5L03
| Crystal structure of 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE Synthase from BURKHOLDERIA PSEUDOMALLEI bound to L-tryptophan hydroxamate | Descriptor: | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, N-hydroxy-L-tryptophanamide, ZINC ION | Authors: | Blain, J.M, Ghose, D, Gorman, J.L, Goshu, G.M, Ranieri, G, Zhao, L, Bode, B, Meganathan, R, Walter, R.L, Hagen, T.J, Horn, J.R. | Deposit date: | 2016-07-26 | Release date: | 2017-11-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.469 Å) | Cite: | Synthesis and Characterization of the Burkholderia pseudomallei IspF Inhibitor L-tryptophan hydroxamate To Be Published
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8G9X
| Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Changela, A, Gorman, J, Kwong, P.D. | Deposit date: | 2023-02-22 | Release date: | 2023-04-19 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4.46 Å) | Cite: | Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization. J.Virol., 97, 2023
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8G9W
| Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Changela, A, Gorman, J, Kwong, P.D. | Deposit date: | 2023-02-22 | Release date: | 2023-04-19 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4.66 Å) | Cite: | Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization. J.Virol., 97, 2023
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8G9Y
| Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 3) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Changela, A, Gorman, J, Kwong, P.D. | Deposit date: | 2023-02-22 | Release date: | 2023-04-19 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4.28 Å) | Cite: | Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization. J.Virol., 97, 2023
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7RJF
| MOPD-1 mutant-L47W | Descriptor: | MALONATE ION, ZINC ION, [L47W]MOPD-1 | Authors: | Huawu, Y, Conan, K.W, Gordon, J.K, Brett, M.C, Yen-Hua, H, David, J.C. | Deposit date: | 2021-07-20 | Release date: | 2021-10-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Rational Design of Potent Peptide Inhibitors of the PD-1:PD-L1 Interaction for Cancer Immunotherapy. J.Am.Chem.Soc., 143, 2021
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6OL3
| Crystal structure of an adenovirus virus-associated RNA | Descriptor: | Adenovirus Virus-Associated (VA) RNA I apical and central domains, POTASSIUM ION | Authors: | Hood, I.V, Gordon, J.M, Bou-Nader, C, Henderson, F.V, Bahmanjah, S, Zhang, J. | Deposit date: | 2019-04-15 | Release date: | 2019-07-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Crystal structure of an adenovirus virus-associated RNA. Nat Commun, 10, 2019
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7TXD
| Cryo-EM structure of BG505 SOSIP HIV-1 Env trimer in complex with CD4 receptor (D1D2) and broadly neutralizing darpin bnD.9 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Broadly neutralizing darpin bnd.9, ... | Authors: | Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L. | Deposit date: | 2022-02-08 | Release date: | 2023-04-12 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization. Nat.Struct.Mol.Biol., 30, 2023
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5F89
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1LIT
| HUMAN LITHOSTATHINE | Descriptor: | LITHOSTATHINE | Authors: | Bertrand, J.A, Pignol, D, Bernard, J.-P, Verdier, J.-M, Dagorn, J.-C, Fontacilla-Camps, J.C. | Deposit date: | 1996-01-17 | Release date: | 1997-01-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation. EMBO J., 15, 1996
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7S01
| X-ray structure of the phage AR9 non-virion RNA polymerase holoenzyme in complex with a forked oligonucleotide containing the P077 promoter | Descriptor: | DNA-directed RNA polymerase, DNA-directed RNA polymerase beta subunit, DNA-directed RNA polymerase beta' subunit, ... | Authors: | Leiman, P.G, Sokolova, M.L, Gordeeva, J, Fraser, A, Severinov, K.V. | Deposit date: | 2021-08-28 | Release date: | 2022-07-06 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase. Nat Commun, 13, 2022
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8VUE
| L5A7 Fab bound to Indonesia2005 Hemagglutinin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, ... | Authors: | Olia, A.S, Gorman, J, Kwong, P.D. | Deposit date: | 2024-01-29 | Release date: | 2024-05-22 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody. Front Immunol, 15, 2024
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1M6O
| Crystal Structure of HLA B*4402 in complex with HLA DPA*0201 peptide | Descriptor: | Beta-2-microglobulin, HLA DPA*0201 peptide, HLA class I histocompatibility antigen, ... | Authors: | Macdonald, W.A, Purcell, A.W, Williams, D.S, Mifsud, N.A, Ely, L.K, Gorman, J.J, Clements, C.S, Kjer-Nielsen, L, Koelle, D.M, Brooks, A.G, Lovrecz, G.O, Lu, L, Rossjohn, J, McCluskey, J. | Deposit date: | 2002-07-17 | Release date: | 2003-09-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition. J.Exp.Med., 198, 2003
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1N2R
| A natural selected dimorphism in HLA B*44 alters self, peptide reportoire and T cell recognition. | Descriptor: | ACETIC ACID, Beta-2-microglobulin, HLA DPA*0201 PEPTIDE, ... | Authors: | Macdonald, W.A, Purcell, A.W, Williams, D.S, Mifsud, N, Ely, L.K, Gorman, J.J, Clements, C.S, Kjer-Nielsen, L, Koelle, D.M, Brooks, A.G, Lovrecz, G.O, Lu, L, Rossjohn, J, McCluskey, J. | Deposit date: | 2002-10-24 | Release date: | 2004-03-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition. J.Exp.Med., 198, 2003
