5MZA

The DBLb domain of PF11_0521 PfEMP1 bound to human ICAM-1

Summary for 5MZA

Entry DOI	10.2210/pdb5mza/pdb
Descriptor	Erythrocyte membrane protein 1 (PfEMP1), Intercellular adhesion molecule 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	pfemp1 icam-1 cerebral malaria, cell adhesion
Biological source	Plasmodium falciparum 3D7 More
Total number of polymer chains	2
Total formula weight	77797.55
Authors	Lennartz, F.,Higgins, M.K. (deposition date: 2017-01-31, release date: 2017-03-22, Last modification date: 2020-10-07)
Primary citation	Lennartz, F.,Adams, Y.,Bengtsson, A.,Olsen, R.W.,Turner, L.,Ndam, N.T.,Ecklu-Mensah, G.,Moussiliou, A.,Ofori, M.F.,Gamain, B.,Lusingu, J.P.,Petersen, J.E.,Wang, C.W.,Nunes-Silva, S.,Jespersen, J.S.,Lau, C.K.,Theander, T.G.,Lavstsen, T.,Hviid, L.,Higgins, M.K.,Jensen, A.T. Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria. Cell Host Microbe, 21:403-414, 2017 Cited by PubMed: 28279348 DOI: 10.1016/j.chom.2017.02.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.78 Å)

Structure validation