8G9W

Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 1)

Summary for 8G9W

• Entry DOI: 10.2210/pdb8g9w/pdb
• EMDB information: 29880
• Descriptor: Envelope glycoprotein gp41, Envelope glycoprotein gp120, vFP49.02 heavy chain, ... (9 entities in total)
• Functional Keywords: hiv-1, fusion peptide, antibody, sosip, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 8
• Total formula weight: 286586.97

Authors

Changela, A.,Gorman, J.,Kwong, P.D. (deposition date: 2023-02-22, release date: 2023-04-19, Last modification date: 2023-06-14)

• Primary citation: Sastry, M.,Changela, A.,Gorman, J.,Xu, K.,Chuang, G.Y.,Shen, C.H.,Cheng, C.,Geng, H.,O'Dell, S.,Ou, L.,Rawi, R.,Reveiz, M.,Stewart-Jones, G.B.E.,Wang, S.,Zhang, B.,Zhou, T.,Biju, A.,Chambers, M.,Chen, X.,Corrigan, A.R.,Lin, B.C.,Louder, M.K.,McKee, K.,Nazzari, A.F.,Olia, A.S.,Parchment, D.K.,Sarfo, E.K.,Stephens, T.,Stuckey, J.,Tsybovsky, Y.,Verardi, R.,Wang, Y.,Zheng, C.Y.,Chen, Y.,Doria-Rose, N.A.,McDermott, A.B.,Mascola, J.R.,Kwong, P.D.; Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.; J.Virol., 97:e0160422-e0160422, 2023; PubMed: 37098956; DOI: 10.1128/jvi.01604-22

Experimental method

ELECTRON MICROSCOPY (4.66 Å)