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6XPB

Structure of human GGT1 in complex with 2-amino-4-(((1-((carboxymethyl)amino)-1-oxobutan-2-yl)oxy)(phenoxy)phosphoryl)butanoic acid (ACPB) molecule

Summary for 6XPB
Entry DOI10.2210/pdb6xpb/pdb
DescriptorGlutathione hydrolase 1 heavy chain, Glutathione hydrolase 1 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywordsinhibitor-enzyme complex, ntn-hydrolase family, glycoprotein, n-glycosylation, cell surface, hydrolase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight60370.60
Authors
Terzyan, S.S.,Hanigan, M.H. (deposition date: 2020-07-08, release date: 2020-11-25, Last modification date: 2023-10-18)
Primary citationTerzyan, S.S.,Nguyen, L.T.,Burgett, A.W.G.,Heroux, A.,Smith, C.A.,You, Y.,Hanigan, M.H.
Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site.
J.Biol.Chem., 296:100066-100066, 2020
Cited by
PubMed: 33187988
DOI: 10.1074/jbc.RA120.016265
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.74 Å)
Structure validation

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