1BFT
 
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1BFS
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1Y8X
 | | Structural basis for recruitment of Ubc12 by an E2-binding domain in NEDD8's E1 | | Descriptor: | Ubiquitin-activating enzyme E1C, Ubiquitin-conjugating enzyme E2 M | | Authors: | Huang, D.T, Paydar, A, Zhuang, M, Waddell, M.B, Holton, J.M, Schulman, B.A. | | Deposit date: | 2004-12-13 | | Release date: | 2005-02-08 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
Mol.Cell, 17, 2005
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2NVU
 | | Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein activation complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Maltose binding protein/NEDD8-activating enzyme E1 catalytic subunit chimera, ... | | Authors: | Huang, D.T, Hunt, H.W, Zhuang, M, Ohi, M.D, Holton, J.M, Schulman, B.A. | | Deposit date: | 2006-11-13 | | Release date: | 2007-01-30 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
Nature, 445, 2007
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1OOA
 | | CRYSTAL STRUCTURE OF NF-kB(p50)2 COMPLEXED TO A HIGH-AFFINITY RNA APTAMER | | Descriptor: | Nuclear factor NF-kappa-B p105 subunit, RNA aptamer | | Authors: | Huang, D.B, Vu, D, Cassiday, L.A, Zimmerman, J.M, Maher III, L.J, Ghosh, G. | | Deposit date: | 2003-03-03 | | Release date: | 2003-07-22 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer.
Proc.Natl.Acad.Sci.USA, 100, 2003
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1GJI
 | | Crystal structure of c-Rel bound to DNA | | Descriptor: | C-REL PROTO-ONCOGENE PROTEIN, IL-2 CD28RE DNA | | Authors: | Huang, D.B, Chen, Y.Q, Ruetsche, M, Phelps, C.B, Ghosh, G. | | Deposit date: | 2001-05-30 | | Release date: | 2002-05-30 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2.
Structure, 9, 2001
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5J3X
 | | Structure of c-CBL Y371F | | Descriptor: | CALCIUM ION, E3 ubiquitin-protein ligase CBL, ZINC ION | | Authors: | Huang, D.T, Buetow, L, Dou, H. | | Deposit date: | 2016-03-31 | | Release date: | 2016-09-21 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.822 Å) | | Cite: | Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.
Bmc Biol., 14, 2016
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1TT5
 | | Structure of APPBP1-UBA3-Ubc12N26: a unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 | | Descriptor: | Ubiquitin-conjugating enzyme E2 M, ZINC ION, amyloid protein-binding protein 1, ... | | Authors: | Huang, D.T, Miller, D.W, Mathew, R, Cassell, R, Holton, J.M, Roussel, M.F, Schulman, B.A. | | Deposit date: | 2004-06-21 | | Release date: | 2004-09-14 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
Nat.Struct.Mol.Biol., 11, 2004
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3FN1
 | | E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. | | Descriptor: | NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F | | Authors: | Huang, D.T, Ayrault, O, Hunt, H.W, Taherbhoy, A.M, Duda, D.M, Scott, D.C, Borg, L.A, Neale, G, Murray, P.J, Roussel, M.F, Schulman, B.A. | | Deposit date: | 2008-12-22 | | Release date: | 2009-03-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Mol.Cell, 33, 2009
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1WTL
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1ZKA
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1ZK9
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1SGS
 | | Crystal structure of a free kB DNA | | Descriptor: | CALCIUM ION, kB DNA | | Authors: | Huang, D.B, Phelps, C.B, Fusco, A.J, Ghosh, G. | | Deposit date: | 2004-02-24 | | Release date: | 2004-03-23 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of a free kappaB DNA: insights into DNA recognition by transcription factor NF-kappaB.
J.Mol.Biol., 346, 2005
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4JHB
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4JGM
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1LVE
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2Y1M
 | | Structure of native c-Cbl | | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION | | Authors: | Dou, H, Sibbet, G.J, Huang, D.T. | | Deposit date: | 2010-12-08 | | Release date: | 2012-01-18 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
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2Y1N
 | | Structure of c-Cbl-ZAP-70 peptide complex | | Descriptor: | CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, ... | | Authors: | Dou, H, Sibbet, G.J, Huang, D.T. | | Deposit date: | 2010-12-08 | | Release date: | 2012-01-18 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.999 Å) | | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
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2XPX
 | | Crystal structure of BHRF1:Bak BH3 complex | | Descriptor: | 1,2-ETHANEDIOL, APOPTOSIS REGULATOR BHRF1, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, ... | | Authors: | Kvansakul, M, Huang, D.C.S, Colman, P.M. | | Deposit date: | 2010-08-31 | | Release date: | 2011-01-26 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
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6ZCN
 | | Crystal structure of YTHDC1 with m6A | | Descriptor: | N6-METHYLADENOSINE-5'-MONOPHOSPHATE, SULFATE ION, YTHDC1 | | Authors: | Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. | | Deposit date: | 2020-06-11 | | Release date: | 2020-07-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
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6ZCM
 | | Crystal structure of YTHDC1 with compound DHU_DC1_180 | | Descriptor: | 6-[[cyclopropyl-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1 | | Authors: | Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. | | Deposit date: | 2020-06-11 | | Release date: | 2020-07-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.24 Å) | | Cite: | Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
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7OQO
 | | Crystal structure of the human METTL3-METTL14 complex with compound UOZ111 | | Descriptor: | 2-oxidanyl-N-[[(3R)-3-oxidanyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]methyl]-4-[[(3S)-3-propan-2-yl-2-azaspiro[3.3]heptan-2-yl]methyl]benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | | Deposit date: | 2021-06-03 | | Release date: | 2021-10-20 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
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6SQR
 | | Crystal structure of Cat MDM2-S429E RING domain bound to UbcH5B-Ub | | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase Mdm2, NITRATE ION, ... | | Authors: | Magnussen, H.M, Ahmed, S.F, Huang, D.T. | | Deposit date: | 2019-09-04 | | Release date: | 2020-05-06 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Nat Commun, 11, 2020
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7OQP
 | | Crystal structure of the human METTL3-METTL14 complex with compound UOZ113 | | Descriptor: | ACETATE ION, N-[[(3R)-1-[6-(1-benzothiophen-4-ylmethylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-4-[[(3S)-3-propan-2-yl-2-azaspiro[3.3]heptan-2-yl]methyl]benzamide, N6-adenosine-methyltransferase catalytic subunit, ... | | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | | Deposit date: | 2021-06-03 | | Release date: | 2021-10-20 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
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7OQL
 | | Crystal structure of the human METTL3-METTL14 complex with compound UOZ094 | | Descriptor: | (3~{R})-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-3-[[[6-[[(3~{S})-3-propan-2-yl-2-azoniaspiro[3.3]heptan-2-yl]methyl]naphthalen-1-yl]amino]methyl]piperidin-3-ol, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | | Authors: | Bedi, R.K, Huang, D, Caflisch, A. | | Deposit date: | 2021-06-03 | | Release date: | 2021-10-20 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
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