6XPB
Structure of human GGT1 in complex with 2-amino-4-(((1-((carboxymethyl)amino)-1-oxobutan-2-yl)oxy)(phenoxy)phosphoryl)butanoic acid (ACPB) molecule
Summary for 6XPB
Entry DOI | 10.2210/pdb6xpb/pdb |
Descriptor | Glutathione hydrolase 1 heavy chain, Glutathione hydrolase 1 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | inhibitor-enzyme complex, ntn-hydrolase family, glycoprotein, n-glycosylation, cell surface, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 60370.60 |
Authors | Terzyan, S.S.,Hanigan, M.H. (deposition date: 2020-07-08, release date: 2020-11-25, Last modification date: 2023-10-18) |
Primary citation | Terzyan, S.S.,Nguyen, L.T.,Burgett, A.W.G.,Heroux, A.,Smith, C.A.,You, Y.,Hanigan, M.H. Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site. J.Biol.Chem., 296:100066-100066, 2020 Cited by PubMed: 33187988DOI: 10.1074/jbc.RA120.016265 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
Download full validation report