Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5JDO

T. congolense haptoglobin-haemoglobin receptor in complex with haemoglobin

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0005833	cellular_component	hemoglobin complex
C	0006954	biological_process	inflammatory response
C	0015670	biological_process	carbon dioxide transport
C	0015671	biological_process	oxygen transport
C	0016020	cellular_component	membrane
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0030185	biological_process	nitric oxide transport
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042542	biological_process	response to hydrogen peroxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0046872	molecular_function	metal ion binding
C	0048821	biological_process	erythrocyte development
C	0070062	cellular_component	extracellular exosome
C	0071682	cellular_component	endocytic vesicle lumen
C	0072562	cellular_component	blood microparticle
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005829	cellular_component	cytosol
D	0005833	cellular_component	hemoglobin complex
D	0006954	biological_process	inflammatory response
D	0008217	biological_process	regulation of blood pressure
D	0015670	biological_process	carbon dioxide transport
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0030185	biological_process	nitric oxide transport
D	0030492	molecular_function	hemoglobin binding
D	0031720	molecular_function	haptoglobin binding
D	0031721	molecular_function	hemoglobin alpha binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042542	biological_process	response to hydrogen peroxide
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0048821	biological_process	erythrocyte development
D	0070062	cellular_component	extracellular exosome
D	0070293	biological_process	renal absorption
D	0070527	biological_process	platelet aggregation
D	0071682	cellular_component	endocytic vesicle lumen
D	0072562	cellular_component	blood microparticle
D	0097746	biological_process	blood vessel diameter maintenance
D	0098869	biological_process	cellular oxidant detoxification
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0004601	molecular_function	peroxidase activity
E	0005344	molecular_function	oxygen carrier activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005829	cellular_component	cytosol
E	0005833	cellular_component	hemoglobin complex
E	0006954	biological_process	inflammatory response
E	0015670	biological_process	carbon dioxide transport
E	0015671	biological_process	oxygen transport
E	0016020	cellular_component	membrane
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0030185	biological_process	nitric oxide transport
E	0031720	molecular_function	haptoglobin binding
E	0031838	cellular_component	haptoglobin-hemoglobin complex
E	0042542	biological_process	response to hydrogen peroxide
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0046872	molecular_function	metal ion binding
E	0048821	biological_process	erythrocyte development
E	0070062	cellular_component	extracellular exosome
E	0071682	cellular_component	endocytic vesicle lumen
E	0072562	cellular_component	blood microparticle
E	0098869	biological_process	cellular oxidant detoxification
F	0004601	molecular_function	peroxidase activity
F	0005344	molecular_function	oxygen carrier activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005829	cellular_component	cytosol
F	0005833	cellular_component	hemoglobin complex
F	0006954	biological_process	inflammatory response
F	0008217	biological_process	regulation of blood pressure
F	0015670	biological_process	carbon dioxide transport
F	0015671	biological_process	oxygen transport
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0030185	biological_process	nitric oxide transport
F	0030492	molecular_function	hemoglobin binding
F	0031720	molecular_function	haptoglobin binding
F	0031721	molecular_function	hemoglobin alpha binding
F	0031838	cellular_component	haptoglobin-hemoglobin complex
F	0042542	biological_process	response to hydrogen peroxide
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0048821	biological_process	erythrocyte development
F	0070062	cellular_component	extracellular exosome
F	0070293	biological_process	renal absorption
F	0070527	biological_process	platelet aggregation
F	0071682	cellular_component	endocytic vesicle lumen
F	0072562	cellular_component	blood microparticle
F	0097746	biological_process	blood vessel diameter maintenance
F	0098869	biological_process	cellular oxidant detoxification
F	1904724	cellular_component	tertiary granule lumen
F	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue HEM C 201

