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PDB: 739 件

4GE5
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Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 5
分子名称: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9
著者Zhang, Z.-Y, Liu, S, Zhang, S.
登録日2012-08-01
公開日2012-10-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
J.Am.Chem.Soc., 134, 2012
2XPI
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BU of 2xpi by Molmil
Crystal structure of APC/C hetero-tetramer Cut9-Hcn1
分子名称: ANAPHASE-PROMOTING COMPLEX SUBUNIT CUT9, ANAPHASE-PROMOTING COMPLEX SUBUNIT HCN1 HCN1/CDC26,20S CYCLOSOME/APC COMPLEX PROTEIN HCN1, CHAPERONE-LIKE PROTEIN HCN1, ...
著者Zhang, Z, Kulkarni, K.A, Barford, D.
登録日2010-08-26
公開日2011-03-30
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Apc/C Subunit Cdc16/Cut9 is a Contiguous Tetratricopeptide Superhelix with a Homo-Dimer Interface Similar to Cdc27
Embo J., 29, 2010
8HVT
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BU of 8hvt by Molmil
Structure of the human CLC-7/Ostm1 complex reveals a novel state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, H(+)/Cl(-) exchange transporter 7, Osteopetrosis-associated transmembrane protein 1, ...
著者Zhang, Z.X, Chen, L, He, J, She, J.
登録日2022-12-27
公開日2024-01-03
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structure of the human CLC-7/Ostm1 complex reveals a novel state
To Be Published
5W81
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Phosphorylated, ATP-bound structure of zebrafish cystic fibrosis transmembrane conductance regulator (CFTR)
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION
著者Zhang, Z, Liu, F, Chen, J.
登録日2017-06-21
公開日2017-07-19
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.37 Å)
主引用文献Conformational Changes of CFTR upon Phosphorylation and ATP Binding.
Cell, 170, 2017
1HQW
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CRYSTAL STRUCTURE OF THE COMPLEX OF CONCANAVALIN A WITH A TRIPEPTIDE YPY
分子名称: CALCIUM ION, CONCANAVALIN A, MANGANESE (II) ION, ...
著者Zhang, Z, Qian, M, Huang, Q, Jia, Y, Tang, Y, Wang, K, Cui, D, Li, M.
登録日2000-12-20
公開日2003-10-07
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the complex of concanavalin A and tripeptide
J.PROTEIN CHEM., 20, 2001
1WA6
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BU of 1wa6 by Molmil
The structure of ACC oxidase
分子名称: 1-AMINOCYCLOPROPANE-1-CARBOXYLATE OXIDASE 1, FE (II) ION, PHOSPHATE ION, ...
著者Zhang, Z, Ren, J.-S, Clifton, I.J, Schofield, C.J.
登録日2004-10-25
公開日2005-10-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal Structure and Mechanistic Implications of 1-Aminocyclopropane-1-Carboxylic Acid Oxidase (the Ethyling Forming Enzyme)
Chem.Biol., 11, 2004
3MOW
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BU of 3mow by Molmil
Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1
分子名称: (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10S,12S,15E,17E)-18-carboxy-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5-oxooctade ca-15,17-dien-1-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, Tyrosine-protein phosphatase non-receptor type 11
著者Zhang, Z.-Y, Liu, S, Yu, Z, Yu, X.
登録日2010-04-23
公開日2011-05-04
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1
To be Published
3H1H
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Cytochrome bc1 complex from chicken
分子名称: 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, CARDIOLIPIN, CYTOCHROME C1, ...
著者Zhang, Z, Huang, L, Shulmeister, V.M, Chi, Y.I, Kim, K.K, Hung, L.W, Crofts, A.R, Berry, E.A, Kim, S.H.
登録日2009-04-12
公開日2009-04-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.16 Å)
主引用文献Electron Transfer by Domain Movement in Cytochrome Bc1
Nature, 392, 1998
4GE6
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BU of 4ge6 by Molmil
Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 7
分子名称: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithyl-3-{[(4-hydroxy-3-methoxyphenyl)acetyl]amino}-D-alaninamide, Tyrosine-protein phosphatase non-receptor type 9
著者Zhang, Z.-Y, Liu, S, Zhang, S.
登録日2012-08-01
公開日2012-10-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
J.Am.Chem.Soc., 134, 2012
6K9H
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BU of 6k9h by Molmil
Human LXR-beta in complex with an agonist
分子名称: Oxysterols receptor LXR-beta, ~{tert}-butyl (2'~{S},3~{S})-2-oxidanylidene-2'-phenyl-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate
著者Zhang, Z, Zhou, H.
登録日2019-06-15
公開日2020-04-22
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of new LXR beta agonists as glioblastoma inhibitors.
Eur.J.Med.Chem., 194, 2020
7UZM
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BU of 7uzm by Molmil
Glutamate dehydrogenase 1 from human liver
分子名称: Glutamate dehydrogenase 1, mitochondrial
著者Zhang, Z.
登録日2022-05-09
公開日2023-05-03
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
1M4Z
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BU of 1m4z by Molmil
Crystal structure of the N-terminal BAH domain of Orc1p
分子名称: MANGANESE (II) ION, ORIGIN RECOGNITION COMPLEX SUBUNIT 1
著者Zhang, Z, Hayashi, M.K, Merkel, O, Stillman, B, Xu, R.-M.
登録日2002-07-05
公開日2002-09-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing.
