4ONG
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![BU of 4ong by Molmil](/molmil-images/mine/4ong) | Fab fragment of 3D6 in complex with amyloid beta 1-40 | Descriptor: | 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein, ... | Authors: | Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S. | Deposit date: | 2014-01-28 | Release date: | 2014-06-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab. Alzheimers Res Ther, 6, 2014
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7PQ0
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![BU of 7pq0 by Molmil](/molmil-images/mine/7pq0) | Crystal structure of the Burkholderia Lethal Factor 1 (BLF1) C94S inactive mutant in complex with human eIF4A - Crystal form B | Descriptor: | Burkholderia Lethal Factor 1 (BLF1), Eukaryotic initiation factor 4A-I | Authors: | Mobbs, G.W, Aziz, A.A, Dix, S.R, Blackburn, G.M, Sedelnikova, S.E, Minshull, T.C, Dickman, M.J, Baker, P.J, Nathan, S, Firdaus-Raih, M, Rice, D.W. | Deposit date: | 2021-09-15 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1. Commun Biol, 5, 2022
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7PPZ
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![BU of 7ppz by Molmil](/molmil-images/mine/7ppz) | Crystal structure of the Burkholderia Lethal Factor 1 (BLF1) C94S inactive mutant in complex with human eIF4A - Crystal form A | Descriptor: | Burkholderia Lethal Factor 1 (BLF1), Eukaryotic initiation factor 4A-I | Authors: | Mobbs, G.W, Aziz, A.A, Dix, S.R, Blackburn, G.M, Sedelnikova, S.E, Minshull, T.C, Dickman, M.J, Baker, P.J, Nathan, S, Firdaus-Raih, M, Rice, D.W. | Deposit date: | 2021-09-15 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1. Commun Biol, 5, 2022
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8TER
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![BU of 8ter by Molmil](/molmil-images/mine/8ter) | Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber | Descriptor: | TRK-fused gene protein Low Complexity Domain P285L mutant | Authors: | Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S. | Deposit date: | 2023-07-06 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. Pnas Nexus, 2, 2023
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8TEQ
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![BU of 8teq by Molmil](/molmil-images/mine/8teq) | Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) G269V mutant, amyloid fiber | Descriptor: | TRK-fused gene protein Low Complexity Domain G269V mutant | Authors: | Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S. | Deposit date: | 2023-07-06 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. Pnas Nexus, 2, 2023
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8T8S
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![BU of 8t8s by Molmil](/molmil-images/mine/8t8s) | Sortilin-PGRN peptide complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Paragranulin peptide, ... | Authors: | Srivastava, D.B, Srivastava, A, Cherf, G.M, Low, L.Y, Kannan, G. | Deposit date: | 2023-06-23 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Structural studies of Sortilin-PGRN peptide complex To Be Published
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8T8R
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![BU of 8t8r by Molmil](/molmil-images/mine/8t8r) | Sortilin-PGRN peptide complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Paragranulin peptide, Sortilin, ... | Authors: | Srivastava, D.B, Srivastava, A, Cherf, G.M, Low, L.Y, Kannan, G. | Deposit date: | 2023-06-23 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Structural studies of Sortilin-PGRN peptide complex To Be Published
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7QRC
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![BU of 7qrc by Molmil](/molmil-images/mine/7qrc) | X-ray structure of Trypanosoma cruzi PEX14 in complex with a PEX5-PEX14 PPI inhibitor | Descriptor: | GLYCEROL, Peroxin-14, ~{N}-(5-ethyl-6-oxidanylidene-benzo[b][1,4]benzothiazepin-2-yl)-2-(4-fluorophenyl)ethanamide | Authors: | Napolitano, V, Popowicz, G.M, Dawidowski, M, Dubin, G. | Deposit date: | 2022-01-10 | Release date: | 2022-11-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma. Eur.J.Med.Chem., 243, 2022
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8VE0
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![BU of 8ve0 by Molmil](/molmil-images/mine/8ve0) | Human transthyretin covalently modified with A2-derived stilbene in the compressed conformation | Descriptor: | 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid, Transthyretin | Authors: | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | Deposit date: | 2023-12-18 | Release date: | 2024-01-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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7REX
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![BU of 7rex by Molmil](/molmil-images/mine/7rex) | |
8VE3
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![BU of 8ve3 by Molmil](/molmil-images/mine/8ve3) | Unliganded human transthyretin in the compressed conformation | Descriptor: | Transthyretin | Authors: | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | Deposit date: | 2023-12-18 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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7R94
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![BU of 7r94 by Molmil](/molmil-images/mine/7r94) | T-Plastin-F-actin complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Mei, L, Alushin, G.M. | Deposit date: | 2021-06-28 | Release date: | 2022-07-06 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural mechanism for bidirectional actin cross-linking by T-plastin. Proc.Natl.Acad.Sci.USA, 119, 2022