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2YMD
| Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with serotonin (5-hydroxytryptamine) | Descriptor: | GLYCEROL, PHOSPHATE ION, SEROTONIN, ... | Authors: | Kesters, D, Thompson, A.J, Brams, M, Elk, R.v, Spurny, R, Geitmann, M, Villalgordo, J.M, Guskov, A, Danielson, U.H, Lummis, S.C.R, Smit, A.B, Ulens, C. | Deposit date: | 2012-10-09 | Release date: | 2012-12-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structural Basis of Ligand Recognition in 5-Ht(3) Receptors. Embo Rep., 14, 2013
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1U59
| Crystal Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine | Descriptor: | STAUROSPORINE, Tyrosine-protein kinase ZAP-70 | Authors: | Jin, L, Pluskey, S, Petrella, E.C, Cantin, S.M, Gorga, J.C, Rynkiewicz, M.J, Pandey, P, Strickler, J.E, Babine, R.E, Weaver, D.T, Seidl, K.J. | Deposit date: | 2004-07-27 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine: IMPLICATIONS FOR THE DESIGN OF SELECTIVE INHIBITORS J.Biol.Chem., 279, 2004
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2YME
| Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with granisetron | Descriptor: | 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, ... | Authors: | Kesters, D, Thompson, A.J, Brams, M, Elk, R.v, Spurny, R, Geitmann, M, Villalgordo, J.M, Guskov, A, Danielson, U.H, Lummis, S.C.R, Smit, A.B, Ulens, C. | Deposit date: | 2012-10-09 | Release date: | 2012-12-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis of Ligand Recognition in 5-Ht3 Receptors. Embo Rep., 14, 2013
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7TZ0
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7TYZ
| Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DARPin FSR22, ... | Authors: | Kwon, Y.D, Gorman, J, Kwong, P.D. | Deposit date: | 2022-02-15 | Release date: | 2022-12-07 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19, 2023
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8DW2
| Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR22, and two antibody Fabs, S309 and CR3022 | Descriptor: | Antibody CR3022 heavy chain, Antibody CR3022 light chain, Antibody S309 heavy chain, ... | Authors: | Kwon, Y.D, Gorman, J, Kwong, P.D. | Deposit date: | 2022-07-30 | Release date: | 2022-12-07 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (4.11 Å) | Cite: | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19, 2023
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8DW3
| Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR16m, and two antibody Fabs, S309 and CR3022 | Descriptor: | Anti-SARS-CoV-2 DARPin SR16m, Antibody S309 light chain, Spike protein S1, ... | Authors: | Kwon, Y.D, Gorman, J, Kwong, P.D. | Deposit date: | 2022-07-30 | Release date: | 2022-12-07 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (4.26 Å) | Cite: | A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19, 2023
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1XX9
| Crystal Structure of the FXIa Catalytic Domain in Complex with EcotinM84R | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XI, Ecotin | Authors: | Jin, L, Pandey, P, Babine, R.E, Gorga, J.C, Seidl, K.J, Gelfand, E, Weaver, D.T, Abdel-Meguid, S.S, Strickler, J.E. | Deposit date: | 2004-11-04 | Release date: | 2004-11-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions J.Biol.Chem., 280, 2005
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1XXD
| Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin | Descriptor: | Coagulation factor XI, Ecotin | Authors: | Jin, L, Pandey, P, Babine, R.E, Gorga, J.C, Seidl, K.J, Gelfand, E, Weaver, D.T, Abdel-Meguid, S.S, Strickler, J.E. | Deposit date: | 2004-11-04 | Release date: | 2004-11-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions J.Biol.Chem., 280, 2005
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1XXF
| Crystal Structure of the FXIa Catalytic Domain in Complex with Ecotin Mutant (EcotinP) | Descriptor: | Coagulation factor XI, Ecotin, SODIUM ION | Authors: | Jin, L, Pandey, P, Babine, R.E, Gorga, J.C, Seidl, K.J, Gelfand, E, Weaver, D.T, Abdel-Meguid, S.S, Strickler, J.E. | Deposit date: | 2004-11-04 | Release date: | 2004-11-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions J.Biol.Chem., 280, 2005
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3CK9
| B. thetaiotaomicron SusD with maltoheptaose | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, SusD, ... | Authors: | Koropatkin, N.M, Martens, E.C, Gordon, J.I, Smith, T.J. | Deposit date: | 2008-03-14 | Release date: | 2008-05-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Starch catabolism by a prominent human gut symbiont is directed by the recognition of amylose helices. Structure, 16, 2008
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3CK7
| B. thetaiotaomicron SusD with alpha-cyclodextrin | Descriptor: | CALCIUM ION, Cyclohexakis-(1-4)-(alpha-D-glucopyranose), SusD | Authors: | Koropatkin, N.M, Martens, E.C, Gordon, J.I, Smith, T.J. | Deposit date: | 2008-03-14 | Release date: | 2008-04-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Starch catabolism by a prominent human gut symbiont is directed by the recognition of amylose helices. Structure, 16, 2008
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