EMBO J., 21, 2002
6K9G
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BU of 6k9g by Molmil
Human LXR-beta in complex with an agonist
分子名称: Oxysterols receptor LXR-beta, ~{tert}-butyl (2'~{R},3~{R})-2'-[3-[4-(hydroxymethyl)-3-methylsulfonyl-phenyl]phenyl]-2-oxidanylidene-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate
著者Zhang, Z, Zhou, H.
登録日2019-06-15
公開日2020-04-22
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of new LXR beta agonists as glioblastoma inhibitors.
Eur.J.Med.Chem., 194, 2020
6K9M
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BU of 6k9m by Molmil
Human LXR-beta in complex with an agonist
分子名称: Oxysterols receptor LXR-beta, ~{tert}-butyl (2'~{S},3~{S})-2-oxidanylidene-2'-propan-2-yl-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate
著者Zhang, Z, Zhou, H.
登録日2019-06-16
公開日2020-06-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors.
Eur.J.Med.Chem., 206, 2020
3G0C
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BU of 3g0c by Molmil
Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(2-chlorobenzyl)-1,3-dimethyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione, ...
著者Zhang, Z, Wallace, M.B, Feng, J, Stafford, J.A, Kaldor, S.W, Shi, L, Skene, R.J, Aertgeerts, K, Lee, B, Jennings, A, Xu, R, Kassel, D, Webb, D.R, Gwaltney, S.L.
登録日2009-01-27
公開日2010-02-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV.
J.Med.Chem., 54, 2011
3G0D
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Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 2
分子名称: 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Wallace, M.B, Feng, J, Stafford, J.A, Kaldor, S.W, Shi, L, Skene, R.J, Aertgeerts, K, Lee, B, Jennings, A, Xu, R, Kassel, D, Webb, D.R, Gwaltney, S.L.
登録日2009-01-27
公開日2010-02-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV.
J.Med.Chem., 54, 2011
3VAX
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BU of 3vax by Molmil
Crystal structure of DndA from streptomyces lividans
分子名称: PYRIDOXAL-5'-PHOSPHATE, Putative uncharacterized protein dndA
著者Zhang, Z, Chen, F, Lin, K, Wu, G.
登録日2011-12-30
公開日2013-01-02
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the cysteine desulfurase DndA from Streptomyces lividans which is involved in DNA phosphorothioation
Plos One, 7, 2012
7YTP
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BU of 7ytp by Molmil
TLR7 in complex with an inhibitor
分子名称: (2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2022-08-15
公開日2023-11-15
実験手法ELECTRON MICROSCOPY (2.77 Å)
主引用文献TLR7 in complex with an inhibitor
To Be Published
3MSR
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BU of 3msr by Molmil
The crystal structure of an amidohydrolase from Mycoplasma synoviae
分子名称: GLYCEROL, PHOSPHATE ION, amidohydrolases
著者Zhang, Z, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2010-04-29
公開日2010-05-12
最終更新日2021-02-10
実験手法X-RAY DIFFRACTION (2.162 Å)
主引用文献The crystal structure of an amidohydrolase from Mycoplasma synoviae
To be Published
7VGR
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BU of 7vgr by Molmil
SARS-CoV-2 M protein dimer (long form) in complex with YN7756_1 Fab
分子名称: Membrane protein, YN7756_1 Fab heavy chain, YN7756_1 Fab light chain
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2021-09-18
公開日2022-08-03
最終更新日2023-08-16
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structure of SARS-CoV-2 membrane protein essential for virus assembly.
Nat Commun, 13, 2022
7VGS
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BU of 7vgs by Molmil
SARS-CoV-2 M protein dimer (short form) in complex with YN7717_9 Fab
分子名称: Membrane protein, YN7717_9 Fab heavy chain, YN7717_9 Fab light chain
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2021-09-18
公開日2022-08-03
最終更新日2023-08-16
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structure of SARS-CoV-2 membrane protein essential for virus assembly.
Nat Commun, 13, 2022
3G0G
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Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinone inhibitor 3
分子名称: 2-({2-[(3R)-3-aminopiperidin-1-yl]-5-bromo-6-oxopyrimidin-1(6H)-yl}methyl)benzonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Wallace, M.B, Feng, J, Stafford, J.A, Kaldor, S.W, Shi, L, Skene, R.J, Aertgeerts, K, Lee, B, Jennings, A, Xu, R, Kassel, D, Webb, D.R, Gwaltney, S.L.
登録日2009-01-27
公開日2010-02-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV.
J.Med.Chem., 54, 2011
3NMW
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Crystal structure of armadillo repeats domain of APC
分子名称: APC variant protein, SULFATE ION
著者Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G.
登録日2010-06-22
公開日2011-07-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis for the recognition of Asef by adenomatous polyposis coli.
Cell Res., 22, 2012
3NMZ
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Crystal structure of APC complexed with Asef
分子名称: APC variant protein, Rho guanine nucleotide exchange factor 4
著者Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G.
登録日2010-06-23
公開日2011-07-06
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Structural basis for the recognition of Asef by adenomatous polyposis coli.
Cell Res., 22, 2012
3NMX
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Crystal structure of APC complexed with Asef
分子名称: APC variant protein, Rho guanine nucleotide exchange factor 4
著者Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G.
登録日2010-06-22
公開日2011-07-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for the recognition of Asef by adenomatous polyposis coli.
Cell Res., 22, 2012

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