5JDO
T. congolense haptoglobin-haemoglobin receptor in complex with haemoglobin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004601 | molecular_function | peroxidase activity |
| C | 0005344 | molecular_function | oxygen carrier activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005829 | cellular_component | cytosol |
| C | 0005833 | cellular_component | hemoglobin complex |
| C | 0006954 | biological_process | inflammatory response |
| C | 0015670 | biological_process | carbon dioxide transport |
| C | 0015671 | biological_process | oxygen transport |
| C | 0016020 | cellular_component | membrane |
| C | 0019825 | molecular_function | oxygen binding |
| C | 0020037 | molecular_function | heme binding |
| C | 0030185 | biological_process | nitric oxide transport |
| C | 0031720 | molecular_function | haptoglobin binding |
| C | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| C | 0042542 | biological_process | response to hydrogen peroxide |
| C | 0042744 | biological_process | hydrogen peroxide catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048821 | biological_process | erythrocyte development |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0071682 | cellular_component | endocytic vesicle lumen |
| C | 0072562 | cellular_component | blood microparticle |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0004601 | molecular_function | peroxidase activity |
| D | 0005344 | molecular_function | oxygen carrier activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005829 | cellular_component | cytosol |
| D | 0005833 | cellular_component | hemoglobin complex |
| D | 0006954 | biological_process | inflammatory response |
| D | 0008217 | biological_process | regulation of blood pressure |
| D | 0015670 | biological_process | carbon dioxide transport |
| D | 0015671 | biological_process | oxygen transport |
| D | 0019825 | molecular_function | oxygen binding |
| D | 0020037 | molecular_function | heme binding |
| D | 0030185 | biological_process | nitric oxide transport |
| D | 0030492 | molecular_function | hemoglobin binding |
| D | 0031720 | molecular_function | haptoglobin binding |
| D | 0031721 | molecular_function | hemoglobin alpha binding |
| D | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| D | 0042542 | biological_process | response to hydrogen peroxide |
| D | 0042744 | biological_process | hydrogen peroxide catabolic process |
| D | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048821 | biological_process | erythrocyte development |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0070293 | biological_process | renal absorption |
| D | 0070527 | biological_process | platelet aggregation |
| D | 0071682 | cellular_component | endocytic vesicle lumen |
| D | 0072562 | cellular_component | blood microparticle |
| D | 0097746 | biological_process | blood vessel diameter maintenance |
| D | 0098869 | biological_process | cellular oxidant detoxification |
| D | 1904724 | cellular_component | tertiary granule lumen |
| D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| E | 0004601 | molecular_function | peroxidase activity |
| E | 0005344 | molecular_function | oxygen carrier activity |
| E | 0005506 | molecular_function | iron ion binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005615 | cellular_component | extracellular space |
| E | 0005829 | cellular_component | cytosol |
| E | 0005833 | cellular_component | hemoglobin complex |
| E | 0006954 | biological_process | inflammatory response |
| E | 0015670 | biological_process | carbon dioxide transport |
| E | 0015671 | biological_process | oxygen transport |
| E | 0016020 | cellular_component | membrane |
| E | 0019825 | molecular_function | oxygen binding |
| E | 0020037 | molecular_function | heme binding |
| E | 0030185 | biological_process | nitric oxide transport |
| E | 0031720 | molecular_function | haptoglobin binding |
| E | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| E | 0042542 | biological_process | response to hydrogen peroxide |
| E | 0042744 | biological_process | hydrogen peroxide catabolic process |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0048821 | biological_process | erythrocyte development |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0071682 | cellular_component | endocytic vesicle lumen |
| E | 0072562 | cellular_component | blood microparticle |
| E | 0098869 | biological_process | cellular oxidant detoxification |
| F | 0004601 | molecular_function | peroxidase activity |
| F | 0005344 | molecular_function | oxygen carrier activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005615 | cellular_component | extracellular space |
| F | 0005829 | cellular_component | cytosol |
