5CRZ
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![BU of 5crz by Molmil](/molmil-images/mine/5crz) | Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand | Descriptor: | 1,2-ETHANEDIOL, 2-chloro-N-(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)-4-fluorobenzenesulfonamide, Bromodomain-containing protein 4, ... | Authors: | Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. | Deposit date: | 2015-07-23 | Release date: | 2016-01-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
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3SWC
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![BU of 3swc by Molmil](/molmil-images/mine/3swc) | GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me2 peptide | Descriptor: | DNA (cytosine-5)-methyltransferase 3A, Histone-lysine N-methyltransferase EHMT1, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Chang, Y, Horton, J.R, Zhang, X, Cheng, X. | Deposit date: | 2011-07-13 | Release date: | 2011-11-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.332 Å) | Cite: | MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun, 2, 2011
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6LCY
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![BU of 6lcy by Molmil](/molmil-images/mine/6lcy) | Crystal structure of Synaptotagmin-7 C2B in complex with IP6 | Descriptor: | INOSITOL HEXAKISPHOSPHATE, Synaptotagmin-7 | Authors: | Zhang, Y, Zhang, X, Rao, F, Wang, C. | Deposit date: | 2019-11-20 | Release date: | 2021-03-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | 5-IP 7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis. Nat Metab, 3, 2021
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5HYN
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![BU of 5hyn by Molmil](/molmil-images/mine/5hyn) | Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide | Descriptor: | H3K27M, Histone-lysine N-methyltransferase EZH2, JARID2 K116me3, ... | Authors: | Zhang, Y, Justin, N, Wilson, J.R, Gamblin, S.J. | Deposit date: | 2016-02-01 | Release date: | 2016-05-11 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2. Nat Commun, 7, 2016
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5E17
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![BU of 5e17 by Molmil](/molmil-images/mine/5e17) | |
5E18
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![BU of 5e18 by Molmil](/molmil-images/mine/5e18) | |
4DC2
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![BU of 4dc2 by Molmil](/molmil-images/mine/4dc2) | Structure of PKC in Complex with a Substrate Peptide from Par-3 | Descriptor: | ADENINE, Partitioning defective 3 homolog, Protein kinase C iota type | Authors: | Shang, Y, Wang, C, Yu, J, Zhang, M. | Deposit date: | 2012-01-17 | Release date: | 2012-07-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKC iota in complex with a substrate peptide from Par-3 Structure, 20, 2012
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3MO0
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![BU of 3mo0 by Molmil](/molmil-images/mine/3mo0) | Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11 | Descriptor: | 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... | Authors: | Chang, Y, Horton, J.R, Cheng, X. | Deposit date: | 2010-04-22 | Release date: | 2010-06-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
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5D4E
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5JKJ
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![BU of 5jkj by Molmil](/molmil-images/mine/5jkj) | Crystal structure of esterase E22 L374D mutant | Descriptor: | Esterase E22 | Authors: | Zhang, Y, Wang, P, Yao, Q. | Deposit date: | 2016-04-26 | Release date: | 2017-04-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural basis for substrate recognition and catalysis of a novel esterase E22 with a homoserine transacetylase-like fold To Be Published
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5JKF
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![BU of 5jkf by Molmil](/molmil-images/mine/5jkf) | Crystal structure of esterase E22 | Descriptor: | Esterase E22 | Authors: | Zhang, Y, Wang, P, Yao, Q. | Deposit date: | 2016-04-26 | Release date: | 2017-04-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.393 Å) | Cite: | Structural basis for substrate recognition and catalysis of a novel esterase E22 with a homoserine transacetylase-like fold To Be Published
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3OMW
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![BU of 3omw by Molmil](/molmil-images/mine/3omw) | Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II | Descriptor: | CG14216 | Authors: | Zhang, Y, Zhang, M, Zhang, Y. | Deposit date: | 2010-08-27 | Release date: | 2011-01-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8701 Å) | Cite: | Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue. Biochem.J., 434, 2011
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3MO5
