8FY5
 
 | | Human TMEM175-LAMP1 full-length complex | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | | Authors: | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | | Deposit date: | 2023-01-25 | | Release date: | 2023-06-28 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
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8FYF
 | | Human TMEM175-LAMP1 transmembrane domain only complex | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | | Authors: | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | | Deposit date: | 2023-01-26 | | Release date: | 2023-06-28 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
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7LGH
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7LGG
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7LGF
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7LGE
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7LHD
 | | The complete model of phage Qbeta virion | | Descriptor: | Capsid protein, Genomic RNA, Maturation protein A2 | | Authors: | Chang, J.Y, Zhang, J. | | Deposit date: | 2021-01-22 | | Release date: | 2022-01-26 | | Last modified: | 2022-03-09 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structural Assembly of Q beta Virion and Its Diverse Forms of Virus-like Particles.
Viruses, 14, 2022
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7XY7
 | | Adenosine receptor bound to a non-selective agonist in complex with a G protein obtained by cryo-EM | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. | | Deposit date: | 2022-05-31 | | Release date: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex.
Sci Adv, 8, 2022
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7XY6
 | | Adenosine receptor bound to an agonist in complex with G protein obtained by cryo-EM | | Descriptor: | 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. | | Deposit date: | 2022-05-31 | | Release date: | 2023-05-03 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex.
Sci Adv, 8, 2022
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3TC1
 | | Crystal Structure of Octaprenyl Pyrophosphate Synthase from Helicobacter pylori | | Descriptor: | MAGNESIUM ION, Octaprenyl Pyrophosphate Synthase | | Authors: | Zhang, J.Y, Zhang, X.L, Li, D.F, Zou, Q.M, Wang, D.C. | | Deposit date: | 2011-08-08 | | Release date: | 2011-08-31 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of Octaprenyl Pyrophosphate Synthase from Helicobacter pylori
To be Published
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7DGD
 | | apo state of class C GPCR | | Descriptor: | Metabotropic glutamate receptor 1 | | Authors: | Zhang, J.Y, Wu, L.J, Luo, F, Hua, T, Liu, Z.J. | | Deposit date: | 2020-11-11 | | Release date: | 2021-09-22 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Structural insights into the activation initiation of full-length mGlu1.
Protein Cell, 12, 2021
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7DGE
 | | intermediate state of class C GPCR | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 1, nanobody | | Authors: | Zhang, J.Y, Wu, L.J, Luo, F, Hua, T, Liu, Z.J. | | Deposit date: | 2020-11-11 | | Release date: | 2021-09-22 | | Method: | ELECTRON MICROSCOPY (3.65 Å) | | Cite: | Structural insights into the activation initiation of full-length mGlu1.
Protein Cell, 12, 2021
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5XS3
 | | Crystal structure of HLA Class I antigen | | Descriptor: | Heavy Chain, Light Chain, P | | Authors: | Wei, P.C, Yang, Y, Liu, Z.X, Luo, Z.Q, Tu, W.Y, Han, J.Y, Deng, Y.H, Yin, L. | | Deposit date: | 2017-06-12 | | Release date: | 2017-09-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Characterization of Autoantigen Presentation by HLA-C*06:02 in Psoriasis
J. Invest. Dermatol., 137, 2017
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8VM2
 | | Crystal Structure of NRAS Q61K bound to GTP | | Descriptor: | GTPase NRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Gebregiworgis, T, Chan, J.Y.L, Kuntz, D.A, Prive, G.G, Marshall, C.B, Ikura, M. | | Deposit date: | 2024-01-12 | | Release date: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.
Eur J Cell Biol, 103, 2024
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3AUV
 | | Predicting Amino Acid Preferences in the Complementarity Determining Regions of an Antibody-Antigen Recognition Interface | | Descriptor: | sc-dsFv derived from the G6-Fab | | Authors: | Yu, C.M, Peng, H.P, Chen, I.C, Lee, Y.C, Chen, J.B, Tsai, K.C, Chen, C.T, Chang, J.Y, Yang, E.W, Hsu, P.C, Jian, J.W, Hsu, H.J, Chang, H.J, Hsu, W.L, Huang, K.F, Ma, A.C, Yang, A.S. | | Deposit date: | 2011-02-16 | | Release date: | 2012-02-22 | | Last modified: | 2012-04-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface
Plos One, 7, 2012
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7Y3G
 | | Cryo-EM structure of a class A orphan GPCR | | Descriptor: | G-protein coupled receptor 12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Liu, Z.J, Hua, T, Li, H, Zhang, J.Y, Luo, F. | | Deposit date: | 2022-06-10 | | Release date: | 2023-06-07 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Structural insight into the constitutive activity of human orphan receptor GPR12.
Sci Bull (Beijing), 68, 2023
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8Q1N
 | | Cyclic peptide binder of the WBM-site of WDR5 | | Descriptor: | Cyclic peptide inhibitor, WD repeat-containing protein 5 | | Authors: | Schmeing, S, Chang, J.Y, t Hart, P, Gasper, R. | | Deposit date: | 2023-08-01 | | Release date: | 2023-09-06 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.843 Å) | | Cite: | Macrocyclic peptides as inhibitors of WDR5-lncRNA interactions.
Chem.Commun.(Camb.), 59, 2023
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7VXX
 | | Zika virus NS2B/NS3 protease bZipro(C143S) in complex with 4-amino benzamidine | | Descriptor: | P-AMINO BENZAMIDINE, Serine protease NS3, Serine protease subunit NS2B | | Authors: | Xiong, Y.C, Cheng, F, Zhang, J.Y, Su, H.X, Hu, H.C, Zou, Y, Li, M.J, Xu, Y.C. | | Deposit date: | 2021-11-13 | | Release date: | 2022-09-14 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease.
Bioorg.Chem., 128, 2022
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7VXY
 | | Zika virus NS2B/NS3 protease bZipro(C143S) in complex with D-RKOR | | Descriptor: | Peptide inhibitor, Serine protease NS3, Serine protease subunit NS2B | | Authors: | Xiong, Y.C, Cheng, F, Zhang, J.Y, Su, H.X, Hu, H.C, Zou, Y, Li, M.J, Xu, Y.C. | | Deposit date: | 2021-11-13 | | Release date: | 2022-09-14 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease.
Bioorg.Chem., 128, 2022
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