6EZ8

Human Huntingtin-HAP40 complex structure

Summary for 6EZ8

• Entry DOI: 10.2210/pdb6ez8/pdb
• EMDB information: 3984
• Descriptor: Huntingtin, Factor VIII intron 22 protein (2 entities in total)
• Functional Keywords: huntingtin, hap40/f8a, cryo-em, huntington's disease, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 386617.25

Authors

Guo, Q.,Bin, H.,Cheng, J.,Pfeifer, G.,Baumeister, W.,Fernandez-Busnadiego, R.,Kochanek, S. (deposition date: 2017-11-14, release date: 2018-02-21, Last modification date: 2019-12-11)

• Primary citation: Guo, Q.,Cheng, J.,Seefelder, M.,Engler, T.,Pfeifer, G.,Oeckl, P.,Otto, M.,Moser, F.,Maurer, M.,Pautsch, A.,Baumeister, W.,Fernandez-Busnadiego, R.,Kochanek, S.; The cryo-electron microscopy structure of huntingtin.; Nature, 555:117-120, 2018; PubMed: 29466333; DOI: 10.1038/nature25502

Experimental method

ELECTRON MICROSCOPY (4 Å)