3G0C

Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 1

Summary for 3G0C

• Entry DOI: 10.2210/pdb3g0c/pdb
• Related: 3G0B 3G0D 3G0G
• Descriptor: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(2-chlorobenzyl)-1,3-dimethyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione, ... (5 entities in total)
• Functional Keywords: dpp4, pyrimidinone, pyrimidindione, aminopeptidase, cell membrane, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 349435.68

Authors

Zhang, Z.,Wallace, M.B.,Feng, J.,Stafford, J.A.,Kaldor, S.W.,Shi, L.,Skene, R.J.,Aertgeerts, K.,Lee, B.,Jennings, A.,Xu, R.,Kassel, D.,Webb, D.R.,Gwaltney, S.L. (deposition date: 2009-01-27, release date: 2010-02-16, Last modification date: 2023-09-06)

• Primary citation: Zhang, Z.,Wallace, M.B.,Feng, J.,Stafford, J.A.,Skene, R.J.,Shi, L.,Lee, B.,Aertgeerts, K.,Jennings, A.,Xu, R.,Kassel, D.B.,Kaldor, S.W.,Navre, M.,Webb, D.R.,Gwaltney, S.L.; Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV.; J.Med.Chem., 54:510-524, 2011; PubMed: 21186796; DOI: 10.1021/jm101016w

Experimental method

X-RAY DIFFRACTION (2.69 Å)