton, R, Li, X. | | Deposit date: | 2008-10-23 | | Release date: | 2009-02-03 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor
Bioorg.Med.Chem.Lett., 19, 2009
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3F5X
 | | CDK-2-Cyclin complex with indazole inhibitor 9 bound at its active site | | Descriptor: | 4-{3-[7-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline, Cell division protein kinase 2, Cyclin-A2, ... | | Authors: | Kiefer, J.R, Day, J.E, Caspers, N.L, Mathis, K.J, Kretzmer, K.K, Weinberg, R.A, Reitz, B.A, Stegeman, R.A, Trujillo, J.I, Huang, W, Thorarensen, A, Xing, L, Wrightstone, A, Christine, L, Compton, R, Li, X. | | Deposit date: | 2008-11-04 | | Release date: | 2009-02-03 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor.
Bioorg.Med.Chem.Lett., 19, 2009
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1ONR
 | | STRUCTURE OF TRANSALDOLASE B | | Descriptor: | TRANSALDOLASE B | | Authors: | Jia, J, Huang, W, Lindqvist, Y, Schneider, G. | | Deposit date: | 1996-08-13 | | Release date: | 1997-03-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Crystal structure of transaldolase B from Escherichia coli suggests a circular permutation of the alpha/beta barrel within the class I aldolase family.
Structure, 4, 1996
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3OY3
 | | Crystal structure of ABL T315I mutant kinase domain bound with a DFG-out inhibitor AP24589 | | Descriptor: | 5-[(5-{[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]carbamoyl}-2-methylphenyl)ethynyl]-1-methyl-1H-imidazole-2-carboxamide, Tyrosine-protein kinase ABL1 | | Authors: | Zhou, T, Commodore, L, Huang, W.S, Wang, Y, Thomas, M, Keats, J, Xu, Q, Rivera, V, Shakespeare, W.C, Clackson, T, Dalgarno, D.C, Zhu, X. | | Deposit date: | 2010-09-22 | | Release date: | 2010-12-15 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance.
Chem.Biol.Drug Des., 77, 2011
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3OXZ
 | | Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534 | | Descriptor: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Tyrosine-protein kinase ABL1 | | Authors: | Zhou, T, Huang, W.S, Wang, Y, Thomas, M, Keats, J, Xu, Q, Rivera, V, Shakespeare, W.C, Clackson, T, Dalgarno, D.C, Zhu, X. | | Deposit date: | 2010-09-22 | | Release date: | 2010-12-15 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance.
Chem.Biol.Drug Des., 77, 2011
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7C2E
 | | GLP-1R-Gs complex structure with a small molecule full agonist | | Descriptor: | 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Ma, H, Yuan, D.P, Huang, W, Wenge, Z, Xu, E. | | Deposit date: | 2020-05-07 | | Release date: | 2020-08-26 | | Last modified: | 2020-12-16 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structural insights into the activation of GLP-1R by a small molecule agonist.
Cell Res., 30, 2020
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4IU9
 | | Crystal structure of a membrane transporter | | Descriptor: | Nitrite extrusion protein 2 | | Authors: | Yan, H, Huang, W, Yan, C, Gong, X, Jiang, S, Zhao, Y, Wang, J, Shi, Y. | | Deposit date: | 2013-01-20 | | Release date: | 2013-04-17 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.005 Å) | | Cite: | Structure and mechanism of a nitrate transporter.
Cell Rep, 3, 2013
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4IU8
 | | Crystal structure of a membrane transporter (selenomethionine derivative) | | Descriptor: | NITRATE ION, Nitrite extrusion protein 2 | | Authors: | Yan, H, Huang, W, Yan, C, Gong, X, Jiang, S, Zhao, Y, Wang, J, Shi, Y. | | Deposit date: | 2013-01-20 | | Release date: | 2013-04-17 | | Method: | X-RAY DIFFRACTION (3.11 Å) | | Cite: | Structure and mechanism of a nitrate transporter.
Cell Rep, 3, 2013
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7T2H
 | | CryoEM structure of mu-opioid receptor - Gi protein complex bound to lofentanil (LFT) | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Seven, A.B, Qu, Q, Huang, W, Robertson, M.J, Kobilka, B.K, Skiniotis, G. | | Deposit date: | 2021-12-04 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Insights into distinct signaling profiles of the mu OR activated by diverse agonists.