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![BU of 3mo5 by Molmil](/molmil-images/mine/3mo5) | Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 | Descriptor: | 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... | Authors: | Chang, Y, Horton, J.R, Cheng, X. | Deposit date: | 2010-04-22 | Release date: | 2010-06-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
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3MO2
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![BU of 3mo2 by Molmil](/molmil-images/mine/3mo2) | human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 | Descriptor: | 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... | Authors: | Chang, Y, Horton, J.R, Cheng, X. | Deposit date: | 2010-04-22 | Release date: | 2010-06-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
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3OMX
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![BU of 3omx by Molmil](/molmil-images/mine/3omx) | Crystal structure of Ssu72 with vanadate complex | Descriptor: | CG14216, VANADATE ION | Authors: | Zhang, Y, Zhang, M, Zhang, Y. | Deposit date: | 2010-08-27 | Release date: | 2011-01-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3366 Å) | Cite: | Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue. Biochem.J., 434, 2011
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3QXY
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![BU of 3qxy by Molmil](/molmil-images/mine/3qxy) | Human SETD6 in complex with RelA Lys310 | Descriptor: | 1,2-ETHANEDIOL, N-lysine methyltransferase SETD6, S-ADENOSYLMETHIONINE, ... | Authors: | Chang, Y, Levy, D, Horton, J.R, Peng, J, Zhang, X, Gozani, O, Cheng, X. | Deposit date: | 2011-03-02 | Release date: | 2011-05-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Nucleic Acids Res., 39, 2011
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3RC0
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![BU of 3rc0 by Molmil](/molmil-images/mine/3rc0) | Human SETD6 in complex with RelA Lys310 peptide | Descriptor: | 1,2-ETHANEDIOL, N-lysine methyltransferase SETD6, S-ADENOSYLMETHIONINE, ... | Authors: | Chang, Y, Levy, D, Horton, J.R, Peng, J, Zhang, X, Gozani, O, Cheng, X. | Deposit date: | 2011-03-30 | Release date: | 2011-05-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Nucleic Acids Res., 39, 2011
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2O3J
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![BU of 2o3j by Molmil](/molmil-images/mine/2o3j) | Structure of Caenorhabditis Elegans UDP-Glucose Dehydrogenase | Descriptor: | GLYCEROL, UDP-glucose 6-dehydrogenase | Authors: | Zhang, Y, Zhan, C, Patskovsky, Y, Ramagopal, U, Shi, W, Toro, R, Wengerter, B.C, Milst, S, Vidal, M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2006-12-01 | Release date: | 2006-12-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Crystal Structure of Caenorhabditis Elegans Udp-Glucose Dehydrogenase To be Published
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5BW0
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![BU of 5bw0 by Molmil](/molmil-images/mine/5bw0) | The crystal structure of minor pseudopilin binary complex of XcpV and XcpW from the Type 2 secretion system of Pseudomonas aeruginosa | Descriptor: | SULFATE ION, Type II secretion system protein I, Type II secretion system protein J | Authors: | Zhang, Y, Faucher, F, Poole, K, Jia, Z. | Deposit date: | 2015-06-05 | Release date: | 2016-07-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-guided disruption of the pseudopilus tip complex inhibits the Type II secretion in Pseudomonas aeruginosa. PLoS Pathog., 14, 2018
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6GFM
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![BU of 6gfm by Molmil](/molmil-images/mine/6gfm) | Crystal structure of the Escherichia coli nucleosidase PpnN (pppGpp-form) | Descriptor: | Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase, guanosine 5'-(tetrahydrogen triphosphate) 3'-(trihydrogen diphosphate) | Authors: | Zhang, Y, Baerentsen, R.L, Gerdes, K, Brodersen, D.E. | Deposit date: | 2018-05-01 | Release date: | 2019-04-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | (p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch. Mol.Cell, 74, 2019
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3UAT
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![BU of 3uat by Molmil](/molmil-images/mine/3uat) | |
6GFL
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![BU of 6gfl by Molmil](/molmil-images/mine/6gfl) | |
5D4D
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![BU of 5d4d by Molmil](/molmil-images/mine/5d4d) | |
5D4C
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![BU of 5d4c by Molmil](/molmil-images/mine/5d4c) | |
3QO2
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![BU of 3qo2 by Molmil](/molmil-images/mine/3qo2) | Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9 | Descriptor: | 1,2-ETHANEDIOL, Histone H3 peptide, M-phase phosphoprotein 8 | Authors: | Chang, Y, Horton, J.R, Bedford, M.T, Zhang, X, Cheng, X. | Deposit date: | 2011-02-09 | Release date: | 2011-04-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. J.Mol.Biol., 408, 2011
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