1ONR

STRUCTURE OF TRANSALDOLASE B

Summary for 1ONR

• Entry DOI: 10.2210/pdb1onr/pdb
• Descriptor: TRANSALDOLASE B (2 entities in total)
• Functional Keywords: transferase, pentose shunt, multigene family
• Biological source: Escherichia coli
• Cellular location: Cytoplasm (Probable): P0A870
• Total number of polymer chains: 2
• Total formula weight: 70255.93

Authors

Jia, J.,Huang, W.,Lindqvist, Y.,Schneider, G. (deposition date: 1996-08-13, release date: 1997-03-12, Last modification date: 2024-02-14)

Primary citation

Jia, J.,Huang, W.,Schorken, U.,Sahm, H.,Sprenger, G.A.,Lindqvist, Y.,Schneider, G.
Crystal structure of transaldolase B from Escherichia coli suggests a circular permutation of the alpha/beta barrel within the class I aldolase family.
Structure, 4:715-724, 1996

PubMed Abstract: Transaldolase is one of the enzymes in the non-oxidative branch of the pentose phosphate pathway. It transfers a C3 ketol fragment from a ketose donor to an aldose acceptor. Transaldolase, together with transketolase, creates a reversible link between the pentose phosphate pathway and glycolysis. The enzyme is of considerable interest as a catalyst in stereospecific organic synthesis and the aim of this work was to reveal the molecular architecture of transaldolase and provide insights into the structural basis of the enzymatic mechanism.

PubMed: 8805555
DOI: 10.1016/S0969-2126(96)00077-9

Experimental method

X-RAY DIFFRACTION (1.87 Å)