8Q5D
 
 | | PfRH5 bound to monoclonal antibody MAD10-466 | | Descriptor: | Monoclonal antibody MAD10-466 heavy chain, Monoclonal antibody MAD10-466 light chain, PfRH5 | | Authors: | Farrell, B, Higgins, M.K. | | Deposit date: | 2023-08-08 | | Release date: | 2024-06-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | PfRH5 bound to monoclonal antibody MAD10-466
To Be Published
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6XZ6
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6Z3T
 | | Structure of canine Sec61 inhibited by mycolactone | | Descriptor: | Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... | | Authors: | Gerard, S.F, Higgins, M.K. | | Deposit date: | 2020-05-21 | | Release date: | 2020-07-22 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | Structure of the Inhibited State of the Sec Translocon.
Mol.Cell, 79, 2020
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6ZYV
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7PI3
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7PHV
 | | PfCyRPA bound to monoclonal antibody Cy.007 Fab fragment | | Descriptor: | AMMONIUM ION, Cysteine-rich protective antigen, Monoclonal antibody Cy.007 heavy chain, ... | | Authors: | Ragotte, R.J, Higgins, M.K. | | Deposit date: | 2021-08-18 | | Release date: | 2022-02-09 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.091 Å) | | Cite: | Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.
Nat Commun, 13, 2022
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5MZA
 | | The DBLb domain of PF11_0521 PfEMP1 bound to human ICAM-1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Erythrocyte membrane protein 1 (PfEMP1), ... | | Authors: | Lennartz, F, Higgins, M.K. | | Deposit date: | 2017-01-31 | | Release date: | 2017-03-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.78 Å) | | Cite: | Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria.
Cell Host Microbe, 21, 2017
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7ZXF
 | | Pfs48/45 bound to monoclonal antibodies 10D8 and 85RF45.1 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 85RF45.1 heavy chain, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-20 | | Release date: | 2022-06-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.72 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWF
 | | Pfs48/45 bound to scFv fragment of monoclonal antibody 32F3 | | Descriptor: | 32F3scFv, Gametocyte surface protein P45/48, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.132 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZXG
 | | Pfs48/45 bound to Fab fragment of monoclonal antibody 10D8 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-20 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWM
 | | Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.69 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWI
 | | Pfs48/45 C-terminal domain bound to fab fragment of monoclonal antibody 32F3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 32F3 heavy chain, 32F3 light chain, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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5MI0
 | | A thermally stabilised version of Plasmodium falciparum RH5 | | Descriptor: | MONOCLONAL ANTIBODY 9AD4, Reticulocyte binding-like protein 5,Reticulocyte binding protein 5 | | Authors: | Campeotto, I, Goldenzweig, A, Davey, J, Barfod, L, Marshall, J.M, Silk, S.E, Wright, K.E, Draper, S.J, Higgins, M.K, Fleishman, S.J. | | Deposit date: | 2016-11-27 | | Release date: | 2016-12-28 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8A44
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5LGD
 | | The CIDRa domain from MCvar1 PfEMP1 bound to CD36 | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | Authors: | Hsieh, F.L, Higgins, M.K. | | Deposit date: | 2016-07-06 | | Release date: | 2016-08-31 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | The structural basis for CD36 binding by the malaria parasite.
Nat Commun, 7, 2016
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5NST
 | | Human monoclonal antibody with a LAIR1 insertion | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Heavy Chain of antibody MGD21, ... | | Authors: | Hsieh, F.-L, Higgins, M.K. | | Deposit date: | 2017-04-26 | | Release date: | 2017-10-04 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition.
Elife, 6, 2017
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5JDO
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4U0R
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to monoclonal antibody 9AD4 | | Descriptor: | Monoclonal antibody 9AD4 heavy chain, Monoclonal antibody 9AD4 light chain, Reticulocyte binding protein 5 | | Authors: | Wright, K.E, Hjerrild, K.A, Bartlett, J, Douglas, A.D, Jin, J, Brown, R.E, Ashfield, R, Clemmensen, S.B, de Jongh, W.A, Draper, S.J, Higgins, M.K. | | Deposit date: | 2014-07-14 | | Release date: | 2014-08-13 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies.
Nature, 515, 2014
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4V3D
 | | The CIDRa domain from HB3var03 PfEMP1 bound to endothelial protein C receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ... | | Authors: | Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K. | | Deposit date: | 2014-10-17 | | Release date: | 2014-12-17 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria.
Cell Host Microbe., 17, 2015
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4U1G
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to monoclonal antibody QA1 | | Descriptor: | QA1 monoclonal antibody heavy chain, QA1 monoclonal antibody light chain, Reticulocyte binding protein 5 | | Authors: | Wright, K.E, Hjerrild, K.A, Bartlett, J, Douglas, A.D, Jin, J, Brown, R.E, Ashfield, R, Clemmensen, S.B, de Jongh, W.A, Draper, S.J, Higgins, M.K. | | Deposit date: | 2014-07-15 | | Release date: | 2014-08-13 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies.
Nature, 515, 2014
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4U0Q
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to basigin | | Descriptor: | Basigin, Reticulocyte binding protein 5 | | Authors: | Wright, K.E, Hjerrild, K.A, Bartlett, J, Douglas, A.D, Jin, J, Brown, R.E, Ashfield, R, Clemmensen, S.B, de Jongh, W.A, Draper, S.J, Higgins, M.K. | | Deposit date: | 2014-07-14 | | Release date: | 2014-08-13 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies.
Nature, 515, 2014
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7PHU
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7PI7
 | | PfCyRPA bound to monoclonal antibody Cy.002 Fab fragment | | Descriptor: | Cysteine-rich protective antigen, Monoclonal antibody Cy.002 heavy chain, Monoclonal antibody Cy.002 light chain | | Authors: | Ragotte, R.J, Higgins, M.K. | | Deposit date: | 2021-08-19 | | Release date: | 2022-02-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.
Nat Commun, 13, 2022
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7PHW
 | | PfCyRPA bound to monoclonal antibody Cy.004 Fab fragment | | Descriptor: | CALCIUM ION, Cysteine-rich protective antigen, Monoclonal antibody Cy.004 heavy chain, ... | | Authors: | Ragotte, R.J, Higgins, M.K. | | Deposit date: | 2021-08-18 | | Release date: | 2022-02-09 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.793 Å) | | Cite: | Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.
Nat Commun, 13, 2022
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7PI2
 | | PfCyRPA bound to monoclonal antibody Cy.003 Fab fragment | | Descriptor: | Cysteine-rich protective antigen, Monoclonal antibody Cy.003 heavy chain, Monoclonal antibody Cy.003 light chain | | Authors: | Ragotte, R.J, Higgins, M.K. | | Deposit date: | 2021-08-19 | | Release date: | 2022-02-09 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.14 Å) | | Cite: | Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.
Nat Commun, 13, 2022
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