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8VE2
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![BU of 8ve2 by Molmil](/molmil-images/mine/8ve2) | Unliganded human transthyretin in the canonical conformation | Descriptor: | Transthyretin | Authors: | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | Deposit date: | 2023-12-18 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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8VE1
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![BU of 8ve1 by Molmil](/molmil-images/mine/8ve1) | Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation | Descriptor: | 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid, Transthyretin | Authors: | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | Deposit date: | 2023-12-18 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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8VE5
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![BU of 8ve5 by Molmil](/molmil-images/mine/8ve5) | (Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the compressed conformation | Descriptor: | 2-[(3,5-DICHLORO-4-TRIOXIDANYLPHENYL)AMINO]BENZOIC ACID, Transthyretin | Authors: | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | Deposit date: | 2023-12-18 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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8VE6
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![BU of 8ve6 by Molmil](/molmil-images/mine/8ve6) | (Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the frayed conformation | Descriptor: | 2-[(3,5-DICHLORO-4-TRIOXIDANYLPHENYL)AMINO]BENZOIC ACID, Transthyretin | Authors: | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | Deposit date: | 2023-12-18 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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8VE4
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![BU of 8ve4 by Molmil](/molmil-images/mine/8ve4) | Unliganded human transthyretin in the frayed conformation | Descriptor: | Transthyretin | Authors: | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | Deposit date: | 2023-12-18 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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4KGV
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![BU of 4kgv by Molmil](/molmil-images/mine/4kgv) | The R state structure of E. coli ATCase with ATP bound | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Aspartate carbamoyltransferase, Aspartate carbamoyltransferase regulatory chain, ... | Authors: | Cockrell, G.M, Zheng, Y, Guo, W, Peterson, A.W, Kantrowitz, E.R. | Deposit date: | 2013-04-29 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | New Paradigm for Allosteric Regulation of Escherichia coli Aspartate Transcarbamoylase. Biochemistry, 52, 2013
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4KAP
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![BU of 4kap by Molmil](/molmil-images/mine/4kap) | The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand | Descriptor: | 4,5,6,7-tetrafluoro-1,3-benzothiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION | Authors: | Lange, H, Lockett, M.R, Breiten, B, Heroux, A, Sherman, W, Rappoport, D, Yau, P.O, Snyder, P.W, Whitesides, G.M. | Deposit date: | 2013-04-22 | Release date: | 2013-07-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand. Angew.Chem.Int.Ed.Engl., 52, 2013
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4KGX
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![BU of 4kgx by Molmil](/molmil-images/mine/4kgx) | The R state structure of E. coli ATCase with CTP bound | Descriptor: | Aspartate carbamoyltransferase, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... | Authors: | Cockrell, G.M, Zheng, Y, Guo, W, Peterson, A.W, Kantrowitz, E.R. | Deposit date: | 2013-04-29 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | New Paradigm for Allosteric Regulation of Escherichia coli Aspartate Transcarbamoylase. Biochemistry, 52, 2013
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6EBO
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![BU of 6ebo by Molmil](/molmil-images/mine/6ebo) | Crystal Structure of the Class Ie Ribonucleotide Reductase Beta Subunit from Aerococcus urinae in Unactivated Form | Descriptor: | CALCIUM ION, GLYCEROL, Ribonucleoside-diphosphate reductase, ... | Authors: | Palowitch, G.M, Alapati, R.B, Boal, A.K. | Deposit date: | 2018-08-06 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6EBQ
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![BU of 6ebq by Molmil](/molmil-images/mine/6ebq) | |
6E7B
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![BU of 6e7b by Molmil](/molmil-images/mine/6e7b) | 13-pf 3-start GMPCPP-human alpha1B/beta3 microtubules | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | Authors: | Ti, S.C, Alushin, G.M, Kapoor, T.M. | Deposit date: | 2018-07-25 | Release date: | 2018-10-10 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Human beta-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability. Dev. Cell, 47, 2018
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6E7C
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![BU of 6e7c by Molmil](/molmil-images/mine/6e7c) | 14-pf 3-start GMPCPP-human alpha1B/beta2B microtubules | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | Authors: | Ti, S.C, Alushin, G.M, Kapoor, T.M. | Deposit date: | 2018-07-25 | Release date: | 2018-10-10 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Human beta-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability. Dev. Cell, 47, 2018
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6EBZ
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![BU of 6ebz by Molmil](/molmil-images/mine/6ebz) | |