7OQL

Crystal structure of the human METTL3-METTL14 complex with compound UOZ094

Summary for 7OQL

Entry DOI	10.2210/pdb7oql/pdb
Descriptor	N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, (3~{R})-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-3-[[[6-[[(3~{S})-3-propan-2-yl-2-azoniaspiro[3.3]heptan-2-yl]methyl]naphthalen-1-yl]amino]methyl]piperidin-3-ol, ... (5 entities in total)
Functional Keywords	mettl3, inhibitor, complex, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	62416.18
Authors	Bedi, R.K.,Huang, D.,Caflisch, A. (deposition date: 2021-06-03, release date: 2021-10-20, Last modification date: 2024-02-07)
Primary citation	Bedi, R.K.,Huang, D.,Li, Y.,Caflisch, A. Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023 Cited by DOI: 10.1021/acsbiomedchemau.3c00023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation