6EPD

Substrate processing state 26S proteasome (SPS1)

Summary for 6EPD

EMDB information3914
DescriptorProteasome subunit alpha type-6, Proteasome subunit alpha type-2, Proteasome subunit alpha type-4, ... (32 entities in total)
Functional Keywordsups, substrate processing state, neuron degeneration, hydrolase
Biological sourceRattus norvegicus (Rat)
Total number of polymer chains32
Total molecular weight1284003.13
Authors
Guo, Q.,Lehmer, C.,Martinez-Sanchez, A.,Rudack, T.,Beck, F.,Hartmann, H.,Hipp, M.S.,Hartl, F.U.,Edbauer, D.,Baumeister, W.,Fernandez-Busnadiego, R. (deposition date: 2017-10-11, release date: 2018-02-07, Last modification date: 2019-12-11)
Primary citation
Guo, Q.,Lehmer, C.,Martinez-Sanchez, A.,Rudack, T.,Beck, F.,Hartmann, H.,Perez-Berlanga, M.,Frottin, F.,Hipp, M.S.,Hartl, F.U.,Edbauer, D.,Baumeister, W.,Fernandez-Busnadiego, R.
In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell, 172:696-705.e12, 2018
PubMed: 29398115 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2017.12.030
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
?

Structure validation

Ramachandran outliersSidechain outliers 2.9% 6.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload