5JDO
T. congolense haptoglobin-haemoglobin receptor in complex with haemoglobin
Summary for 5JDO
| Entry DOI | 10.2210/pdb5jdo/pdb |
| Descriptor | Haptoglobin-haemoglobin receptor, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... (8 entities in total) |
| Functional Keywords | trypanosome, haptoglobin-haemoglobin receptor, haemoglobin, epimastigote, oxygen transport |
| Biological source | Trypanosoma congolense More |
| Total number of polymer chains | 6 |
| Total formula weight | 116862.13 |
| Authors | Lane-Serff, H.,Higgins, M.K. (deposition date: 2016-04-17, release date: 2016-04-27, Last modification date: 2024-11-06) |
| Primary citation | Lane-Serff, H.,MacGregor, P.,Peacock, L.,Macleod, O.J.,Kay, C.,Gibson, W.,Higgins, M.K.,Carrington, M. Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor. Elife, 5:-, 2016 Cited by PubMed Abstract: The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes. Here we show that in Trypanosoma congolense this receptor is instead expressed in the epimastigote developmental stage that occurs in the tsetse fly, where it acts as a haemoglobin receptor. We also present the structure of the T. congolense receptor in complex with haemoglobin. This allows us to propose an evolutionary history for this receptor, charting the structural and cellular changes that took place as it adapted from a role in the insect to a new role in the mammalian host. PubMed: 27083048DOI: 10.7554/eLife.13044 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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