8VE1

Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation

Summary for 8VE1

• Entry DOI: 10.2210/pdb8ve1/pdb
• EMDB information: 43161
• Descriptor: Transthyretin, 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (3 entities in total)
• Functional Keywords: amyloidosis, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 56256.98

Authors

Basanta, B.,Nugroho, K.,Yan, N.,Kline, G.M.,Tsai, F.J.,Wu, M.,Kelly, J.W.,Lander, G.C. (deposition date: 2023-12-18, release date: 2024-06-05)

• Primary citation: Basanta, B.,Nugroho, K.,Yan, N.,Kline, G.M.,Powers, E.T.,Tsai, F.J.,Wu, M.,Hansel-Harris, A.,Chen, J.,Forli, S.,Kelly, J.W.,Lander, G.C.; The conformational landscape of human transthyretin revealed by cryo-EM; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.7 Å)