6D4B
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![BU of 6d4b by Molmil](/molmil-images/mine/6d4b) | Crystal structure of Candida boidinii formate dehydrogenase V123A mutant complexed with NAD+ and azide | Descriptor: | AZIDE ION, CHLORIDE ION, Formate dehydrogenase, ... | Authors: | Guo, Q, Ye, H, Gakhar, L, Cheatum, C.M, Kohen, A. | Deposit date: | 2018-04-17 | Release date: | 2019-04-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Oscillatory Active-site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase Acs Catalysis, 2019
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8TTT
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![BU of 8ttt by Molmil](/molmil-images/mine/8ttt) | Structure of SNX27 FERM complexed with Fam21A repeat 15 (1124-1140) | Descriptor: | DI(HYDROXYETHYL)ETHER, Fam21A repeat 15 peptide, GLYCEROL, ... | Authors: | Guo, Q, Chen, K.-E, Collins, B.M. | Deposit date: | 2023-08-15 | Release date: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TTU
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![BU of 8ttu by Molmil](/molmil-images/mine/8ttu) | Structure of SNX27 FERM complexed with Fam21A repeat 19 (1261 - 1274) | Descriptor: | DI(HYDROXYETHYL)ETHER, Fam21A repeat 19 peptide, GLYCEROL, ... | Authors: | Guo, Q, Chen, K.-E, Collins, B.M. | Deposit date: | 2023-08-15 | Release date: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TTV
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![BU of 8ttv by Molmil](/molmil-images/mine/8ttv) | |
2X6G
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![BU of 2x6g by Molmil](/molmil-images/mine/2x6g) | |
1GIU
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![BU of 1giu by Molmil](/molmil-images/mine/1giu) | A TRICHOSANTHIN(TCS) MUTANT(E85R) COMPLEX STRUCTURE WITH ADENINE | Descriptor: | ADENINE, RIBOSOME-INACTIVATING PROTEIN ALPHA-TRICHOSANTHIN | Authors: | Guo, Q, Liu, Y, Dong, Y, Rao, Z. | Deposit date: | 2001-03-15 | Release date: | 2003-06-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Substrate binding and catalysis in trichosanthin occur in different sites as revealed by the complex structures of several E85 mutants. Protein Eng., 16, 2003
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1GIS
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![BU of 1gis by Molmil](/molmil-images/mine/1gis) | A TRICHOSANTHIN(TCS) MUTANT(E85Q) COMPLEX STRUCTURE WITH 2'-DEOXY-ADENOSIN-5'-MONOPHOSPHATE | Descriptor: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, RIBOSOME-INACTIVATING PROTEIN ALPHA-TRICHOSANTHIN | Authors: | Guo, Q, Liu, Y, Dong, Y, Rao, Z. | Deposit date: | 2001-03-15 | Release date: | 2003-06-03 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Substrate binding and catalysis in trichosanthin occur in different sites as revealed by the complex structures of several E85 mutants. Protein Eng., 16, 2003
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2X6L
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![BU of 2x6l by Molmil](/molmil-images/mine/2x6l) | |
2X69
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![BU of 2x69 by Molmil](/molmil-images/mine/2x69) | |
6K0X
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1SK6
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![BU of 1sk6 by Molmil](/molmil-images/mine/1sk6) | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, Calmodulin, ... | Authors: | Guo, Q, Shen, Y, Zhukovskaya, N.L, Tang, W.J. | Deposit date: | 2004-03-04 | Release date: | 2004-06-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate. J.Biol.Chem., 279, 2004
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6EPF
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![BU of 6epf by Molmil](/molmil-images/mine/6epf) | Ground state 26S proteasome (GS1) | Descriptor: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ... | Authors: | Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R. | Deposit date: | 2017-10-11 | Release date: | 2018-02-07 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (11.8 Å) | Cite: | In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell, 172, 2018
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6EPE
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![BU of 6epe by Molmil](/molmil-images/mine/6epe) | Substrate processing state 26S proteasome (SPS2) | Descriptor: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ... | Authors: | Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R. | Deposit date: | 2017-10-11 | Release date: | 2018-02-07 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (12.8 Å) | Cite: | In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell, 172, 2018
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6EPD
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![BU of 6epd by Molmil](/molmil-images/mine/6epd) | Substrate processing state 26S proteasome (SPS1) | Descriptor: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ... | Authors: | Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R. | Deposit date: | 2017-10-11 | Release date: | 2018-02-07 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (15.4 Å) | Cite: | In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell, 172, 2018