Nat.Chem.Biol., 2022
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7TUY
 | | Cryo-EM structure of GSK682753A-bound EBI2/GPR183 | | Descriptor: | 8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, G-protein coupled receptor 183,Soluble cytochrome b562 fusion, anti-BRIL Fab Heavy chain, ... | | Authors: | Chen, H, Huang, W, Li, X. | | Deposit date: | 2022-02-03 | | Release date: | 2022-04-13 | | Last modified: | 2022-07-20 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.
Structure, 30, 2022
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1AFR
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8FCK
 | | Structure of the vertebrate augmin complex | | Descriptor: | HAUS augmin like complex subunit 2 L homeolog, Green fluorescent protein chimera, HAUS augmin like complex subunit 4 L homeolog, ... | | Authors: | Travis, S.M, Huang, W, Zhang, R, Petry, S. | | Deposit date: | 2022-12-01 | | Release date: | 2023-04-19 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (6.88 Å) | | Cite: | Integrated model of the vertebrate augmin complex.
Nat Commun, 14, 2023
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8YRF
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8INV
 | | Crystal structure of UGT74AN3-UDP-BUF | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Glycosyltransferase, URIDINE-5'-DIPHOSPHATE, ... | | Authors: | Long, F, Huang, W. | | Deposit date: | 2023-03-10 | | Release date: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3
Acs Catalysis, 14, 2024
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8INA
 | | Crystal structure of UGT74AN3-UDP | | Descriptor: | GLYCEROL, Glycosyltransferase, URIDINE-5'-DIPHOSPHATE | | Authors: | Long, F, Huang, W. | | Deposit date: | 2023-03-09 | | Release date: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3
Acs Catalysis, 14, 2024
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8INO
 | | Crystal structure of UGT74AN3 in complex UDP and PER | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-[(3S,5S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3,5,14-tris(oxidanyl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one, Glycosyltransferase, ... | | Authors: | Long, F, Huang, W. | | Deposit date: | 2023-03-10 | | Release date: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3
Acs Catalysis, 14, 2024
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8K6Z
 | | NMR structure of human leptin | | Descriptor: | Leptin | | Authors: | Fan, X, Qin, R, Yuan, W, Fan, J, Huang, W, Lin, Z. | | Deposit date: | 2023-07-26 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The solution structure of human leptin reveals a conformational plasticity important for receptor recognition.
Structure, 32, 2024
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6JM5
 | | Crystal structure of TBC1D23 C terminal domain | | Descriptor: | SODIUM ION, TBC1 domain family member 23 | | Authors: | Sun, Q, Huang, W. | | Deposit date: | 2019-03-07 | | Release date: | 2019-10-16 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH.
Proc.Natl.Acad.Sci.USA, 116, 2019
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2K3N
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2K3O
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2K53
 | | NMR solution structure of A3DK08 protein from Clostridium thermocellum: Northeast Structural Genomics Consortium Target CmR9 | | Descriptor: | A3DK08 Protein | | Authors: | Swapna, G.V.T, Huang, W, Jiang, M, Foote, E.L, Xiao, R, Nair, R, Everett, J, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-06-24 | | Release date: | 2008-08-19 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | NMR Solution Structure of A3DK08 protein from Clostridium thermocellum: Northeast Structural Genomics Consortium Target CmR9
To be Published
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8IR4
 | | Crystal structure of the SLF1 BRCT domain in complex with a Rad18 peptide containing pS442 | | Descriptor: | CHLORIDE ION, ISOPROPYL ALCOHOL, MAGNESIUM ION, ... | | Authors: | Xiang, S, Huang, W, Qiu, F. | | Deposit date: | 2023-03-17 | | Release date: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Structural insights into Rad18 targeting by the SLF1 BRCT domains.
J.Biol.Chem., 299, 2023
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8IR2
 | | Crystal structure of the SLF1 BRCT domain in complex with a Rad18 peptide containing pS442 and pS444 | | Descriptor: | CHLORIDE ION, ISOPROPYL ALCOHOL, MAGNESIUM ION, ... | | Authors: | Xiang, S, Huang, W, Qiu, F. | | Deposit date: | 2023-03-17 | | Release date: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural insights into Rad18 targeting by the SLF1 BRCT domains.
J.Biol.Chem., 299, 2023
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