7OQO

Crystal structure of the human METTL3-METTL14 complex with compound UOZ111

Summary for 7OQO

Entry DOI	10.2210/pdb7oqo/pdb
Descriptor	N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, 2-oxidanyl-N-[[(3R)-3-oxidanyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]methyl]-4-[[(3S)-3-propan-2-yl-2-azaspiro[3.3]heptan-2-yl]methyl]benzamide, ... (5 entities in total)
Functional Keywords	mettl3, inhibitor, complex, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	62343.02
Authors	Bedi, R.K.,Huang, D.,Caflisch, A. (deposition date: 2021-06-03, release date: 2021-10-20, Last modification date: 2024-02-07)
Primary citation	Bedi, R.K.,Huang, D.,Li, Y.,Caflisch, A. Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023 Cited by DOI: 10.1021/acsbiomedchemau.3c00023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.35 Å)

Structure validation