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6EPC
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![BU of 6epc by Molmil](/molmil-images/mine/6epc) | Ground state 26S proteasome (GS2) | Descriptor: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 13, ... | Authors: | Guo, Q, Lehmer, C, Martinez-Sanchez, A, Rudack, T, Beck, F, Hartmann, H, Hipp, M.S, Hartl, F.U, Edbauer, D, Baumeister, W, Fernandez-Busnadiego, R. | Deposit date: | 2017-10-11 | Release date: | 2018-02-07 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (12.3 Å) | Cite: | In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell, 172, 2018
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6D4C
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![BU of 6d4c by Molmil](/molmil-images/mine/6d4c) | Crystal structure of Candida boidinii formate dehydrogenase V123G mutant complexed with NAD+ and azide | Descriptor: | AZIDE ION, CHLORIDE ION, Formate dehydrogenase, ... | Authors: | Guo, Q, Ye, H, Gakhar, L, Cheatum, C.M, Kohen, A. | Deposit date: | 2018-04-17 | Release date: | 2019-04-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Oscillatory Active-site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase Acs Catalysis, 2019
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6EZ8
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![BU of 6ez8 by Molmil](/molmil-images/mine/6ez8) | Human Huntingtin-HAP40 complex structure | Descriptor: | Factor VIII intron 22 protein, Huntingtin | Authors: | Guo, Q, Bin, H, Cheng, J, Pfeifer, G, Baumeister, W, Fernandez-Busnadiego, R, Kochanek, S. | Deposit date: | 2017-11-14 | Release date: | 2018-02-21 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | The cryo-electron microscopy structure of huntingtin. Nature, 555, 2018
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2WK3
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![BU of 2wk3 by Molmil](/molmil-images/mine/2wk3) | |
2COL
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![BU of 2col by Molmil](/molmil-images/mine/2col) | Crystal structure analysis of CyaA/C-Cam with Pyrophosphate | Descriptor: | Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin, ... | Authors: | Guo, Q, Tang, W.J, Shen, Y. | Deposit date: | 2005-05-18 | Release date: | 2006-01-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin Embo J., 24, 2005
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4DTT
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![BU of 4dtt by Molmil](/molmil-images/mine/4dtt) | Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367 | Descriptor: | 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, Insulin-degrading enzyme, ZINC ION | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | Deposit date: | 2012-02-21 | Release date: | 2013-02-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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1YRU
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1YRT
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![BU of 1yrt by Molmil](/molmil-images/mine/1yrt) | Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin | Descriptor: | Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin | Authors: | Guo, Q, Shen, Y, Lee, Y.S, Gibbs, C.S, Mrksich, M, Tang, W.J. | Deposit date: | 2005-02-04 | Release date: | 2006-01-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin. Embo J., 24, 2005
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4DWK
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![BU of 4dwk by Molmil](/molmil-images/mine/4dwk) | Structure of cystein free insulin degrading enzyme with compound bdm41671 ((s)-2-{2-[carboxymethyl-(3-phenyl-propyl)-amino]-acetylamino}-3-(1h-imidazol-4-yl)-propionic acid methyl ester) | Descriptor: | Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-L-histidinate | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | Deposit date: | 2012-02-24 | Release date: | 2013-04-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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1ZOT
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![BU of 1zot by Molmil](/molmil-images/mine/1zot) | crystal structure analysis of the CyaA/C-Cam with PMEAPP | Descriptor: | (ADENIN-9-YL-ETHOXYMETHYL)-HYDROXYPHOSPHINYL-DIPHOSPHATE, CALCIUM ION, Calmodulin, ... | Authors: | Guo, Q, Tang, W.J. | Deposit date: | 2005-05-13 | Release date: | 2005-08-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin. Embo J., 24, 2005
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3E50
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![BU of 3e50 by Molmil](/molmil-images/mine/3e50) | Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha | Descriptor: | Insulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION | Authors: | Guo, Q, Manolopoulou, M, Tang, W.-J. | Deposit date: | 2008-08-12 | Release date: | 2009-08-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395, 2010
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