5V4Q
| Crystal Structure of human GGT1 in complex with DON | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5,5-dihydroxy-L-norleucine, CHLORIDE ION, ... | 著者 | Terzyan, S, Hanigan, M. | 登録日 | 2017-03-10 | 公開日 | 2017-04-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation. Protein Sci., 26, 2017
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6XPC
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4ZCG
| Crystal Structure of human GGT1 in complex with Glutamate (with all atoms of glutamate) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLUTAMIC ACID, ... | 著者 | Terzyan, S, Hanigan, M. | 登録日 | 2015-04-15 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J.Biol.Chem., 290, 2015
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4ZBK
| Crystal Structure of human GGT1 in complex with GGsTop inhibitor | 分子名称: | (2S)-2-amino-4-[(S)-hydroxy(methoxy)phosphoryl]butanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Terzyan, S, Hanigan, M. | 登録日 | 2015-04-14 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J.Biol.Chem., 290, 2015
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4ZC6
| Crystal Structure of human GGT1 in complex with Serine Borate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Gamma-glutamyltranspeptidase 1 heavy chain, ... | 著者 | Terzyan, S, Hanigan, M. | 登録日 | 2015-04-15 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J.Biol.Chem., 290, 2015
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7LBC
| Structure of human GGT1 in complex with Lnt2-65 compound | 分子名称: | (2R)-2-[(2-aminoethyl)amino]-4-boronobutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Terzyan, S.S, Hanigan, M. | 登録日 | 2021-01-07 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase. Bioorg.Med.Chem., 73, 2022
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7LD9
| Structure of human GGT1 in complex with ABBA | 分子名称: | (2R)-2-amino-4-boronobutanoic acid, (2S)-2-amino-4-boronobutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Terzyan, S.S, Hanigan, M. | 登録日 | 2021-01-12 | 公開日 | 2022-02-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase. Bioorg.Med.Chem., 73, 2022
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6XPB
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4Z9O
| Crystal Structure of human GGT1 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Terzyan, S.S, Hanigan, M.H. | 登録日 | 2015-04-10 | 公開日 | 2015-06-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J.Biol.Chem., 290, 2015
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4GG2
| The crystal structure of glutamate-bound human gamma-glutamyltranspeptidase 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLUTAMIC ACID, ... | 著者 | West, M.B, Chen, Y, Wickham, S, Heroux, A, Cahill, K, Hanigan, M.H, Mooers, B.H.M. | 登録日 | 2012-08-04 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Novel Insights into Eukaryotic gamma-Glutamyltranspeptidase 1 from the Crystal Structure of the Glutamate-bound Human Enzyme. J.Biol.Chem., 288, 2013
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4GDX
| Crystal Structure of Human Gamma-Glutamyl Transpeptidase--Glutamate complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLUTAMIC ACID, ... | 著者 | West, M.B, Chen, Y, Wickham, S, Heroux, A, Cahill, K, Hanigan, M.H, Mooers, B.H.M. | 登録日 | 2012-08-01 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Novel Insights into Eukaryotic gamma-Glutamyltranspeptidase 1 from the Crystal Structure of the Glutamate-bound Human Enzyme. J.Biol.Chem., 288, 2013
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7LA5
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