Chain	Residue
B	SER29
C	LYS62
C	LEU84
C	LEU87
C	HIS88
C	LEU92
C	VAL94
C	ASN98
C	PHE99
C	LEU137
C	OXY202
B	ILE30
B	THR166
B	TYR168
C	TYR43
C	PHE44
C	HIS46
C	PHE47
C	HIS59

site_id	AC2
Number of Residues	5
Details	binding site for residue OXY C 202

Chain	Residue
C	LEU30
C	PHE44
C	HIS59
C	VAL63
C	HEM201

site_id	AC3
Number of Residues	15
Details	binding site for residue HEM D 201

Chain	Residue
A	ARG42
A	LYS52
D	PHE42
D	HIS64
D	LYS67
D	VAL68
D	ALA71
D	LEU89
D	HIS93
D	VAL99
D	ASN103
D	PHE104
D	LEU107
D	LEU142
D	OXY202

site_id	AC4
Number of Residues	5
Details	binding site for residue OXY D 202

Chain	Residue
D	LEU29
D	PHE43
D	HIS64
D	VAL68
D	HEM201

site_id	AC5
Number of Residues	16
Details	binding site for residue HEM E 201

Chain	Residue
A	SER29
A	THR166
E	TYR43
E	PHE44
E	HIS46
E	PHE47
E	HIS59
E	LYS62
E	ALA66
E	HIS88
E	LEU92
E	VAL94
E	ASN98
E	PHE99
E	LEU137
E	OXY202

site_id	AC6
Number of Residues	4
Details	binding site for residue OXY E 202

Chain	Residue
E	LEU30
E	HIS59
E	VAL63
E	HEM201

site_id	AC7
Number of Residues	16
Details	binding site for residue HEM F 201

Chain	Residue
B	ARG42
B	LYS52
F	PHE42
F	PHE43
F	HIS64
F	LYS67
F	VAL68
F	ALA71
F	HIS93
F	LEU97
F	VAL99
F	ASN103
F	PHE104
F	LEU107
F	LEU142
F	OXY202

site_id	AC8
Number of Residues	3
Details	binding site for residue OXY F 202

Chain	Residue
F	HIS64
F	VAL68
F	HEM201

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
F	HIS3
F	LYS83
F	HIS144

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: distal binding residue

Chain	Residue	Details
F	HIS64

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: proximal binding residue

Chain	Residue	Details
F	HIS93
E	LEU92
E	LEU107
E	THR109
E	VAL122
E	SER134
E	ALA14
E	TYR25
E	LEU30
E	HIS46
E	ASP48
E	SER53
E	VAL56
E	GLY60

site_id	SWS_FT_FI4
Number of Residues	19
Details	SITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269\|PubMed:12552433

Chain	Residue	Details
F	GLU8
F	GLY75
F	THR85
F	HIS93
F	ARG105
F	LEU111
F	GLY120
F	PHE123
F	ALA129
F	ALA141
F	LYS145
F	GLY26
F	GLY30
F	TYR36
F	TRP38
F	PHE46
F	ASP53
F	GLY57
F	PHE72

site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Not glycated => ECO:0000269\|PubMed:7358733

Chain	Residue	Details
F	LYS60
F	LYS83
F	LYS96

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
F	SER10
F	SER45
E	LYS41

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
F	THR13
F	THR51
F	THR88

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:4531009

Chain	Residue	Details
F	LYS60
F	LYS83

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: S-nitrosocysteine => ECO:0000269\|PubMed:8637569, ECO:0000269\|PubMed:9843411

Chain	Residue	Details
F	CYS94

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269\|PubMed:4531009

Chain	Residue	Details
F	LYS145
E	SER125
E	SER132
E	SER139

site_id	SWS_FT_FI11
Number of Residues	4
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269\|PubMed:7358733

Chain	Residue	Details
F	LYS9
F	LYS18
F	LYS67
F	LYS121

site_id	SWS_FT_FI12
Number of Residues	1
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269\|PubMed:7358733

Chain	Residue	Details
F	LYS145
E	LYS17
E	LYS41

site_id	SWS_FT_FI13
Number of Residues	1
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269\|PubMed:7358733

Chain	Residue	Details
E	LYS62

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)