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8VE1

Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation

Summary for 8VE1
Entry DOI10.2210/pdb8ve1/pdb
EMDB information43161
DescriptorTransthyretin, 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (3 entities in total)
Functional Keywordsamyloidosis, transport protein
Biological sourceHomo sapiens (human)
Total number of polymer chains4
Total formula weight56256.98
Authors
Basanta, B.,Nugroho, K.,Yan, N.,Kline, G.M.,Tsai, F.J.,Wu, M.,Kelly, J.W.,Lander, G.C. (deposition date: 2023-12-18, release date: 2024-06-05, Last modification date: 2024-10-16)
Primary citationBasanta, B.,Nugroho, K.,Yan, N.,Kline, G.M.,Powers, E.T.,Tsai, F.J.,Wu, M.,Hansel-Harris, A.,Chen, J.,Forli, S.,Kelly, J.W.,Lander, G.C.
The conformational landscape of human transthyretin revealed by cryo-EM
To Be Published,
Experimental method
ELECTRON MICROSCOPY (2.7 Å)
Structure validation

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PDB entries from 2024-11-13

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