| F | 0005833 | cellular_component | hemoglobin complex |
| F | 0006954 | biological_process | inflammatory response |
| F | 0008217 | biological_process | regulation of blood pressure |
| F | 0015670 | biological_process | carbon dioxide transport |
| F | 0015671 | biological_process | oxygen transport |
| F | 0019825 | molecular_function | oxygen binding |
| F | 0020037 | molecular_function | heme binding |
| F | 0030185 | biological_process | nitric oxide transport |
| F | 0030492 | molecular_function | hemoglobin binding |
| F | 0031720 | molecular_function | haptoglobin binding |
| F | 0031721 | molecular_function | hemoglobin alpha binding |
| F | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| F | 0042542 | biological_process | response to hydrogen peroxide |
| F | 0042744 | biological_process | hydrogen peroxide catabolic process |
| F | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0048821 | biological_process | erythrocyte development |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 0070293 | biological_process | renal absorption |
| F | 0070527 | biological_process | platelet aggregation |
| F | 0071682 | cellular_component | endocytic vesicle lumen |
| F | 0072562 | cellular_component | blood microparticle |
| F | 0097746 | biological_process | blood vessel diameter maintenance |
| F | 0098869 | biological_process | cellular oxidant detoxification |
| F | 1904724 | cellular_component | tertiary granule lumen |
| F | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue HEM C 201 |
| Chain | Residue |
| B | SER29 |
| C | LYS62 |
| C | LEU84 |
| C | LEU87 |
| C | HIS88 |
| C | LEU92 |
| C | VAL94 |
| C | ASN98 |
| C | PHE99 |
| C | LEU137 |
| C | OXY202 |
| B | ILE30 |
| B | THR166 |
| B | TYR168 |
| C | TYR43 |
| C | PHE44 |
| C | HIS46 |
| C | PHE47 |
| C | HIS59 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue OXY C 202 |
| Chain | Residue |
| C | LEU30 |
| C | PHE44 |
| C | HIS59 |
| C | VAL63 |
| C | HEM201 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue HEM D 201 |
| Chain | Residue |
| A | ARG42 |
| A | LYS52 |
| D | PHE42 |
| D | HIS64 |
| D | LYS67 |
| D | VAL68 |
| D | ALA71 |
| D | LEU89 |
| D | HIS93 |
| D | VAL99 |
| D | ASN103 |
| D | PHE104 |
| D | LEU107 |
| D | LEU142 |
| D | OXY202 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue OXY D 202 |
| Chain | Residue |
| D | LEU29 |
| D | PHE43 |
| D | HIS64 |
| D | VAL68 |
| D | HEM201 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue HEM E 201 |
| Chain | Residue |
| A | SER29 |
| A | THR166 |
| E | TYR43 |
| E | PHE44 |
| E | HIS46 |
| E | PHE47 |
| E | HIS59 |
| E | LYS62 |
| E | ALA66 |
| E | HIS88 |
| E | LEU92 |
| E | VAL94 |
| E | ASN98 |
| E | PHE99 |
| E | LEU137 |
| E | OXY202 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue OXY E 202 |
| Chain | Residue |
| E | LEU30 |
| E | HIS59 |
| E | VAL63 |
| E | HEM201 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue HEM F 201 |
| Chain | Residue |
| B | ARG42 |
| B | LYS52 |
| F | PHE42 |
| F | PHE43 |
| F | HIS64 |
| F | LYS67 |
| F | VAL68 |
| F | ALA71 |
| F | HIS93 |
| F | LEU97 |
| F | VAL99 |
| F | ASN103 |
| F | PHE104 |
| F | LEU107 |
| F | LEU142 |
| F | OXY202 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue OXY F 202 |
| Chain | Residue |
| F | HIS64 |
| F | VAL68 |
| F | HEM201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Peptide: {"description":"Hemopressin","featureId":"PRO_0000455882","evidences":[{"source":"PubMed","id":"18077343","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 284 |
| Details | Domain: {"description":"Globin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"proximal binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 66 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by N.americanus apr-2","evidences":[{"source":"PubMed","id":"12552433","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; alternate","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 10 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 18 |
| Details | Peptide: {"description":"LVV-hemorphin-7","featureId":"PRO_0000296641"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 12 |
| Details | Peptide: {"description":"Spinorphin","featureId":"PRO_0000424226"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"distal binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"proximal binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"4531009","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"8637569","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9843411","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"4531009","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
